Hyperglycemia without diabetes and new-onset diabetes are both associated with poorer outcomes in COVID-19

Singh, Awadhesh Kumar; Singh, Ritu

doi:10.1016/j.diabres.2020.108382

Cited by 146 publications

(146 citation statements)

References 18 publications

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“… 32 The present results are in line with previous findings in which the role of hyperglycemia on COVID-19 patients’ prognosis was highlighted. 33 , 34 …”

Section: Discussionmentioning

confidence: 99%

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Nutritional Risk Screening and Body Composition in COVID‐19 Patients Hospitalized in an Internal Medicine Ward

Giorno¹,

Quarenghi²,

Stefanelli³

et al. 2020

IJGM

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Background Malnutrition in patients hospitalized in internal medicine wards is highly prevalent and represents a prognostic factor of worse outcomes. Previous evidence suggested the prognostic role of the nutritional status in patients affected by the coronavirus disease 2019 (COVID-19). We aim to investigate the nutritional risk in patients with COVID-19 hospitalized in an internal medicine ward and their clinical outcomes using the Nutritional Risk Screening 2002 (NRS-2002) and parameters derived from bioelectrical impedance analysis (BIA). Methods Retrospective analysis of patients with COVID-19 aimed at exploring: 1) the prevalence of nutritional risk with NRS-2002 and BIA; 2) the relationship between NRS-2002, BIA parameters and selected outcomes: length of hospital stay (LOS); death and need of intensive care unit (ICU); prolonged LOS; and loss of appetite. Results Data of 90 patients were analyzed. Patients at nutritional risk were 92% with NRS-2002, with BIA-derived parameters: 88% by phase angle; 86% by body cell mass; 84% by fat-free mass and 84% by fat mass (p-value ≤0.001). In ROC analysis, NRS had the maximum sensitivity in predicting the risk of death and need of ICU and a prolonged hospitalization showing moderate-low specificity; phase angle showed a good predictive power in terms of AUC. NRS-2002 was significantly associated with LOS (β 12.62, SE 5.79). In a multivariate analysis, blood glucose level and the early warning score are independent predictors of death and need of ICU (OR 2.79, p ≤0.001; 1.59, p-0.029, respectively). Conclusion Present findings confirm the clinical utility of NRS-2002 to assess nutritional risk in patients with COVID-19 at hospital admission and in predicting LOS, and that bioimpedance does not seem to add further predictive value. An early detection of nutritional risk has to be systematically included in the management of COVID-19 patients hospitalized in internal medicine wards.

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“… 32 The present results are in line with previous findings in which the role of hyperglycemia on COVID-19 patients’ prognosis was highlighted. 33 , 34 …”

Section: Discussionmentioning

confidence: 99%

“…32 The present results are in line with previous findings in which the role of hyperglycemia on COVID-19 patients' prognosis was highlighted. 33,34 We have to acknowledge several limitations in the present study. Firstly, the number of patients included in the analysis was small.…”

mentioning

confidence: 98%

Nutritional Risk Screening and Body Composition in COVID‐19 Patients Hospitalized in an Internal Medicine Ward

Giorno¹,

Quarenghi²,

Stefanelli³

et al. 2020

IJGM

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“…Impressively, this “new-onset” hyperglycaemia is not associated with any other risk factors, notably obesity, prediabetes, DM, or corticosteroid administration. These findings point to a bidirectional relationship between DM and COVID-19 [ 4 ].…”

Section: Editorialmentioning

confidence: 99%

New-Onset Diabetes in COVID-19: Time to Frame Its Fearful Symmetry

et al. 2020

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There is increasing evidence that coronavirus disease 2019 (COVID-19) may lead to new-onset diabetes mellitus (DM). This may occur even in patients without predisposing factors for impaired glucose metabolism. Both impaired pancreatic insulin secretion and insulin resistance have been implicated as underlying mechanisms. Importantly, new-onset hyperglycaemia is associated with worse prognosis in patients with COVID-19. Indeed, its prognosis may be even more sinister than in patients with pre-existing DM. More research data and knowledge are currently being collected to improve our insights into this constellation and to guide therapies in clinical reality.

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“…[4,5] Nevertheless, robust risk quantification of poor COVID-19 outcomes across wide array of admission BG levels has yet to be well-established. Furthermore, some studies have argued that the prognostic value of admission BG level is primarily driven by diabetes [6,7], while some others stated that the effect may be independent of diabetes history [8,9], thus emphasizing the need to establish a firm evidence on the current premises. Therefore, this review intends to summarize the current knowledge regarding the role of admission BG level in determining the prognosis of COVID-19 patients, thus contributing to risk stratification and patient management in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

High admission blood glucose independently predicts poor prognosis in COVID-19 patients: A systematic review and dose-response meta-analysis

Lazarus

Audrey

Wangsaputra

et al. 2021

Diabetes Research and Clinical Practice

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Highlights Admission fasting blood glucose (AFBG) independently predicts poor COVID-19 outcomes. Risk of COVID-19 severity rises by 33% for each 1 mmol/L increase in AFBG. There is high-quality evidence on the independent link between AFBG and severity. We found moderate-quality evidence linking AFBG with mortality and poor outcomes. Further researches on the independent prognostic value of admission random BG are required.

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Hyperglycemia without diabetes and new-onset diabetes are both associated with poorer outcomes in COVID-19

Cited by 146 publications

References 18 publications

Nutritional Risk Screening and Body Composition in COVID‐19 Patients Hospitalized in an Internal Medicine Ward

Nutritional Risk Screening and Body Composition in COVID‐19 Patients Hospitalized in an Internal Medicine Ward

New-Onset Diabetes in COVID-19: Time to Frame Its Fearful Symmetry

High admission blood glucose independently predicts poor prognosis in COVID-19 patients: A systematic review and dose-response meta-analysis

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