Hypericin-loaded graphene oxide protects ducks against a novel duck reovirus

Du, Xiaxia; Xiao, Rong; Fu, Hualin; Yuan, Zhixiang; Zhang, Wei; Yin, Lizi; He, Chao; Li, Chuan‐Feng; Zhou, Jiewen; Liu, Guangqing; Shu, Gang; Chen, Zongyan

doi:10.1016/j.msec.2019.110052

Cited by 50 publications

(44 citation statements)

References 27 publications

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“…Only a few studies reported the broad spectrum antiviral activity of GO and GO-AgNP composites against viruses such as pseudorabies virus (PRV, a DNA virus), porcine epidemic diarrhea virus (PEDV, an RNA virus), 123 respiratory syncytial virus (RSV), 124 , 125 and Novel duck reovirus (NDRV). 126 …”

Section: Antimicrobial Agents and Finishesmentioning

confidence: 99%

Sustainable Personal Protective Clothing for Healthcare Applications: A Review

Karim

Afroj

Lloyd³

et al. 2020

ACS Nano

334

232

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Personal protective equipment (PPE) is critical to protect healthcare workers (HCWs) from highly infectious diseases such as COVID-19. However, hospitals have been at risk of running out of the safe and effective PPE including personal protective clothing needed to treat patients with COVID-19, due to unprecedented global demand. In addition, there are only limited manufacturing facilities of such clothing available worldwide, due to a lack of available knowledge about relevant technologies, ineffective supply chains, and stringent regulatory requirements. Therefore, there remains a clear unmet need for coordinating the actions and efforts from scientists, engineers, manufacturers, suppliers, and regulatory bodies to develop and produce safe and effective protective clothing using the technologies that are locally available around the world. In this review, we discuss currently used PPE, their quality, and the associated regulatory standards. We survey the current state-of-the-art antimicrobial functional finishes on fabrics to protect the wearer against viruses and bacteria and provide an overview of protective medical fabric manufacturing techniques, their supply chains, and the environmental impacts of current single-use synthetic fiber-based protective clothing. Finally, we discuss future research directions, which include increasing efficiency, safety, and availability of personal protective clothing worldwide without conferring environmental problems.

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Section: Antimicrobial Agents and Finishesmentioning

confidence: 99%

Sustainable Personal Protective Clothing for Healthcare Applications: A Review

Karim

Afroj

Lloyd³

et al. 2020

ACS Nano

334

232

View full text Add to dashboard Cite

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“…The antiviral properties of hypericin were shown against a large number of viruses including HIV, influenza virus A, herpes simplex, bovine diarrhea virus (BVDV), hepatitis C, duck reovirus, and bronchitis virus [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Hypericin seems to be particularly effective against enveloped viruses by targeting and modifying viral proteins [ 34 ].…”

Section: The Relevance Of Hyperforin Hypericin and Other Bioactivmentioning

confidence: 99%

The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum perforatum L., One of the Largest Medicinal Crops in Europe

Rizzo

Altschmied

Ravindran

et al. 2020

Genes

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Hypericum perforatum L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although H. perforatum produces several bioactive compounds, its importance is mainly linked to two molecules highly relevant for the pharmaceutical industry: the prenylated phloroglucinol hyperforin and the naphtodianthrone hypericin. The first functions as a natural antidepressant while the second is regarded as a powerful anticancer drug and as a useful compound for the treatment of Alzheimer’s disease. While the antidepressant activity of SJW extracts motivate a multi-billion dollar industry around the world, the scientific interest centers around the biosynthetic pathways of hyperforin and hypericin and their medical applications. Here, we focus on what is known about these processes and evaluate the possibilities of combining state of the art omics, genome editing, and synthetic biology to unlock applications that would be of great value for the pharmaceutical and medical industries.

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“…In China, NDRV has emerged in recent years and is a current common genotype [13,16]. Recently, a group of newly emerging DRVs [24][25][26] was confirmed and characterized in Cherry Valley duck in China [18]. The NDRV from the mainly infected ducklings caused and other avian reovirus strains based on the σC gene in the phylogenetic tree.…”

Section: Discussionmentioning

confidence: 99%

A TaqMan-based real-time PCR assay for specific detection of novel duck reovirus in China

Zhang

Liu

et al. 2020

BMC Vet Res

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Background: In China, Newly emerging duck reovirus (NDRV) variants have been causing major disease problems in cherry valley ducks. NDRV has the potential to cause high morbidity and 5-50% mortality rates. Severe hemorrhagic-necrosis in the liver and spleen were commonly seen in NDRV affected ducks. The availability of upgraded methods for rapid diagnosis of newly emerging DRV variants is crucial for successful DRV infection control and prevention. Results: In this study, we present a TaqMan-based real-time PCR assay (RT-qPCR) for the detection of NDRV infection. Using the conserved regions within the NDRV genome, we designed the specific primers and probe. The lower limit of detection for NDRV infection was 10 copies/μL (Ct values: 38.3) after the optimization of the RT-qPCR conditions. By cross-checking with other duck viral pathogens, no crossreactivity was observed confirming the assay was highly specific for the detection of NDRV. Reproducibility of the RT-qPCR was confirmed by intra-and inter-assay variability was less than 2.91%(Intra-assay variability of Ct values: 0.07-1.48%; Interassay variability of Ct values: 0.49-2.91%). This RT-qPCR and conventional PCR (cPCR) detected one hundred and twenty samples of NDRV infection from different regions. The result shows that the positive rates were 94.17 and 84.17% respectively. The detection rate of RT-qPCR rapid detection assay was 10% higher than that of the cPCR method. Conclusion: This research developed a highly sensitive, specific, reproducible and versatile of RT-qPCR for quantitatively detecting NDRV. It can be used to study the pathogenesis and epidemiology investigation of NDRV.

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Hypericin-loaded graphene oxide protects ducks against a novel duck reovirus

Cited by 50 publications

References 27 publications

Sustainable Personal Protective Clothing for Healthcare Applications: A Review

Sustainable Personal Protective Clothing for Healthcare Applications: A Review

The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum perforatum L., One of the Largest Medicinal Crops in Europe

A TaqMan-based real-time PCR assay for specific detection of novel duck reovirus in China

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