Hyperhomocysteinemia in Chronic Kidney Disease Patients in a Teaching Hospital in Nigeria

Olokor, Afeaje Benedicta; Ojogwu, Ikechukwu; Ugbodaga, Peter

doi:10.9734/bjmmr/2016/28282

Cited by 4 publications

(5 citation statements)

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“…From 91 patients included in the analyses, a number of 80 (87.9%) patients showed elevated plasma homocysteine level with the mean level of 23.17 mol. This results showed an even higher prevalence of hyperhomocysteinemia as compared to a study before [1] where the prevalence was only 57.9%. This study suggested that plasma homocysteine level would increase substantially among patients with chronic kidney disease (particularly those who received renal replacement therapy through hemodialysis).…”

Section: Discussioncontrasting

confidence: 55%

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Prevalence of elevated levels of homocysteine (hyperhomocysteinemia) in patients with chronic kidney disease undergoing hemodialysis

et al. 2019

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Background: Chronic kidney disease is a disease with kidney damage of more than 3 months. Chronic kidney disease has five stages, in which in the fifth stage the patient requires renal replacement therapy. Hemodialysis replaces kidney function to get rid of waste substances, this process can also reduce the substances that the body may still need such as vitamins that can be wasted. Even the metabolism in the body will be disrupted, one of which causes the balance of homocysteine metabolism to be disrupted. This causes homocysteine levels to increase in the plasma.Objectives: To measure the prevalence of elevated homocysteine levels (hyperomocysteinemia) in patients with chronic kidney disease who undergo hemodialysis.Methods and subjects: This is a cross sectional study with number of respondents in this study amounted to 91 people who all had chronic kidney disease undergoing hemodialysis at Bethesda Hospital and Panti Rapih Hospital in Yogyakarta. The selection of subjects used the consecutive sampling method. The data analysis used is univariate analysis.Results: Of the total 91 subjects with chronic kidney who undergo hemodialysis, 28.6% of them were elderly patients with an average age of 51.78 years, with men 59 subjects (64.8%) and women 32 subjects (35.2%). In all subjects got a history of hypertension and anemia 78 respondents (85.7%), diabetes 31 subjects (34.1%) and cancer 1 subjects (1.1%). The prevalence of subjects with hyperhomocysteinemia was 80 subjects (87.9%) and 11 were not (12.1%). In hyperhomocysteinemia patients (freq=80), 23 of them were elderly patients (88.5%), with men 55 subjects (93.2%) and women 25 subjects (78.1%). The history of the disease patients with hyperhomocysteinemia is anemia and hypertension 69 respondents (88.5%), diabetes 28 subjects (90.3%) and cancer 1 subject (100%). Conclusion:The prevalence of hyperhomocysteinemia in patients with chronic kidney disease undergoing hemodialysis is 87.9%.

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Section: Discussioncontrasting

confidence: 55%

“…A previous study involving 138 patients with chronic kidney disease in a Nigerian hospital showed the prevalence of hyperhomocysteinemia of 57.9% [1]. In Indonesia, particularly in Yogyakarta, the prevalence of hyperhomocysteinemia has never been studied thus far therefore, the authors intended to conduct this study.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of elevated levels of homocysteine (hyperhomocysteinemia) in patients with chronic kidney disease undergoing hemodialysis

et al. 2019

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“…For instance, the protein recommendations for adults in CKD stages 3–5 are 0.28–0.43 g/kg body weight daily with ketoanalogues or 0.55–0.60 g/kg body weight daily without ketoanalogues [ 14 , 16 ]. Considering that a low protein intake may lead to protein-energy malnutrition and cardiac-related death [ 6 , 17 , 18 , 19 ], dietary recommendations are for one to consume high-quality protein (e.g., eggs, chicken, red meat). This may lower DQ as, depending on how these foods are prepared, they may be high in saturated fats and sodium [ 12 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Relative Validity of the Chronic Kidney Disease Short Food Frequency Questionnaire (CKD SFFQ) to Determine Diet Quality and Dietary Habits among Adults with Chronic Kidney Disease

