Hyperbolic relation between beta-cell function and insulin sensitivity for type 2 diabetes mellitus, malaria, influenza, Helicobacter pylori, Chlamydia pneumoniae,and hepatitis C virus infection-induced inflammation/oxidative stress and temporary insulin resistance in Central Africans*

On'kin, J.B. Kasiam Lasi; Longo-Mbenza, Benjamin; Tchokonte-Nana, Venant; Okwe, A. Nge; Kabangu, N. Kangola

doi:10.3906/sag-1608-48

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…Central African [49], African-American [50], European American [51], Caucasian [36] and Asian [52,53] studies. Our results concurred, however, with data obtained in populations other than Black sub-Saharan…”

Section: Discussionmentioning

confidence: 99%

Association between insulin resistance and left ventricular hypertrophy in asymptomatic Black sub-Saharan African hypertensive patients: A case-control study

Phanzu

Aliocha

Eleuthère

et al. 2020

Preprint

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Background: Conflicting information exists regarding the association between insulin resistance (IR) and left ventricular hypertrophy (LVH). Here, we described the associations between parameters of obesity, fasting insulinaemia, homeostasis model assessment of insulin resistance (HOMA-IR) and LVH in Black patients with essential hypertension. Methods: A case-control study was conducted at the Centre Médical de Kinshasa (CMK), the Democratic Republic of the Congo, between January and December 2019. Cases and controls were hypertensive patients with and without LVH, respectively. The relationships between obesity indices, physical inactivity, parameters of glucose metabolism and lipid disorders and LVH were assessed using linear and logistic regression analyses in simple and univariate exploratory analyses, respectively. When differences were observed between LVH and the independent variables, the effect of potential confounders was studied by adjustment in multiple linear regression and conditional logistic regression in multivariate analysis. The coefficients of determination (R2), the adjusted ORs and their 95% CIs were calculated to determine the association between LVH and the independent variables. Results: Eighty-eight cases (52 men) were compared to 132 controls (81 men). Nineteen percent (19%) of left ventricular mass (LVM) variation was predicted by age; 31.3%, by the duration of hypertension; 44.4%, by body mass index (BMI); 42.5%, by waist circumference (WC); 20%, by glycaemia; 44.8%, by insulinaemia; and 43.7%, by HOMA-IR. In multiple linear regression analysis, duration of hypertension, BMI, insulinaemia and HOMA-IR explained 68.3% of the variability in the increase in LVM. In the logistic model, obesity multiplied the risk of LVH by 3 (aOR: 2.8, 95% CI (1.06-7.4), p = 0.038) and IR by 8 (aOR: 8.4, 95: (3.7-15.7), p <0.001). Conclusions: Obesity and IR appear to be the main predictors of LVH in Black sub-Saharan African hypertensive patients. The comprehensive management of cardiovascular risk factors should be emphasized with particular attention to obesity and IR. A prospective Black sub-Saharan population-based study with serial imaging remains essential to better understand subclinical LV deterioration over time and to confirm the role of IR in Black sub-Saharan individuals with hypertension.

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Section: Discussionmentioning

confidence: 99%

Association between insulin resistance and left ventricular hypertrophy in asymptomatic Black sub-Saharan African hypertensive patients: A case-control study

Phanzu

Aliocha

Eleuthère

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…No established agreed HOMA-IR threshold for de ning IR in the sub-Saharan Black African population. The cut-off of 2.5, which was used in the present study, has previously been used in Black Central African [49], African-American [50], European American [51], Caucasian [36], and Asian [52,53] studies. However, our results agree with data obtained in populations other than Black sub-Saharan Africans.…”

Section: Discussionmentioning

confidence: 99%

Association between insulin resistance and left ventricular hypertrophy in asymptomatic Black sub-Saharan African hypertensive patients: A case-control study

Phanzu

Aliocha

Eleuthère

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Conflicting information exists regarding the association between insulin resistance (IR) and left ventricular hypertrophy (LVH).We described the associations between obesity, fasting insulinemia, homeostasis model assessment of insulin resistance (HOMA-IR), and LVH in Black patients with essential hypertension.Methods: A case-control study was conducted at the Centre Médical de Kinshasa (CMK), the Democratic Republic of the Congo, between January and December 2019. Cases and controls were hypertensive patients with and without LVH, respectively. The relationships between obesity indices, physical inactivity, glucose metabolism and lipid disorder parameters, and LVH were assessed using linear and logistic regression analyses in simple and univariate exploratory analyses, respectively. When differences were observed between LVH and independent variables, the effects of potential confounders were studied through the use of multiple linear regression and in conditional logistic regression in multivariate analyses. The coefficients of determination (R2), adjusted odds ratios (aORs), and their 95% confidence intervals (95% CIs) were calculated to determine associations between LVH and the independent variables.Results: Eighty-eight LVH cases (52 men) were compared against 132 controls (81 men). Variation in left ventricular mass (LVM) could be predicted by the following variables: age (19%), duration of hypertension (31.3%), body mass index (BMI, 44.4%), waist circumference (WC, 42.5%), glycemia (20%), insulinemia (44.8%), and HOMA-IR (43.7%). Hypertension duration, BMI, insulinemia, and HOMA-IR explained 68.3% of LVM variability in the multiple linear regression analysis. In the logistic regression model, obesity increased the risk of LVH by 3-fold [aOR: 2.8; 95% CI (1.06–7.4); p = 0.038], and IR increased the risk of LVH by 8-fold [aOR: 8.4; 95: (3.7–15.7); p < 0.001].Conclusion: Obesity and IR appear to be the primary predictors of LVH in Black sub-Saharan African hypertensive patients. The comprehensive management of cardiovascular risk factors should be emphasized, with particular attention paid to obesity and IR. A prospective population-based study of Black sub-Saharan individuals that includes the use of serial imaging remains essential to better understand subclinical LV deterioration over time and to confirm the role played by IR in Black sub-Saharan individuals with hypertension.

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“…No standard HOMA-IR threshold has been established to define IR in the population of Sub-Saharan Black with hypertension. The threshold of 2.5 used in this study has been used in various studies conducted in African [22], African American [10], Euro-American [23], Caucasian [24], and Asian populations [25,26].…”

Section: Discussionmentioning

confidence: 99%

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2019

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Cross-sectional analysis was performed on data from 105 asymptomatic non diabetic participants with hypertension (56 men, 53.3%) aged 57 ± 11 years. The participants were consecutively selected during outpatient consultations from January 5, 2012, to January 5, 2013, in Lomo Medical Clinic, a private hospital center in Limete, Kinshasa, Democratic Republic of Congo.The inclusion criteria were age of 20 years and above; absence of previous cardiovascular history, including stroke, acute coronary

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Hyperbolic relation between beta-cell function and insulin sensitivity for type 2 diabetes mellitus, malaria, influenza, Helicobacter pylori, Chlamydia pneumoniae,and hepatitis C virus infection-induced inflammation/oxidative stress and temporary insulin resistance in Central Africans*

Cited by 11 publications

References 28 publications

Association between insulin resistance and left ventricular hypertrophy in asymptomatic Black sub-Saharan African hypertensive patients: A case-control study

Association between insulin resistance and left ventricular hypertrophy in asymptomatic Black sub-Saharan African hypertensive patients: A case-control study

Association between insulin resistance and left ventricular hypertrophy in asymptomatic Black sub-Saharan African hypertensive patients: A case-control study

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