Hyperelastic mechanical behavior of chitosan hydrogels for nucleus pulposus replacement—Experimental testing and constitutive modeling

Sasson, Aviad Levi; Patchornik, Shachar; Eliasy, Rami; Robinson, Dror; Haj-Ali, Rami

doi:10.1016/j.jmbbm.2011.12.008

Cited by 66 publications

(38 citation statements)

References 24 publications

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“…Hyperelastic properties may provide a more accurate estimation of the nonlinear mechanical properties, especially when the loading rate is low. 43 The Yeoh hyperelastic model was used to define the nonlinear mechanical behavior of hydrogels. Results from the compression experimental tests were used to calibrate the strain energy function used for axial constitutive modeling.…”

Section: Resultsmentioning

confidence: 99%

“…The constitutive models discussed in this study are formulated in terms of the stretch along a direction of compression loading. 43 The hyperelastic constitutive model is used to describe materials that are able to undergo large, recoverable elastic strain such as rubber-like polymers and soft biological tissues. Under the assumption that hydrogel is an incompressible and isotropic material, 44 it was possible to fit a general polynomial isotropic strain energy function form (Eq.…”

Section: Constitutive Equationmentioning

confidence: 99%

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Influence of Poly(acrylic acid) on the Mechanical Properties of Composite Hydrogels

et al. 2014

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Gelatin (Gel) and poly(acrylic acid) (PAA) have so many applications in wound dressing, drug release, and tissue engineering on the basis of their easy availability, biocompatibility, and biodegradability. A composition of Gel/PAA hydrogel is widely used as a biological glue of soft tissues. However, the influence of PAA on the mechanical properties of this composite hydrogel so far has not been determined. In this study, gel hydrogels were prepared at various PAA content, i.e., 10, 20, and 30 wt%, using a thermal-initiated redox polymerization method. Afterward, as=prepared cylindrical hydrogel samples were subjected to a series of compressive loading to measure their linear elastic (elastic modulus, maximum stress and strain) and nonlinear hyperelastic (hyperelastic coefficients) mechanical properties. The potential ability of the Yeoh material model to closely address the nonlinear mechanical behavior of the hydrogel was verified using finite element (FE) modeling of the compression test. The results showed that the addition of PAA (>10 wt%) invokes a significant decrease in the Young's modulus and maximum stress of the hydrogels whereas (1 of 7)RESEARCH ARTICLE a significant increase in the maximum strain. The highest Young's modulus (25 MPa) and maximum stress (12 MPa) were observed in the hydrogels with PAA (10 wt%), whereas the highest maximum strain (43%) was detected in the Gel/PAA (30 wt%) samples. The experimental results were well compared to those anticipated by the Yeoh and FE models. The results suggested that an optimum addition of PAA not only could enhance the mechanical strength of the hydrogels but also provide a nonlinear behavior of composite hydrogels, which is suitable for soft tissue engineering. C 2014 Wiley Periodicals, Inc. Adv Polym Technol 2015, 34, 21487; View this article online at wileyonlinelibrary.com.

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Section: Resultsmentioning

confidence: 99%

Section: Constitutive Equationmentioning

confidence: 99%

Influence of Poly(acrylic acid) on the Mechanical Properties of Composite Hydrogels

et al. 2014

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“…For IVD replacement, the hydrogels must have properties such as the ability to support NP cell function, absorb shock, and tunable mechanical properties [26]. Chitosan hydrogel, due to its ability to maintain NP cell phenotype, is an attractive candidate for IVD regenerative engineering [154]. Degeneration of IVDs is a complex issue that can affect the disk as well as the area surrounding the region [153].…”

Section: Intervertebral Disk Regenerative Engineeringmentioning

confidence: 99%

“…For NP replacement, Sasson et al fabricated chitosan hydrogels and studied their hyperelastic mechanical behavior using mechanical testing and computational analysis. Results revealed that Ogden hyperelastic model can be used for representing the nonlinear behavior of chitosan hydrogel, and the model can be used for biomechanical simulation for the replacement of NP [154].…”

Section: Intervertebral Disk Regenerative Engineeringmentioning

confidence: 99%

Chitosan Hydrogels for Regenerative Engineering

Padmanabhan

Nair

2015

Springer Series on Polymer and Composite Materials

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Research in the field of hydrogels has been actively growing for the past couple of decades. Hydrogels are crosslinked polymers with high water content. They can be prepared from natural, synthetic, and composite polymers using different chemical and physical crosslinking methods. Hydrogels have been widely explored for the delivery of bioactive molecules, drugs, and for other therapeutic applications. Chitosan-based hydrogels have unique advantages owing to their biocompatibility, biodegradability, antimicrobial activity, mucoadhesivity, and low toxicity. This chapter reviews the different methods used for preparing chitosan-based hydrogels and their applications as cell, protein, and drug delivery vehicles to support tissue regeneration.

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“…Such computational models have the potential to design and introduce new biomaterial systems and to simulate their response to multiaxial loadings in order to obtain optimized materials and structures. For example, Sasson et al [27] have examined the hyperelastic behavior of chitosan gel for nucleus pulpous replacement using hyperelastic constitutive FE model to test other loading modes. Neal et al [28] have simulate the mechanical properties of poly(glycerol sebacate) (PGS) scaffold in different patterns in order to design desirable material properties for cardiac tissue scaffold.…”

Section: Introductionmentioning

confidence: 99%