2021

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Limited instruments are available to determine diet quality among US adults with chronic kidney disease (CKD). The purpose of this study was two-fold: (1) to develop a food frequency questionnaire, CKD SFFQ, for adults with CKD and (2) to validate the CKD SFFQ against two 24-h recalls in determining diet quality (DQ). A 57-item CKD SFFQ was developed through a content validation method. Adults with CKD (n = 46) completed the CKD SFFQ and 2–24-h recalls. Statistical analyses included descriptive statistics, frequencies, t-tests, Pearson correlations, and Bland–Altman plots. All data were analyzed using JMP SAS v15 with statistical significance detected at p < 0.05. Results showed no differences for the overall DQ (p = 0.11) and the nine whole-food components (p = 0.07 to p = 0.44) when comparing the CKD SFFQ to the 2–24-h recalls. Pearson correlation coefficients ranged from −0.39 (refined grains) to 0.60 (greens and beans). Bland–Altman plots showed overall good agreement and there was a systematic trend towards higher estimates with the CKD SFFQ, particularly for overall DQ, total proteins, and dairy. The majority of participants rarely or never consumed grains, fruits, vegetables, seafood, and plant proteins. The CKD SFFQ was demonstrated to be an acceptable method to determine DQ for adults with CKD.

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“…There are several studies on CKD in Nigeria. [9][10][11] However, most of these studies are hospital based. This study reviews only published population-based studies that have information on the prevalence of CKD in Nigeria, and that also used the Kidney Disease Outcomes Quality Initiative (KDOQI) practice guidelines in defining CKD with emphasis on the performance of three estimating equations for GFR -the Modification of Diet in Renal Disease (MDRD), Cockcroft-Gault (CG), and CKD epidemiology collaboration (CKD-EPI) creatinine equation.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of chronic kidney disease in Nigeria: systematic review of population-based studies

Chukwuonye¹,

Anyabolu²,

Ohagwu³

et al. 2018

IJNRD

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BackgroundThe aim of this study was to identify and discuss published population-based studies carried out in Nigeria that have information on the prevalence of chronic kidney disease (CKD) and have also used the Kidney Disease Outcomes Quality Initiative (KDOQI) practice guidelines in defining CKD, with emphasis on the performance of three estimating equations for glomerular filtration rate (GFR) – Modification of Diet in Renal Disease (MDRD), Cock-croft–Gault, and CKD epidemiology collaboration (CKD-EPI) creatinine equation.Materials and methodsA systematic literature search was carried out in Google, MEDLINE, PubMed, and AJOL database, with the aim of identifying relevant population-based studies with information on the prevalence of CKD in a location in Nigeria.ResultsSeven cross-sectional population-based studies were identified. Two of the studies used the Cockcroft–Gault and observed a prevalence of 24.4% and 26%. Four of the studies used the MDRD and the prevalences observed were 12.3%, 14.2%, 2.5%, and 13.4%. One of the studies used the CKD-EPI equation and the prevalence was 11.4%. The male to female ratios of CKD prevalence in six studies were 1:1.9, 0.8:1, 1:1.6, 1:2, 1:1.8, 1:1.4, and the observed risk factors in the studies were old age, obesity, diabetes mellitus, hypertension, family history of hypertension, family history of renal disease, low-income occupation, use of traditional medication, low hemoglobin, and abdominal obesity.ConclusionThe prevalence of CKD was high but variable in Nigeria, influenced by the equation used to estimate the GFR. MDRD and CKD-EPI results are agreeable. There is a need for more population-based studies, with emphasis on repeating the GFR estimation after 3 months in subjects with GFR <60 mL/min/1.7 m2.

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Hyperhomocysteinemia in Chronic Kidney Disease Patients in a Teaching Hospital in Nigeria

Cited by 4 publications

References 0 publications

Prevalence of elevated levels of homocysteine (hyperhomocysteinemia) in patients with chronic kidney disease undergoing hemodialysis

Prevalence of elevated levels of homocysteine (hyperhomocysteinemia) in patients with chronic kidney disease undergoing hemodialysis

Development and Relative Validity of the Chronic Kidney Disease Short Food Frequency Questionnaire (CKD SFFQ) to Determine Diet Quality and Dietary Habits among Adults with Chronic Kidney Disease

Prevalence of chronic kidney disease in Nigeria: systematic review of population-based studies

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