Hyperbranched polyester polyacids and their binary systems with surfactants for doxorubicin encapsulation

Khannanov, Artur; Кутырева, М. П.; Улахович, Н. А.; Гатаулина, А. Р.; Bondar, O. V.; Zakharova, L. Ya.; Кутырев, Г. А.

doi:10.1016/j.fluid.2015.12.023

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…It has been shown that the polymer content in the system [BH20-COOH/TX-100] increases by 5 times due to the solubilization effect when surfactants are used. From the results of this study and the data obtained earlier, 42 it may be noted that the content of the hyperbranched carboxylterminated polyester in surfactant-organized hybrid micelles depends on the generation (G) polymer.…”

Section: ■ Conclusionsupporting

confidence: 71%

“…Terminal functionalization of the hyperbranched polyester polyol with monoester fragments of maleic acid allows one to obtain the hyperbranched polymer BH20 -COOH with hydrophilic properties and the ability to self-associate in aqueous solutions. , Description of the synthesis of the hyperbranched polyester polyol with the terminal carboxyl group BH20- COOH is presented in the Supporting Information (Figures S1–S3). The functionalization efficiency (%) of the binding of maleic acid with BH2O was evaluated according to the method presented in article and amounted to 34.7 ± 0.4%.…”

Section: Results and Discussionmentioning

confidence: 99%

“…A second-generation hyperbranched polyester polyol with terminal carboxylic group BH20 -COOH was prepared by the esterification of hyperbranched polyester polyol Boltorn H20 (16 hydroxyl groups, M r = 1749.79 g × mol –1 , hydroxyl number 490–520 mg(KOH) × g –1 , Perstorp Chemicals AB, CAS No. : 326794-48-3) with maleic anhydride (99%, Alfa Asear) in 1,4-dioxane by the procedure. − The compositions of the BH20- COOH were confirmed by Fourier transform infrared (FT-IR) and 1 H and 13 CH nuclear magnetic resonance (NMR) spectroscopy. Proof of the structure and spectral parameters are presented in the Supporting Information (Figures S1–S3).…”

Section: Methodsmentioning

confidence: 99%

“…Proof of the structure and spectral parameters are presented in the Supporting Information (Figures S1–S3). − BH20 -COOH : Yield 4.08 Γ (61%), acid number 49.3 ± 0.2 mg KOH × g –1 , concentration of acid groups 0.84 mM × g –1 .…”

Section: Methodsmentioning

confidence: 99%

“…Before the study, the HM solution was filtered through a 0.45 μm filter. The degree of encapsulation of doxorubicin was evaluated using a calibration graph and association calculations were performed similarly to ref .…”

Section: Methodsmentioning

confidence: 99%

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Doxorubicin-Loaded Hybrid Micelles Based on Carboxyl-Terminated Hyperbranched Polyester Polyol

Khannanov

Rossova

Улахович

et al. 2022

ACS Appl. Polym. Mater.

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The study of self-assembly processes in polymer solutions is the basis of a modern strategy for creating targeting systems for various substrates. In turn, the use of binary polymer/surfactant systems makes it possible to expand the range of polymers for creating drug delivery systems. This article describes the processes of formation of hybrid micelles based on carboxylterminal hyperbranched polyester polyol Boltorn H20[BH20-COOH] and surfactant Triton X-100[BH20-COOH/TX-100]. Using pH-metry, conductometry, dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), and scanning electron microscopy (SEM), it was shown that at pH = 6.5, a monodisperse [BH20-COOH] associate with a hydrodynamic diameter D h = 79 ± 10 nm and hybrid micelles [BH20-COOH/TX-100] with D h = 114.3 ± 6 nm are formed. Both types of supramolecular associates are able to effectively encapsulate the anticancer drug doxorubicin. The viability analysis of HeLa and MCF-7 cells was performed in the presence of doxorubicin-loaded [BH20-COOH] and hybrid micelles [BH20-COOH/TX-100] in vitro.

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Section: ■ Conclusionsupporting

confidence: 71%