Hyperfixation diffuse de la graisse brune à la tomoscintigraphie par émission de positons couplée à la tomodensitométrie (TEP-TDM) dans l’exploration d’un phéochromocytome extra surrénalien

Ramacciotti, Carla Emilia; Schneegans, Olivier; Lang, Hervé; Lindner, Véronique; Claria, M.; Moreau, F.; Chenard, Marie-Pierrette; Pinget, M.; Kessler, L.

doi:10.1016/s0003-4266(06)72534-3

Cited by 15 publications

(2 citation statements)

References 18 publications

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“…The capacity of BAT to be recruited in humans, as in animals, is convincingly supported by the following data: (a) The existence of a reservoir of brown adipocyte/BAT progenitor cells in human muscle (CD34+) and WAT depots (hMADS; Crisan et al, 2008; Elabd et al, 2009); (b) Cold stimulates BAT activity and energy expenditure (thermogenesis) in humans (Huttunen et al, 1981; Cohade et al, 2003; Garcia et al, 2004, 2006; Christensen et al, 2006; Nedergaard et al, 2007; Saito et al, 2009; Van Marken Lichtenbelt et al, 2009); (c) Pheochromocytoma, a catecholamine-secreting tumor of the adrenal gland, has long been shown to cause increases in BAT mass and metabolic rate as well as leanness (Ricquier et al, 1982; Lean et al, 1986; Cannon and Nedergaard, 2004; Fukuchi et al, 2004; Ramacciotti et al, 2006). When the pheochromocytoma tumor is eliminated the high metabolic rate (BAT) subsides (Ramacciotti et al, 2006).…”

Section: Human Adults Have Functional Activatable Batmentioning

confidence: 99%

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Recruitment of Brown Adipose Tissue as a Therapy for Obesity-Associated Diseases

Boss¹,

Farmer²

2012

Front. Endocrin.

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Brown adipose tissue (BAT) has been recognized for more than 20 years to play a key role in cold-induced non-shivering thermogenesis (CIT, NST), and body weight homeostasis in animals. BAT is a flexible tissue that can be recruited by stimuli (including small molecules in animals), and atrophies in the absence of a stimulus. In fact, the contribution of BAT (and UCP1) to resting metabolic rate and healthy body weight homeostasis in animals (rodents) is now well established. Many investigations have shown that resistance to obesity and associated disorders in various rodent models is due to increased BAT mass and the number of brown adipocytes or UCP1 expression in various depots. The recent discovery of active BAT in adult humans has rekindled the notion that BAT is a therapeutic target for combating obesity-related metabolic disorders. In this review, we highlight investigations performed in rodents that support the contention that activation of BAT formation and/or function in obese individuals is therapeutically powerful. We also propose that enhancement of brown adipocyte functions in white adipose tissue (WAT) will also regulate energy balance as well as reduce insulin resistance in obesity-associated inflammation in WAT.

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Section: Human Adults Have Functional Activatable Batmentioning

confidence: 99%

“…When the pheochromocytoma tumor is eliminated the high metabolic rate (BAT) subsides (Ramacciotti et al, 2006). …”

Section: Human Adults Have Functional Activatable Batmentioning

confidence: 99%

Recruitment of Brown Adipose Tissue as a Therapy for Obesity-Associated Diseases

Boss¹,

Farmer²

2012

Front. Endocrin.

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Hybrid imaging of neuroendocrine tumors in the heart: Union is strength

Marketou

Kapsoritakis

Bourogianni

et al. 2023

Journal of Nuclear Cardiology

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Cardiac neuroendocrine tumors (NETs) are particularly rare tumors that can lead to a very poor clinical outcome, partly because of metastases but mainly because of manifestations of the hormonal activity they exhibit. Prompt diagnosis is important in order to start the most effective treatment for their removal or management, with the fewest complications. They are often difficult to diagnose, especially in their early stages. One of the reasons for this is that the heart is an organ with a high rate of metabolism and is located in close proximity to other highmetabolism organs. In addition, the anatomic location and their small size render their diagnosis extremely challenging. In recent years, hybrid imaging methods have revolutionized the diagnostic approach to oncology patients and have established a place in the diagnosis of cardiac NETs, because they provide both anatomical and functional information at the same time. Positron emission tomography/computed tomography (PET/CT), PET/magnetic resonance imaging (PET/MRI) and single-photon emission computed tomography/CT (SPECT/CT) are widely used in clinical practice because of the very important metabolic information, the high sensitivity and specificity. However, prospective studies are needed to confirm the true clinical and prognostic value of various hybrid imaging diagnostic techniques in cardiac NETs.

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Parties molles

Bennani-Smires¹

2022

TEP-TDM en Pratique

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Hyperfixation diffuse de la graisse brune à la tomoscintigraphie par émission de positons couplée à la tomodensitométrie (TEP-TDM) dans l’exploration d’un phéochromocytome extra surrénalien

Cited by 15 publications

References 18 publications

Recruitment of Brown Adipose Tissue as a Therapy for Obesity-Associated Diseases

Recruitment of Brown Adipose Tissue as a Therapy for Obesity-Associated Diseases

Hybrid imaging of neuroendocrine tumors in the heart: Union is strength

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