Hyperferritinemia in patients with nonalcoholic fatty liver disease

Abstract

Objective: In liver diseases, hyperferritinemia (HYF) is related to injured cells in acquired and genetic conditions with or without iron overload. It is frequent in patients with nonalcoholic fatty liver disease (NAFLD), in which it is necessary to define the mean of HYF to establish the better approach for them. The present study evaluated the significance of elevated ferritin in patients with NAFLD and steatohepatitis (NASH). Method: The review was performed using search instruments of indexed scientific material, including MEDLINE (by PubMed), Web of Science, IBECS and LILACS, to identify articles published in Portuguese, English and Spanish, from 2005 to May, 2016. Studies eligible included place and year of publication, diagnose criteria to NAFLD, specifications of serum ferritin measurements and/or liver histopathologic study. Exclusion criteria included studies with patients with alcohol consumption ≥ 20 g/day and other liver diseases. Results: A total of 11 from 30 articles were selected. It included 3,564 patients and they were cross-sectional, retrospective, case series and case-control. The result's analyses showed in 10 of these studies a relationship between ferritin elevated serum levels and NAFLD/NASH with and without fibrosis and insulin resistance. Conclusion: Hyperferritinemia in patients with NAFLD/NASH is associated more frequently with hepatocellular injury than hemochromatosis. These data suggest the relevance to evaluate carefully HYF in patients with NAFLD/NASH to establish appropriate clinical approach.

Efficacy of canagliflozin against nonalcoholic fatty liver disease: a prospective cohort study

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Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome

“…Hyperferritinemia was more common among men, which could be related to a greater prevalence of NASH among this gender (Williams et al 2011, Barros et al 2017. Women also have lower iron storage due to menstrual loss, which may reflect a lower serum ferritin.…”

Neurociência, Aprendizagem E Ensino Superior: Abordagens De Estudos Que Influenciam Na Prática Acadêmica

“…Em face do exposto, é imprescindível ressaltar que a dosagem da ferritina, principal proteína envolvida no armazenamento do ferro, tem enorme significado na triagem de portadores de hemocromatose e outros desequilíbrios do ferro, a sangria terapêutica seria realizada nesses casos, vale ressaltar que a ferritina também se eleva em condições inflamatórias, doença hepática causada por vírus da hepatite B e C, doença hepática alcoólica, doença autoimune, entre outras. Portanto, tendo em vista os vários significados da elevação da ferritina, é necessária a sua interpretação correta, sendo avaliada juntamente com testes laboratóriais do metabolismo do ferro e teste molecular para detecção da mutação no gene HFE, contribuíndo para o estabelecimento da conduta terapêutica adequada (BARROS, 2017;ESPER, 2015;PETRONI, 2017;RODRIGUES, 2017). Em doenças em que ocorre a sobrecarga de ferro os homens são os mais acometidos em comparação com as mulheres.…”