The Behavior of Immunoglobulin in Monoclonal Gammopathies and Their Classification and Pathogenesis

The Frequency of M-components in Sera of Patients with Solid Malignant Neoplasms

“…Migliore and Alexanian (1968) in their study did not encounter M-components of the IgA class, whereas the majority of the M-components found in patients with malignant neoplasms studied by Kanoh (1970) were of this class. This shows that there is no specific pattern in the immunoelectrophoretic results obtained by different investigators.…”

“…During the last two decades M-components have been detected in the sera of patients suffering from malignant lymphoma (Azar, Hill and Osserman, 1957;Krauss and Sokal, 1966;Moore et al, 1970), other forms of malignant disease (Osserman and Takatsuki, 1963;Hallen, 1966;Causey, 1967;Hosley, 1967;Migliore and Alexanian, 1968), and some non-malignant diseases (Owen, Pitney and O'Dea, 1959;Waldenstrom, 1964;Michaux and Heremans, 1969;Kanoh, 1970). In view of the fact that M-components have been observed in patients with malignant diseases, it was decided to study their frequency in the sera of patients with histologically proven solid malignant neoplasms attending our Institute.…”

Generalized Discoid Lupus Erythematosus With Benign Monoclonal Gammopathy

“…However, Kyle et al (8) described such a benign monoclonal condition as "potentially malignant" or "premyeloma", which should be followed up carefully. In the literature, benign monoclonal gammopathy is reported in several disorders, such as scleroderma diffusum (4), SLE (4, 5), Sjogren's syndrome (5,9) and also in dermatological diseases, such as bullous pemphigoid (10), Dermatitis ulcerosa (II), papular mucinosis (12), plane xanthomatosis (13) and even in normal persons (14,15). To our knowledge, however, there is no report of DLE III association and correltion with monoclonal gammopathy.…”

“…BMG is reported in some of SLE (4)(5)(6). A patient with g. DLE accompanying BMG is presented in this paper.…”