Muon spectroscopy offers a uniquely sensitive method for exploring many mechanisms in chemistry and chemical physics through the study of muonium, a probe species formed during muon implantation that is chemically equivalent to hydrogen. Next generation experiments in the field of muonium chemistry will require reliable liquid handling systems, in-situ experimental capabilities and access to advanced methods such as Radio-Frequency (RF) muon spin resonance spectroscopy. This paper discusses the development and commissioning of systems for sample handling, describing details of two liquid panels suitable for deoxygenation and transfer of liquid samples, the development of a centre stick for an existing 4 He flow cryostat suitable for RF muon chemistry experiments, a dedicated muon chemistry insert specifically optimized for RF liquid phase chemistry experiments, and a birdcage RF cavity optimized for high frequency measurements and with a geometry wellsuited for beamline experiments that exploit the chemistry insert. Example data is presented, demonstrating the application of these various pieces of equipment.