Hyperhomocysteinemia and myocardial remodeling in the sand rat, Psammomys obesus

Chaouad, B.; Moudilou, Elara; Ghoul, A.; Zerrouk, Fouzia; Moulahoum, Anissa; Othmani-Mecif, Khira; Cherifi, M.; Exbrayat, Jean-Marie; Benazzoug, Yasmina

doi:10.1016/j.acthis.2019.07.008

Cited by 10 publications

(13 citation statements)

References 65 publications

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“…The inhibition of collagen can significantly reduce ventricular remodeling. 23) In our study, Masson staining of SHR heart tissue demonstrated that Hhcy promoted changes and disorders in the structure of the interstitial and perivascular collagen networks, which is consistent with the results of animal studies 24) and clinical findings. 25) However, the FA intervention reversed the interstitial and perivascular fibrous collagen deposition.…”

Section: Discussionsupporting

confidence: 90%

Low Dose of Folic Acid Can Ameliorate Hyperhomocysteinemia-Induced Cardiac Fibrosis and Diastolic Dysfunction in Spontaneously Hypertensive Rats

et al. 2021

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To evaluate whether lowering plasma homocysteine (Hcy) levels at different doses of folic acid (FA) could reduce cardiac fibrosis and diastolic dysfunction in spontaneously hypertensive rats (SHRs) with hyperhomocysteinemia (Hhcy) and investigate the possible mechanism of action.We randomly divided 32 male SHRs into control, Hhcy, Hhcy + low-dose FA (LFA), and Hhcy + highdose FA (HFA) groups. Echocardiography and Masson staining of cardiac tissue were used to assess diastolic function and cardiac fibrosis. Blood pressure (BP) and Hcy levels were measured during the experiment. We also measured the indicators of oxidative stress (OS) and examined the expression of nuclear factor erythroid 2related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) genes and proteins using real-time polymerase chain reaction (PCR), immunohistochemistry, and western blotting to explore the possible mechanism of action.FA treatment reversed SHR cardiomyocyte interstitial and perivascular collagen deposition and diastolic dysfunction exacerbated by Hhcy. These effects were associated with promoting the translocation of Nrf2 from the cytoplasm to the nucleus, activating HO-1 expression and inhibiting OS. However, HFA did not show any additional benefit from LFA in reducing cardiac injury.Even at a low dose, FA can ameliorate Hhcy-induced cardiac fibrosis and diastolic dysfunction in SHRs by activating Nrf2/HO-1 pathway and inhibiting OS, independent of BP, providing evidence for the efficacy of LFA in the treatment of hypertension associated with Hhcy.

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Section: Discussionsupporting

confidence: 90%

Low Dose of Folic Acid Can Ameliorate Hyperhomocysteinemia-Induced Cardiac Fibrosis and Diastolic Dysfunction in Spontaneously Hypertensive Rats

et al. 2021

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“…Furthermore, we were able to locate 16 trials reporting cardiac fibrosis as a result of Hcy-induced oxidative stress [ 41 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. Several mechanisms of action have been proposed for this effect, including increased reactive oxygen species, nitrotyrosine, matrix metalloproteinase, and decreased endothelial nitric oxide in response to antagonizing PPAR-gamma [ 82 ] and regulation of the Akt/FoxO3 pathway.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, 11 trials were reported on cardiac remodeling because of hyperhomocysteinemia [ 60 , 61 , 62 , 63 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ]. Again, several mechanisms of action are postulated, including increased expression of transforming growth factor-beta1 (TGFβ1), a significant increase in the ratio of collagenous to non-collagenous protein due to reactive interstitial fibrosis, and increased myocardial oxidative stress, increased expression of matrix metalloproteinase-2, matrix metalloproteinase-9 and decreased expression of connexin 40, 43 and 45, and suppression of the Nrf2/HO-1 pathway and Nrf2 nuclear transport.…”

Section: Resultsmentioning

confidence: 99%

Homocysteine as a Predictor of Paroxysmal Atrial Fibrillation-Related Events: A Scoping Review of the Literature

et al. 2022

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High levels of homocysteine (Hcy) have been linked with adverse cardiovascular outcomes, such as arrhythmias and stroke. In the context of paroxysmal atrial fibrillation (PAF), hyperhomocysteinemia has been demonstrated to be an independent predictor of future events. The aim of this report was to address the potential value of Hcy levels in predicting future paroxysms of atrial fibrillation (AF), as well as to identify the potential mechanisms of action. We searched PubMed and the Cochrane Database on 16 January 2022. Keywords used were homocysteine or hyperhomocysteinemia paired with a total of 67 different keywords or phrases that have been implicated with the pathogenesis of AF. We included primary reports of clinical and non-clinical data in the English language, as well as systematic reviews with or without meta-analyses. We placed no time constraints on our search strategy, which yielded 3748 results. Following title review, 3293 reports were excluded and 455 reports were used for title and abstract review, after which 109 reports were finally used for full-text review. Our review indicates that Hcy levels seem to hold a predictive value in PAF. Herein, potential mechanisms of action are presented and special considerations are made for clinically relevant diagnostic procedures that could complement plasma levels in the prediction of future PAF events. Finally, gaps of evidence are identified and considerations for future clinical trial design are presented.

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“…It is an atherosensitive animal which would thus constitute an ideal model for the study of cardiovascular diseases [11,12]. We previously showed Hhcy to induce a myocardial remodeling including extracellular matrix in Psammomys obesus [13], but we did not address the effects of Hhcy on the other components of the cardiovascular system.…”

Section: Introductionmentioning

confidence: 97%

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Zerrouk

Chaouad

Ghoul

et al. 2022

Folia Histochem Cytobiol.

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. www.journals.viamedica.pl/folia_histochemica_cytobiologica ©Polish Society for Histochemistry and Cytochemistry Folia Histochem Cytobiol.

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Hyperhomocysteinemia and myocardial remodeling in the sand rat, Psammomys obesus

Cited by 10 publications

References 65 publications

Low Dose of Folic Acid Can Ameliorate Hyperhomocysteinemia-Induced Cardiac Fibrosis and Diastolic Dysfunction in Spontaneously Hypertensive Rats

Low Dose of Folic Acid Can Ameliorate Hyperhomocysteinemia-Induced Cardiac Fibrosis and Diastolic Dysfunction in Spontaneously Hypertensive Rats

Homocysteine as a Predictor of Paroxysmal Atrial Fibrillation-Related Events: A Scoping Review of the Literature

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

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