Hyperglobulinemic Purpura Terminating in Myeloma, Hyperlipemia, and Xanthomatosis

Hyperglobulinemic Purpura in the Course of Multiple Myeloma

“…To the best of our knowledge only 2 cases have been reported in associa tion with MM confirmed by the presence of paraprotein and plasma cell infiltration of the bone marrow [6,7]. In one of these, the paraprotein was not identified, while in the other it was IgG type kappa.…”

“…The occurrence of HGP in the course of multiple myeloma (MM) is very rare and, to the best of our knowledge, only 2 cases have been reported [6,7], An additional case is described herein.…”

The Behavior of Immunoglobulin in Monoclonal Gammopathies and Their Classification and Pathogenesis

“…It seems especially important to assume the possibility that the latter phenomenon may be based on the former.88 In fact, there have been many reports of lymphoid tumors developing during the course of autoimmune diseases.62, 63,66,69 Cancer (II, 5): The appearance of M-components in association with malignant neoplasms of epithelial cell origin is well recognized.42,44,70,71 Such an association is not infrequent.…”

Therapy of Waldenström’s Benign Hypergammaglobulinaemia by Regular Plasmapheresis

“…A survey of 24 pa tients at one institution [11] confirmed the previously noted association of Walden strom's hypergammaglobulinaemic pur pura with collagen disease [6,8] -and ap proximately 50% of these patients deve loped evidence of Sjogren's syndrome, keratoconjunctivitis sicca, systemic lupus, or similar diseases. Occasional patients have been reported to eventually develop multiple myeloma [13,15]. However, the purpura and hypergammaglobulinaemia usually persist for many years without significant change or disease progression.…”