Hyperbranched poly (ester) s for delivery of small molecule therapeutics

Zhang, Tracy; Howell, Bob A.; Zhang, Dongke; Zhu, Brandon; Smith, Patrick B.

doi:10.1002/pat.4347

Cited by 10 publications

(13 citation statements)

References 59 publications

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“…Besides linear PGAd, hyperbranched PGAd was recently used as a matrix for the sustained release of 2-undecanone and salicylic acid, which were covalently bonded to the hydroxyl end groups of PGAd [70]. The release of both molecules took place by chemical or enzymatic hydrolysis while their release rate depended on the composite structure and the amount of catalyst used.…”

Section: Pgad Conjugatesmentioning

confidence: 99%

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Zamboulis

Nakiou

Christodoulou

et al. 2019

IJMS

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In a century when environmental pollution is a major issue, polymers issued from bio-based monomers have gained important interest, as they are expected to be environment-friendly, and biocompatible, with non-toxic degradation products. In parallel, hyperbranched polymers have emerged as an easily accessible alternative to dendrimers with numerous potential applications. Glycerol (Gly) is a natural, low-cost, trifunctional monomer, with a production expected to grow significantly, and thus an excellent candidate for the synthesis of hyperbranched polyesters for pharmaceutical and biomedical applications. In the present article, we review the synthesis, properties, and applications of glycerol polyesters of aliphatic dicarboxylic acids (from succinic to sebacic acids) as well as the copolymers of glycerol or hyperbranched polyglycerol with poly(lactic acid) and poly(ε-caprolactone). Emphasis was given to summarize the synthetic procedures (monomer molar ratio, used catalysts, temperatures, etc.,) and their effect on the molecular weight, solubility, and thermal and mechanical properties of the prepared hyperbranched polymers. Their applications in pharmaceutical technology as drug carries and in biomedical applications focusing on regenerative medicine are highlighted.

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Section: Pgad Conjugatesmentioning

confidence: 99%

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Zamboulis

Nakiou

Christodoulou

et al. 2019

IJMS

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“…2 Consequently, they have many virtues such as low price, lightweight, heat insulation, and high impact resistance. 3 These superior properties made them appropriate for a versatile of applications, including acoustic absorption, thermal insulation, impact resistance, and scaffolds for tissue engineering. 4,5 In general, common preparation methods of microcellular polymer foams included physical foaming method and chemical foaming method.…”

Section: Introductionmentioning

confidence: 99%

“…11 Up to now, a large number of literatures about microcellular polymer foaming technology have been reported, including microcellular polypropylene, polyethylene (PE), and polystyrene (PS) foams. 1,3,12 Among them, microcellular PE and PS foams were used most widely in the world, but their low heat distortion temperature and no degradability were harmful to their applications in many fields. For example, microcellular PE and PS foams Additional Supporting Information may be found in the online version of this article.…”

Section: Introductionmentioning

confidence: 99%

Simple and feasible strategy to fabricate microcellular poly(butylene succinate) foams by chain extension and isothermal crystallization induction

Yin

Zhou

et al. 2019

J of Applied Polymer Sci

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In this article, a facile and efficient isothermal crystallization induction method was proposed to fabricate microcellular poly(butylene succinate) (PBS) foams with supercritical CO2. The good regularity of PE chain segments and high reactive epoxy groups in ethylene‐glycidyl methacrylate copolymer (PE‐g‐GMA) serving as a chain extender were employed to improve the crystallization behaviors, viscoelasticity, and foaming behaviors of PBS through chain extension reaction. The effect of PE‐g‐GMA content on the thermal properties, rheological performances, and cellular morphology of various PBS samples was investigated systematically. When the PE‐g‐GMA content switched from 7.5 to 10 wt %, an interesting transition from fine cells to microcells was observed in PBS/PE‐g‐GMA foams. Microcellular PBS foam modified by 10 wt % PE‐g‐GMA was successfully prepared at the foaming temperature of 87 °C and the induction time of 7 min, in which its cell size and cell density could reach 6.63 ± 1.93 μm and 3.75 × 109 cells cm−3, respectively. The formation of abundant but tiny spherocrystals in chain extended PBS samples made a considerable contribution for preparing microcellular PBS foams. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48850.

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“…By reacting an AB monomer with a CD n monomer via Michael addition, he generated AD n ‐type intermediates that through self‐condensation yielded a hyperbranched polyester . Dr. Smith used a trifunctional bio‐alcohol and a difunctional bio‐acid (A 2 +B 3 system) to generate a biodegradable HBPE for the controlled time release of small molecule therapeutics . Also utilizing an A 2 +B 3 system, Dr. Bruchmann obtained a HBPE via a one‐step polycondensation, generating polymers with a high degree of functionality and high molecular weights .…”

Section: Introductionmentioning

confidence: 99%

“…[19] Dr. Smith used a trifunctional bio-alcohol and a difunctional bio-acid (A 2 + B 3 system) to generate a biodegradable HBPE for the controlled time release of small molecule therapeutics. [22] Also utilizing an A 2 + B 3 system, Dr. Bruchmann obtained a HBPE via a one-step polycondensation, generating polymers with a high degree of functionality and high molecular weights. [23] This biodegradable polymer would be an ideal material for use in drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Hyperstar Polyester‐Based Functional Nanotheranostics for the Targeted Drug Delivery and Treatment of Cancer

2019

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In this study, we have synthesized new class of hyperstar polyester (HSPE) polymer using a functional A2B monomer and bio‐based sorbitol. We hypothesize that by incorporating sorbitol, its amphiphilic nature will give the polymer greater solubility and allow for the encapsulation of wide range of anti‐cancer therapeutics. We used potassium methoxide to catalyze the melt polymerization reaction. Using the solvent diffusion method, this polymer was used to construct polymeric nanoparticles to encapsulate therapeutics, in one step, for monitoring drug delivery and treatment. The cytotoxicity of our HSPE nanoparticles was evaluated by a cell‐based MTT assays using prostate cancer cells (LNCaP) and healthy cells (CHO). In addition, the level of internalization of our HSPE nanoparticles was evaluated using fluorescence microscopy. Results showed the HSPE nanoparticles have the capability to target and concurrently image and kill cancer cells. Taken together, these studies indicate the successful development of a new drug delivery system and demonstrated its potential use in the pharmaceutical industry and the field of medicine.

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Hyperbranched poly (ester) s for delivery of small molecule therapeutics

Cited by 10 publications

References 59 publications

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Simple and feasible strategy to fabricate microcellular poly(butylene succinate) foams by chain extension and isothermal crystallization induction

Hyperstar Polyester‐Based Functional Nanotheranostics for the Targeted Drug Delivery and Treatment of Cancer

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