Hyperglicemia as Predisposition Factor of Oral Candidiasis on patient with Diabetes Mellitus

Nurmansyah, Dian; Stasya, Elma; Ramadhani, Dewi; Normaidah, Normaidah; Astuti, Aldiana

doi:10.31001/biomedika.v13i1.703

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Previous studies reported their findings on the positive correlation and influence of blood glucose level on oral candidiasis and Candida colonization. 30,31 However, our study did not reveal statistically significant differences between the controlled and uncontrolled subjects. This might corroborate a previous study that reported independency of Candida carriage prevalence from HbA1c level.…”

Section: Discussioncontrasting

confidence: 61%

Prevalence and identification of oral candida species in patients with type 2 diabetes in Yogyakarta

Agustina,

Chrisnawati,

Chrismawaty

et al. 2023

Majalah Kedokteran Gigi Indonesia

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Patients with diabetes are prone to recurring and even resistant Candidiasis, making treatment challenging. Many hypotheses proposed related to susceptibility of diabetic patients to Candida. The prevalence and species of Candida in a particular diabetic community might be different compared to other diabetic community. This study aimed to determine the prevalence of Candida colony and its species in the oral cavity of diabetic patients included in the CDM (Chronic Disease Management) program in Yogyakarta. One hundred patients with type 2 diabetes (n= 100) were recruited as the subjects of this study. The subjects were classified into controlled and uncontrolled Diabetes mellitus (DM). Samples of oral rinse solution were collected to determine the species of Candida and number of Candida colonies using CHROMagar Candida medium. There were 47 and 53 of subjects with controlled and uncontrolled DM, respectively. The mean number of Candida colony in the subjects with controlled diabetes (1003.13) was higher than that in the subjects with uncontrolled diabetes (478.43). The Candida colony most commonly identified in the subjects with controlled and uncontrolled diabetes were C. albicans and C. glabrata, respectively. Female patients had higher mean number of Candida colony (859.51) compared to male (299.21). The Candida colony most often identified in both genders was C. albicans. In addition, the subjects of this study consisted of 83 geriatric subjects and 17 non geriatric subjects, in which the mean number of Candida colony in the geriatric subjects (761.77) was higher than that in the non-geriatric subjects (545.71). The Candida colony most often identified in the geriatric subjects and non-geriatric subjects was C. albicans and C. glabrata, respectively. The Mann Whitney test demonstrated that there was a significant difference (p = 0.009) of the mean number of Candida colony between male and female. However, there was no significant difference of the mean number of Candida colony between ages (p = 0.060) and diabetic status (p=0.175). It can be concluded that the Candida species most commonly identified in all the subjects was Candida albicans with the mean colony number of 349.96, followed by C. glabrata (225.97), C. krusei (144.91), C. tropicalis (3.67), and other species (2.02).

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Section: Discussioncontrasting

confidence: 61%

Prevalence and identification of oral candida species in patients with type 2 diabetes in Yogyakarta

Agustina,

Chrisnawati,

Chrismawaty

et al. 2023

Majalah Kedokteran Gigi Indonesia

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A Case Report With Dual Diagnosis of Candidiasis in a Patient With Uncontrolled Diabetes Mellitus

Dadgal,

Mohod

2024

Cureus

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Chronic hyperglycemia is a hallmark of diabetes mellitus (DM), one of the most common endocrine illnesses affecting millions of people globally. A key issue for diabetes patients is a compromised immune system, which impairs their capacity to fight off invading microbes and increases their susceptibility to infections. Compared to the healthy population, those with DM experience noticeably longer recovery from illnesses or injuries. Individuals suffering from DM are more susceptible to Candida albicans colonizing their oral and/or vaginal mucosa and urinary system. The present article presented a case of a 52-year-old female patient who reported recurrent multiple plaque-like lesions with the underlying condition of hyperglycemia. The oral lesions were treated using the local application of clotrimazole gel and the discomfort subsided with Aceclofenac. The underlying condition was treated by a general physician who prescribed the tablet metformin 500mg. The patient was educated about the predisposing condition, and motivated to make some lifestyle changes and to maintain a proper diet.

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Hyperglicemia as Predisposition Factor of Oral Candidiasis on patient with Diabetes Mellitus

Cited by 2 publications

References 7 publications

Prevalence and identification of oral candida species in patients with type 2 diabetes in Yogyakarta

Prevalence and identification of oral candida species in patients with type 2 diabetes in Yogyakarta

A Case Report With Dual Diagnosis of Candidiasis in a Patient With Uncontrolled Diabetes Mellitus

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