Hypereosinophilia Syndrome: Myriad Presentation—A Case Report

Abstract

Hypereosinophilic syndrome is a myeloproliferative disorder that is distinguished with the presence of eosinophilia, which is an absolute eosinophil level of more than 1500/µL for no less than 6 months, no recognized cause for eosinophilia, and clear organ involvement characteristics. But, in some cases where patients require therapy to decrease eosinophil counts due to severe symptoms, a lower time period of hypereosinophilic is also admissible. In this case series, we have included three cases in which first case presented with the features of diarrhea, nausea, and decreased appetite who underwent colonoscopy and was diagnosed as a case of eosinophilic colitis. The second patient was a female came with abdominal pain and burning micturition, who was having eosinophilia on blood count examination and was diagnosed as a case of eosinophilic cystitis. Third case was young female who was diagnosed as eosinophilic endocarditis on two-dimensional echocardiography having dyspnea and rash and high eosinophil count on blood smear. All the three patients were started on steroids, who recovered well with medication and were discharged for follow-up after 7 days with complete blood count.

Concurrent Challenges in Idiopathic Hypereosinophilic Syndrome Complicating Beta-Thalassemia Major: A Case Report

“…Eosinophilia is a hallmark of HES, and its occurrence in this patient raises questions about the possible interplay between thalassemia-related pathophysiology and eosinophilic disorders [11]. Previous studies have proposed a potential link between thalassemia and eosinophilia, suggesting that chronic hemolysis and inflammation associated with thalassemia may contribute to releasing eosinophils from the bone marrow [12,13].…”

Unveiling Hypereosinophilia's Stealthy Grip on Cerebral Sinus Venous Thrombosis: A Silent Association

“…Eosinophils, constituting 3%-5% of circulating blood leukocytes, serve diverse functions in maintaining tissue homeostasis [1]. Eosinophilia encompasses both non-hematologic (reactive) and hematologic (clonal) disorders, potentially leading to end-organ damage [2]. Thrombosis represents a severe complication of HE, with approximately one-quarter of HES patients experiencing thromboembolic events, resulting in 5%-10% mortality [3].…”

Co-occurrence of Idiopathic Hypereosinophilic Syndrome in End-Stage Renal Disease Patients Undergoing Maintenance Hemodialysis

“…Idiopathic HES is a systemic disease characterized by persistent HE which results in multiple organ damage. It is diagnosed by the presence of HE (AEC ≥1,500/mL for more than a month), involvement of two or more organs, and the exclusion of secondary causes of eosinophilia such as malignancy, parasitic infection, and drug reaction [9].…”