Hypercross-linked polystyrene and its potentials for liquid chromatography: a mini-review

Davankov, V. A.; Tsyurupa, M. P.; Ilyin, M. M.; Павлова, Л. А.

doi:10.1016/s0021-9673(01)01583-7

Cited by 96 publications

(44 citation statements)

References 15 publications

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“…Hypercrosslinked polymers are a new 107 generation of permanently porous, polymeric resins with enhanced analyte 108 retention characteristics arising from their high micropore contents and 109 correspondingly high specific surface areas (>1000 m 2 g -1 ) [13]. Recently, we 110 disclosed the synthesis of mixed-mode hypercrosslinked sorbents with weak 111 6 Darmstadt, Germany).…”

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confidence: 99%

Synthesis and application of hypercrosslinked polymers with weak cation-exchange character for the selective extraction of basic pharmaceuticals from complex environmental water samples

Bratkowska

Marcé

Cormack

et al. 2010

Journal of Chromatography A

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This version is available at https://strathprints.strath.ac.uk/27537/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the The synthesis of high specific surface area sorbents (HXLPP-WCX) in the form 39 of hypercrosslinked polymer microspheres with narrow particle size 40 distributions, average particle diameters around 6 µm, and weak cation 41

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confidence: 99%

Synthesis and application of hypercrosslinked polymers with weak cation-exchange character for the selective extraction of basic pharmaceuticals from complex environmental water samples

Bratkowska

Marcé

Cormack

et al. 2010

Journal of Chromatography A

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“…These therapies are based on nonspecifi c mechanisms such as hydrophobic interactions [10] and size exclusion [30] . Treatment for DRA consists primarily of symptomatic relief via anti-infl ammatory drugs, pain killers, surgery, use of ultrapurifi ed dialysate, and implementation of highly permeable and biocompatible membranes during the kidney replacement therapy [8,[44][45][46] to reduce the blood concentration of ␤ 2 m. The membrane properties that are important for ␤ 2 m removal during dialysis include permeability, adsorptive capacity and biocompatibility.…”

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confidence: 99%

“…This adsorbent column is based on proprietary hyper cross-linked styrene divinylbenzene co-polymer beads. The bead's pore size (2-20 Å) is suffi cient to remove molecules in the molecular weight range of 0.3-15.0 kDa [28][29][30] , a range which includes a broad spectrum of so called middle molecular weight toxins [11,26,27,31,32] . In August 2002, the device was entered into clinical trials in the USA.…”

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Assessment of the Stability of an Immunoadsorbent for the Extracorporeal Removal of Beta-2-Microglobulin from Blood

2005

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Background: Dialysis-related amyloidosis (DRA) is a devastating and costly condition that affects patients with end stage kidney disease. A key feature of DRA is the formation of amyloid fibrils, consisting primarily of β₂-microglobulin. Except for kidney transplantation, conventional kidney replacement therapies, which are based on nonspecific mechanisms, do not adequately address β₂-microglobulin removal. An antihuman β₂-microglobulin single-chain variable region antibody fragment (scFv) was developed to confer specificity to β₂-microglobulin removal during hemodialysis. Methods: The scFv was immobilized onto agarose and characterized for β₂m binding capacity, thermal stability at 37°C, regeneration capacity, storage conditions, and sterility. Results: The β₂-microglobulin binding capacity was 1.3 mg/ml scFv gel. The immunoadsorbent is thermally stable, can be regenerated, stored short-term in 20% ethanol, lyophilized for long-term storage, and withstand process conditions similar to that of a patient’s hemodialysis therapy. Conclusions: The results support further investigation of immobilized scFvs as a novel tool to remove β₂-microglobulin from blood.

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“…В этой связи мы попытались улучшить технологию SPE, заменив LiChroprep RP-18 на полимерный сорбент на основе сверхсшитого полистирола (Purosep-200). Этот отечественный сорбент обладает рядом уникальных свойств: сорбционная ёмкость в несколько раз превышает таковую у силикагеля, выдерживает рН от 0 до 14,0, одинаково эффективно сорбирует полярные и неполярные соединения, как из воды, так и из некоторых органических растворителей [4][5][6]. Кроме того, был заменен дериватизационный реагент -взамен ранее использовавшегося фенацил бромида, был апробирован 1-(бромоацетил)пирен, который ранее для этой цели не использовался [7].…”

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Modified hplc method of determination of the valproic acid in biological fluids

et al. 2013

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Proposed modified HPLC method for determination of valproic acid in biological fluids. Created solid-phase extraction of valproic and heptanoic acids (internal standard, IS) on the cartridges packed hyper cross-linked polystyrene which maintain some tens extractions without losses of efficiency. Carboxylic acids are derivative with 1-(bromoacetyl)pyrene in acetone at presence of triethylamine. Chromatographic separation of derivatives is performed on Chromolith Performance RP-18e columns, which packed unique monolithic sorbent. UV detection at 360 nm. Mobile phase acetonitrile – water (90:10, v/v) plus 1% isopropanol, speed flow 2000 microL/min, pressure 21 bar. Complete chromatographic cycle less than 3 minutes. Yield of IS and valproic acid (extraction plus derivatization) was 101-106%. Sensitivity (limit detection) was near 1 ng for valproic and near 0.6 ng for heptanoic acid during signal/noise ratio = 3.

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Hypercross-linked polystyrene and its potentials for liquid chromatography: a mini-review

Cited by 96 publications

References 15 publications

Synthesis and application of hypercrosslinked polymers with weak cation-exchange character for the selective extraction of basic pharmaceuticals from complex environmental water samples

Synthesis and application of hypercrosslinked polymers with weak cation-exchange character for the selective extraction of basic pharmaceuticals from complex environmental water samples

Assessment of the Stability of an Immunoadsorbent for the Extracorporeal Removal of Beta-2-Microglobulin from Blood

Modified hplc method of determination of the valproic acid in biological fluids

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