Hypercalcemia and nephrocalcinosis in patients with congenital lactase deficiency

Nephrocalcinosis in full-term infants receiving furosemide treatment for congestive heart failure: a study of the incidence and 2-year follow up

“…A CT scan, however, which would have been more de®nitive to assure the calcium content of a hyperechogenic ®nding, was not performed on the present infants. No signs of the cluster of diseases with which nephrocalcinosis has also been reported, such as X-linked hypophosphataemic rickets, polycystic kidney disease, congenital lactase de®ciency or other metabolic abnormalities [2,12,15], were observed in these infants. The incidence of nephrocalcinosis observed in our full-term infants treated with furosemide is clearly below the ®gures of 34% to 93% reported in furosemide-treated very low birth weight infants [1].…”

Two Cases of Mistaken Polyuria and Nephrocalcinosis in Infants with Glucose-Galactose Malabsorption: A Possible Role of 1,25(OH)₂D₃

“…Other primary intestinal malabsorption syndromes such as sucrase-isomaltase deficiency and congenital lactase deficiency have reported similar associations [22, 23]. Dehydration and chronic metabolic acidosis secondary to stool bicarbonate loss have been suggested as possible mechanisms [23].…”

“…Other primary intestinal malabsorption syndromes such as sucrase-isomaltase deficiency and congenital lactase deficiency have reported similar associations [22, 23]. Dehydration and chronic metabolic acidosis secondary to stool bicarbonate loss have been suggested as possible mechanisms [23]. In metabolic acidosis, buffering of bone salts is believed to raise serum calcium and reduce urinary citrate promoting crystallization, all of which can be exacerbated by oliguria [6, 23].…”

“…Dehydration and chronic metabolic acidosis secondary to stool bicarbonate loss have been suggested as possible mechanisms [23]. In metabolic acidosis, buffering of bone salts is believed to raise serum calcium and reduce urinary citrate promoting crystallization, all of which can be exacerbated by oliguria [6, 23]. Some reports of subjects with GGM have mentioned a persistence of hypercalcemia [4], while others reported a progression of nephrocalcinosis to nephrolithiasis with normal serum calcium levels [5, 10].…”

Nephrocalcinosis in glucose-galactose malabsorption: nephrocalcinosis and proximal tubular dysfunction in a young infant with a novel mutation of SGLT1

“…Some authors have attributed this hypercalcaemia partly to increased intestinal absorption of calcium due to accumulation of glucose and galactose [6]. Similarly, hypercalcaemia is common in congenital lactase deficiency, possibly due to non-absorbed lactose having a direct effect on calcium absorption [7]. A similar mechanism was proposed to occur in congenital sucrase-isomaltase deficiency [3].…”