Hypercholesterolemic Effect in the Female Rat of Egg Yolk Versus Crystalline Cholesterol Dissolved in Lard

Bartov, I.; Reiser, Raymond; Henderson, Glen R.

doi:10.1093/jn/103.10.1400

Cited by 15 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the major portion of the longer chain n-3 PUFA (EPA, DPA, and DHA) in the n-3 yolks ~esided in phospholipid classes, particularly in phosphatidylethanolamine (30). The plasma cholesterol of female rats was more responsive to dietary manipulation than that of male ones (33,34). The enrichment of yolk phospholipids with EPA, DPA, and DHA might thus enhance the ability of lipid modification by n-3 PUFA-enriched yolks.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary n−3 fatty acid‐enriched chicken eggs on plasma and tissue cholesterol and fatty acid composition of rats

Jiang

Sim

1992

Lipids

View full text Add to dashboard Cite

The purpose of this study was to examine the effects of feeding n-3 polyunsaturated fatty acid (PUFA)-enriched chicken eggs on plasma and liver cholesterol levels and fatty acid composition in rats. Eggs were collected from laying hens fed diets containing 10% flax seed (Hn-3), 12% sunflower seed (Hn-6), or wheat and soybean meal control (CON). Yolk powders were prepared and fed at the 15% level to weanling female Sprague-Dawley rats for 28 days. Consumption of n-3 PUFA-enriched yolks significantly reduced both plasma and liver total cholesterol. Liver total lipids and phospholipids of rats fed Hn-3 diet were enriched with linolenic, eicosapentaenoic, and docosahexaenoic acids with a concomitant reduction of arachidonic acid in liver phospholipids. The plasma cholesterol of rats fed yolk powders enriched with n-6 PUFA (mainly linoleic acid) was reduced to the same extent as in those fed the n-3 enriched, but the liver cholesterol was significantly increased, indicating differential effects of dietary n-3 and n-6 PUFA. The results demonstrated that the cholesterolemic and tissue lipid modulating properties of chicken eggs could be modified in a favorable way by altering the fatty acid composition of yolk lipids through manipulation of laying hen diets.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of dietary n−3 fatty acid‐enriched chicken eggs on plasma and tissue cholesterol and fatty acid composition of rats

Jiang

Sim

1992

Lipids

View full text Add to dashboard Cite

show abstract

“…However, the concomitant differences in serum cholesterol levels cannot be due to a limited capacity of the females to excrete bile acids, a phenomenon in squirrel monkeys which has been attributed to genotype differences (11). The results of the pres ent study and of previous ones with rats (4) and cockerels (3) show that increased blood cholesterol levels of those animals when fed cholesterol (3 ,4 ) or even on commercial diet low in cholesterol (3) are always followed by increased excretion of bile acids. On the other hand, the relationship between blood cholesterol levels and fecal bile acid excretion in human beings fed fats with different fatty acid composition are quite different.…”

Section: Discussionmentioning

confidence: 60%

Sex Differences in Steroid Retention and Excretion in Rats Fed Cholesterol

Bartov¹,

Henderson²,

Reiser³

1974

Ann Nutr Metab

Self Cite

View full text Add to dashboard Cite

The mechanism by which female rats maintain a higher level of serum cholesterol than males on cholesterol containing diets was studied. Retention of neutral steroids and excretion of bile acids were significantly higher in females than in males. The composition of fecal bile acids was also sex-dependent. Lithocholic and α-muricholic acids were predominant in females and hyodeoxycholic in males. It was concluded that the sex differences in blood cholesterol levels are mainly due to the higher retention rate of neutral steroids by the females and not by their limited capacity to excrete bile acids.

show abstract

“…Tingginya kenaikan kadar kolesterol karena kuning telur yang diberikan mengandung tinggi kolesterol dan asam lemak jenuh. 10 Aterosklerosis dapat timbul dengan mudah pada hewan yang diberi diet tinggi kolesterol. Oleh karena itu, komponen utama plak aterosklerosis adalah kolesterol.…”

Section: Pembahasanunclassified

Pencegahan Lesi Aterosklerosis Oleh Asam Alfa Lipoat Pada Aorta Mencit Jantan (Mus Musculus) Yang Diberi Diet Tinggi Kolesterol

Ismawati¹,

Winarto²,

Sari³

2017

JIK

View full text Add to dashboard Cite

Atherosclerosis can happen easily on animal that are given high cholesterol diet. Alpha lipoic acid is universal antioxidant that very effective to reduce free radicals, include lipid peroxide. The goal of this research was to find out the prohibition of atherosclerosis lesion development on male mice aorta that was given high cholesterol diet by alpha lipoic acid. This was an experimental laboratory research with post test only design. Eighteen adult male mice were segregated into three groups labelled as group NaCl 0,9%, yolks and ALA.. The experiment was design for 6 weeks. The measured parameter was atherosclerosis lesion score of groups labelled. The statistical test result showed the significant difference of some tested groups. There was a statistically significant difference between alpha lipoic acid and yolks group (p=0,008), but there is no significant difference was found between ALA and NaCl 0,9% group (p=0,126). As the conclusion, this study proves that alpha lipoic acid has the effects to prohibition of atherosclerosis lesion development on male mice aorta that are given high cholesterol diet.

show abstract

Hypercholesterolemic Effect in the Female Rat of Egg Yolk Versus Crystalline Cholesterol Dissolved in Lard

Cited by 15 publications

References 21 publications

Effects of dietary n−3 fatty acid‐enriched chicken eggs on plasma and tissue cholesterol and fatty acid composition of rats

Effects of dietary n−3 fatty acid‐enriched chicken eggs on plasma and tissue cholesterol and fatty acid composition of rats

Sex Differences in Steroid Retention and Excretion in Rats Fed Cholesterol

Pencegahan Lesi Aterosklerosis Oleh Asam Alfa Lipoat Pada Aorta Mencit Jantan (Mus Musculus) Yang Diberi Diet Tinggi Kolesterol

Contact Info

Product

Resources

About