Hyperfibrinolyse nach Reanimation bei akuter Lungenarterienembolie

Weber, Christian Friedrich; Wesselly, Ariane; Held, T.; Anheuser, Petra; Schönwälder, Jürgen; Weischer, Willem

doi:10.1055/a-1143-2825

Cited by 2 publications

(1 citation statement)

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“…Patients with high levels of PA are at a risk of systemic fibrinolysis and bleeding [7,8]. Hyperfibrinolysis is therefore one of the most common and important causes of massive blood loss in clinical practice [9,10]. Tranexamic acid (TXA), as a lysine analogue widely available in nature, is found to be an appropriate hemostatic drug.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Novel Tranexamic Acid/Montmorillonite Intercalation Composite, as a New Type of Hemostatic Material

Ma¹,

Sui

Yang³

et al. 2022

BioMed Research International

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Radiation enteritis—clinically manifested as diarrhea, intestinal bleeding, and so on—is frequently caused when the body is exposed to radiation or radiotherapy because the intestine is radiation-sensitive as an abdominal organ. Therefore, strategies to modulate intestinal hemostasis had inspired an important research trend in the process of preventing and treating radiation enteritis. Based on the structural characteristics of montmorillonite (MMT) and the hemostatic drug tranexamic acid (TXA) which was used clinically to treat enteritis, the tranexamic acid-montmorillonite composite material (TXA-MMT) was prepared through intercalation composite technology. According to the analysis of FTIR, XRD, TG-DTG, SEM, and XRF, the prepared TXA-MMT was verified that tranexamic acid could intercalate into layers of montmorillonite. To evaluate the biocompatibility, two experiments were conducted by in vitro hemolysis and in vitro cytotoxicity experiments and results showed that TXA-MMT exhibited good visible biocompatibility. Activated partial thromboplastin time, prothrombin time, and in vitro clotting time were adopted to determine the hemostatic effect of TXA-MMT. Compared with other groups, TXA-MMT revealed a significant decrease in clotting time variations, APTT, and PT. In addition, to investigate the preventive effect of TXA-MMT by the intervention of radiation enteritis mice, inflammatory factors IL-1β, IL-6, and TNF-α and the content of endotoxin in the serum of mice were detected. It demonstrated that TXA-MMT reduced the levels of these factors. Besides, the expression and the pathological changes of the small intestine tissue of mice were relieved. Our findings suggests that TXA-MMT as a promising intercalation composite has a great potential for application in the field of intestinal hemostasis.

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Section: Introductionmentioning

confidence: 99%