Hyperglycemia at admission is a strong predictor of mortality and severe/critical complications in COVID-19 patients: a meta-analysis

Abstract

Background: Hyperglycaemia at admission has been demonstrated to exacerbate the outcomes of coronavirus disease 2019 (COVID-19) but a meta-analysis is lacking to further confirm this hypothesis. The purpose of this meta-analysis was to summarize the evidence on the association between hyperglycaemia at admission and the development of COVID-19. Method: Four databases namely, PubMed, Web of Science, Embase and Cochrane Library, were screened for eligible studies. STATA software was utilized to pool data for this meta-analysis. The primary outcomes included mortality and severity. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with random-effects models, and the quality of evidence was appraised by the Newcastle-Ottawa Scale (NOS). This meta-analysis was prospectively registered online on PROSPERO, CRD42020191763. Results: Sixteen observational studies with 6386 COVID-19 patients relating hyperglycaemia at admission to COVID-19 outcomes were included. The overall data demonstrated that, compared with the control, the hyperglycaemia at admission group was more likely to have increased mortality (OR = 3.45, 95% CI, 2.26–5.26) and severe/critical complications (OR = 2.08, 95% CI, 1.45–2.99) of COVID-19. Conclusion: Hyperglycaemia at admission in COVID-19 patients may be a strong predictor of mortality and complications.

Association between Hyperglycemia at Hospital Presentation and Hospital Outcomes in COVID-19 Patients with and without Type 2 Diabetes: A Retrospective Cohort Study of Hospitalized Inner-City COVID-19 Patients

“…A growing number of observational studies have shown that hyperglycemia is a strong predictor of morbidity and mortality in hospitalized and critically ill COVID-19 patients, independent of pre-existing diabetes status [ 11 , 12 , 13 ]. However, it is still unclear how the combination of underlying T2D and the presence of hyperglycemia at the time of hospital admission is associated with the inflammatory burden and outcomes of COVID-19.…”

Associations and prognostic accuracy of electrolyte imbalances in predicting poor COVID-19 outcome: a systematic review and meta-analysis

“…[2] As majority of cases develop mild symptoms or are asymptomatic, [3,4] many have identified several risk factors associated with poor outcomes to better triage and allocate scarce health resources. [5][6][7][8][9][10][11] Recently, multiple observational studies reported the prevalence of electrolyte disorders amongst COVID-19 patients and have suggested its association with COVID-19 severity. [12,13] For example, Tzoulis et al found that adults with COVID-19 and dysnatremia was associated with a higher risk for mechanical ventilation and mortality in adults.…”

The prognostic role of hyperglycemia and glucose variability in covid-related acute respiratory distress Syndrome

“…In non critically ill patients, elevated glucose values were associated with a worse prognosis [14][15][16][17][18][19][20][21][22], but heterogeneity in study design can be detected in these investigations concerning study population (diabetics versus non diabetics) and blood glucose measurements (admission, fasting, in hospital glucose values). In a two-center retrospective investigation [17] (605 COVID patents without previous diagnosis of diabetes) fasting blood glucose (FBG 7.0 mmol/l) at admission was an independent predictor for 28-day mortality .…”