Hypercoagulability Associated with Malignancy and the Postoperative State: Evidence of Elevated Antihemophilic Globulin-like Activity (AHG).

Amundsen, Melvin A.

doi:10.7326/0003-4819-56-4-683_3

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Changes In Factor VIII1

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1963

2006

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Cited by 14 publications

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“…Patients with malignant disease are at high risk for the development of deep vein thrombosis [6][7][8][9] , with reported prevalences of 7% to 26% in such patients 10,11 . The prevalence of deep vein thrombosis following hip replacement without prophylaxis in the general population has been estimated to range from 45% to 69% in various series 12 .…”

mentioning

confidence: 99%

Proximal Deep Vein Thrombosis After Hip Replacement for Oncologic Indications

Nathan

Simmons

Lin

et al. 2006

The Journal of Bone & Joint Surgery

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mentioning

confidence: 99%

Proximal Deep Vein Thrombosis After Hip Replacement for Oncologic Indications

Nathan

Simmons

Lin

et al. 2006

The Journal of Bone & Joint Surgery

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“…Nephrectomy alone evidently acts as a form of surgical stress, leading to a rise in Factor VIII as in human surgical patients (Egeberg, 1962). This is probably also the explanation for the acceleration of the thromboplastin generation test in patients with non-malignant disease after surgery (Amundsen, Spittell, Thompson and Owen, 1963). The failure of adrenaline to induce a further increase after nephrectomy suggests that the two forms of stress operate on a common mechanism which either can exhaust.…”

Section: Changes In Factor VIIImentioning

confidence: 96%

Changes in Factors V and VIII after Administration of Adrenaline to Normal and Splenectomized Rats

1969

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Summary: Changes in Factors V and VIII were studied in normal, unilaterally nephrectomized, and splenectomized rats. Adrenaline in a dose of 3 or 6 μg. per 200 g. body weight subcutaneously induced a significant but not very large increase in the activity of Factors V and VIII. A similar increase occurred in splenectomized and unilaterally nephrectomized rats. However, after unilateral nephrectomy an injection of adrenaline did not further raise the concentration of Factor VIII; and in Splenectomized rats a decrease in Factor VIII was found after adrenaline. The level of Factor V was not further significantly altered in either operated group after giving adrenaline. The mechanism of these changes is discussed but remains to be elucidated.

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