Hyperinsulinemia and insulin resistance is associated with low T3/T4 ratio in pre diabetic euthyroid pakistani subjects

Farasat, Tasnim; Cheema, Abdul Majeed; Khan, Muhammad Naeem

doi:10.1016/j.jdiacomp.2012.05.017

Cited by 20 publications

(15 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our present findings, however, are not in agreement with those of Farasat et al [33], who reported that moderately high FT4 and TSH levels were significantly correlated with IR in subjects with IGT, a difference that may be due to differences in exclusion criteria (for example, exclusion of known diabetes in the present study). In addition, the results of that study were not adjusted for gender, abdominal obesity or PA, despite their importance to the aetiology of IR.…”

Section: Discussioncontrasting

confidence: 99%

Association between thyroid hormones, thyroid antibodies and insulin resistance in euthyroid individuals: A population-based cohort

Amouzegar

Davoodi

Gharibzadeh

et al. 2015

Diabetes & Metabolism

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 99%

Association between thyroid hormones, thyroid antibodies and insulin resistance in euthyroid individuals: A population-based cohort

Amouzegar

Davoodi

Gharibzadeh

et al. 2015

Diabetes & Metabolism

View full text Add to dashboard Cite

“…Given that this is an in vivo human study, we measured circulating neurotrophins instead of measuring the localized brain neurotrophins. Thyroxin, thyroid stimulating hormone [77–79], and gonadotropin levels [80, 81], which may be dysregulated by obesity and insulin resistance, were not assessed in this study and should be evaluated in follow-up studies. …”

Section: Discussionmentioning

confidence: 99%

Association of Obesity-Mediated Insulin Resistance and Hypothalamic Volumes: Possible Sex Differences

Cohen

Tirsi

et al. 2013

Disease Markers

View full text Add to dashboard Cite

The hypothalamus is important in hunger and metabolism. Although a lot is known about the basic role of the human hypothalamus, less is known about how the in vivo volume is affected in obesity, particularly among adolescents. Based on pediatric body mass index percentiles, 95 participants were assigned to lean or obese groups. All subjects had medical evaluations, including fasting blood tests, to assess insulin sensitivity and circulating CRP and neurotrophins (NGF and BDNF) and an MRI of the brain. Hypothalamic volumes were measured by a segmentation method combining manual and automated steps. Overall, obese participants had descriptively smaller hypothalamic volumes, although this difference did not reach statistical significance; however, among obese participants, females had significantly smaller hypothalamic volumes than their male counterparts. There was a significant interaction between insulin resistance and sex on hypothalamus volume; obese females with significant insulin resistance have smaller hypothalamic volumes than obese males. Obese adolescents had higher circulating CRP and neurotrophin levels. Furthermore, among obese females, BDNF concentrations were inversely associated with hypothalamus volumes (r = −0.48). Given this negative association between BDNF and hypothalamus volumes among obese insulin-resistant females, elevated neurotrophin levels may suggest an attempt at protective compensation.

show abstract

“…Circulating leptin levels rapidly fall after the decrease in insulin levels induced by streptozocin administration in rats and are acutely restored by insulin injection (Havel et al 1998). Previous studies confirm that a certain level of T3 is essential for normal glucose metabolism (Farasat et al 2012). Insulin resistance appears when thyroid levels are either too low or too high (Kapadia et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of glucose, insulin and triiodothyroxine on leptin and leptin receptor expression and the effects of leptin on activities of enzymes related to glucose metabolism in grass carp (Ctenopharyngodon idella) hepatocytes

Zhou

Yuan

et al. 2015

Fish Physiol Biochem

View full text Add to dashboard Cite

Leptin is an important regulator of appetite and energy expenditure in mammals, but its role in fish metabolism control is poorly understood. Our previous studies demonstrated that leptin has an effect on the regulation of food intake and energy expenditure as well as lipid metabolism (stimulation of lipolysis and inhibition of adipogenesis) in the grass carp Ctenopharyngodon idella. To further investigate the role of leptin in fish, the effects of glucose, insulin and triiodothyroxine (T3) on the expression levels of leptin and leptin receptor (Lepr) and the effects of leptin on the activities of critical glucose metabolism enzymes in grass carp hepatocytes were evaluated in the present study. Our data indicated that leptin gene expression was induced by glucose in a dose-dependent manner, while Lepr gene expression exhibited a biphasic change. A high dose of insulin (100 ng/mL) significantly up-regulated the expression of leptin and Lepr. Leptin expression was markedly up-regulated by a low concentration of T3 but inhibited by a high concentration of T3. T3 up-regulated Lepr expression in a dose-dependent manner. Together, these data suggest that leptin had a close relationship with three factors (glucose, insulin and T3) and might participate in the regulation of glucose metabolism in grass carp. In addition, we also found that leptin affected the activities of key enzymes that are involved in glucose metabolism, which might be mediated by insulin receptor substrate-phosphoinositol 3-kinase signaling.

show abstract

Hyperinsulinemia and insulin resistance is associated with low T3/T4 ratio in pre diabetic euthyroid pakistani subjects

Cited by 20 publications

References 42 publications

Association between thyroid hormones, thyroid antibodies and insulin resistance in euthyroid individuals: A population-based cohort

Association between thyroid hormones, thyroid antibodies and insulin resistance in euthyroid individuals: A population-based cohort

Association of Obesity-Mediated Insulin Resistance and Hypothalamic Volumes: Possible Sex Differences

Effects of glucose, insulin and triiodothyroxine on leptin and leptin receptor expression and the effects of leptin on activities of enzymes related to glucose metabolism in grass carp (Ctenopharyngodon idella) hepatocytes

Contact Info

Product

Resources

About