Hyperinsulinemia and circulating dehydroepiandrosterone sulfate in white and Mexican American women with polycystic ovary syndrome

Kauffman, Robert P.; Baker, Vicki M.; DiMarino, Pamela; Castracane, V. Daniel

doi:10.1016/j.fertnstert.2005.09.046

Cited by 40 publications

(26 citation statements)

References 52 publications

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“…The results of our study are consistent with previous studies reporting similar endocrine changes in FOH [2][3][4]. Previous studies had unequivocally documented the correlations of IR with hyperandrogenemia and elevated LH:FSH ratio [5][6][7][8][9]. This study also showed results comparable to these reports.…”

Section: Discussionsupporting

confidence: 93%

“…Chronic LH stimulation in FOH induces sustained hyper secretion of androgens by the theca compartment, probably augmented by insulin and insulin like growth factor [5]. Most data suggest that the primary defect may be at the ovarian level or all manifestations of the syndrome may occur secondary to hyperinsulinemia [6,7]. Insulin resistance (IR) is, thus the main factor involved in the pathophysiology of ovarian hyperandrogenism.…”

Section: Introductionmentioning

confidence: 99%

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Correlations of Insulin Resistance and Serum Testosterone Levels with LH:FSH Ratio and Oxidative Stress in Women with Functional Ovarian Hyperandrogenism

Suresh

Vijayakumar

2014

Ind J Clin Biochem

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Functional ovarian hyperandrogenism (FOH) is a form of polycystic ovary syndrome (PCOS) characterized by elevated circulating levels of androgens derived from the ovary. Insulin resistance (IR) is the most common etiological factor in women with FOH. IR causes the generation of increased oxidative stress (OS) and diminished antioxidant status. OS is directly correlated with both IR and testosterone levels, which consequently contribute to endocrine and biochemical alterations in FOH women. In the current study, elevations in total testosterone, free testosterone and luteinizing hormone (LH) levels accompanied by a decrease in follicle stimulating hormone (FSH) level leading to higher LH:FSH ratio were the prominent endocrine changes observed in women with FOH. A significant increase in fasting blood levels of glucose and insulin, as well as an elevated IR were also seen in FOH women, as compared to their age matched controls. Women with FOH have higher pro-oxidant and lower antioxidant levels in blood than their age matched controls. In FOH women, elevations in LH:FSH ratio and OS are correlated more with hyperandrogenemia than with IR. Of the androgens, free rather than total testosterone has better positive correlations with elevated LH:FSH ratio and OS, and hence, the former is a better predictive marker for the development of biochemical PCOS in women with FOH.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Correlations of Insulin Resistance and Serum Testosterone Levels with LH:FSH Ratio and Oxidative Stress in Women with Functional Ovarian Hyperandrogenism

Suresh

Vijayakumar

2014

Ind J Clin Biochem

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“…Recent human studies on the effect of hyperinsulinemia on AA production and metabolism have demonstrated divergent results (33)(34)(35)(36). These results may be due to the variability of the populations studied.…”

Section: Discussionmentioning

confidence: 99%

Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells

Pall

Nguyen

Magoffin

et al. 2009

Fertility and Sterility

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OBJECTIVE-To test the hypothesis that DHEAS production from DHEA occurs in hepatic cells, and that this production is augmented by the presence of sex steroids or insulin (INS). DESIGN-In-vitro prospective experimentSETTING-Academic medical center. RESULTS-DHEAS was first detected in the HepG2 cell culture media at 12h incubation. The cumulative production rate of DHEAS increased linearly until 72h incubation. When compared to the effect of treatment with DHEA only, treatment with DHEA plus T, DHT, or E2 delayed the cumulative DHEAS production; alternatively, the addition of INS did not alter DHEAS production. INTERVENTIONS-HepatomaCONCLUSION-These data suggest that while hepatic cells have the ability of converting DHEA to DHEAS, neither sex steroids nor INS result in the increased hepatic production of DHEAS.

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“…In some cross-population studies, however, significant endocrine differences have been observed. Mexican American women with PCOS are more insulin resistant and show higher incidences of insulin resistance than their European counterparts [24], as well as having lower circulating levels of dehydroepiandrosterone sulphate (DHEAS), an indicator of adrenal androgen production [11]. European women from Iceland have higher androstenedione, lower testosterone, less acne and are less hirsute than European women with PCOS from Boston, U.S. [25].…”

Section: Table 1 Herementioning

confidence: 99%

“…High levels of androgens also appear to be related to increased risk of cardiovascular disease, high insulin levels, and Type 2 diabetes [9,10]. In addition, hyperinsulinaemia can act to further stimulate ovarian androgen production, resulting in an interaction effect between hyperandrogenism and hyperinsulinaemia [8], although there is no evidence of a similar effect on adrenal androgens [11]. Obesity, observed in a large proportion of women with polycystic ovaries, exacerbates these endocrine disturbances.…”

Section: Introductionmentioning

confidence: 99%

Seasonality, Climatic Unpredictability, Food Deprivation, and Polycystic Ovary Syndrome

Shaw¹,

Elton²

2008

Society for the Study of Human Biology

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Hyperinsulinemia and circulating dehydroepiandrosterone sulfate in white and Mexican American women with polycystic ovary syndrome

Cited by 40 publications

References 52 publications

Correlations of Insulin Resistance and Serum Testosterone Levels with LH:FSH Ratio and Oxidative Stress in Women with Functional Ovarian Hyperandrogenism

Correlations of Insulin Resistance and Serum Testosterone Levels with LH:FSH Ratio and Oxidative Stress in Women with Functional Ovarian Hyperandrogenism

Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells

Seasonality, Climatic Unpredictability, Food Deprivation, and Polycystic Ovary Syndrome

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