Hyperinsulinemia in polycystic ovary syndrome: relationship to clinical and hormonal factors

Vidal-Puig, António; Muñóz-Torres, Manuel; Jódar-Gimeno, Esteban; Garcia-Calvente, C.; Lardelli, Pablo; Ruiz-Requena, María Estrella; Escobar-Jiménez, Fernándo

doi:10.1007/bf00190740

Cited by 11 publications

(3 citation statements)

References 24 publications

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“…Our study aligns best with the view that the interplay between insulin and androgens is more than a simple causal relationship, and obesity likely plays an important role in attenuation of the risk conferred by hyperinsulinemia or hyperandrogenemia alone [44,48,49]. This has important implications for management since lifestyle modification in adolescents may yield more benefit in terms of reducing absolute, cumulative metabolic risk than therapies aimed solely at reducing androgen levels.…”

Section: Discussionsupporting

confidence: 62%

Phenotypic Characterization of Polycystic Ovary Syndrome in Adolescents Based on Menstrual Irregularity

Javed

Kumar²,

Simmons

et al. 2015

Horm Res Paediatr

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Objective: Polycystic ovary syndrome (PCOS) in adolescents is associated with adverse metabolic outcomes. The association of menstrual irregularity with metabolic risk among adolescents with PCOS was assessed. Method: A retrospective medical record review of 366 adolescents with PCOS aged 13-18 years was conducted, from which 265 girls newly diagnosed with PCOS were included and divided into those presenting with primary amenorrhea (PA), secondary amenorrhea (SA) and oligomenorrhea (OM). Androgen concentrations and markers of metabolic risk were compared among the groups. Results: Most subjects presented with OM (PA = 17, SA = 30 and OM = 218). Subjects with PA were younger than those with OM but not different from those with SA. Mean BMI was not different between groups. Total testosterone and insulin levels were higher in PA than SA and OM (p < 0.01 and 0.02, respectively). Fasting glucose was higher in PA than OM (p = 0.048) but not different from SA. Triglyceride levels were higher in PA than SA and OM (p < 0.001 each). More subjects with PA and SA had metabolic syndrome (52%) than those with OM (29.1%) (p = 0.027). The differences in triglycerides and glucose persisted despite BMI adjustment in multivariate regression models. Conclusion: Adolescents with PCOS presenting with PA are at risk of metabolic disease beyond expected based on BMI.

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Section: Discussionsupporting

confidence: 62%

Phenotypic Characterization of Polycystic Ovary Syndrome in Adolescents Based on Menstrual Irregularity

Javed

Kumar²,

Simmons

et al. 2015

Horm Res Paediatr

View full text Add to dashboard Cite

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“…But some failed to find such a relationship 21,17,22 . Hyperandrogenism and polycystic ovaries are commonly found in extreme IR 23,3 .…”

Section: Methodsmentioning

confidence: 99%

Characteristics of Insulin and Androgen Status in Polycystic Ovary Syndrome

Banu

Wahab

Debnath

et al. 2013

Bangladesh J Med Biochem

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hirsutism, acne or male pattern balding) and c) exclusion of hyperprolactinemia, nonclassical adrenal hyperplasia and thyroid disorders 1 . Burghen et al (1980) reported both basal and glucose stimulated hyperinulinemia in women with PCOS 2 . Many investigators found hyperinsulinemia and hyperandrogenemia are co-existent in PCOS 3 . IntroductionAccording to National Institute of Health (1990) ABSTRACTPolycystic Ovary Syndrome (PCOS) was originally described as a syndrome of amenorrhea, hirsutism and obesity associated with enlarged polycystic ovaries. There is increased androgen level and in some, insulin resistance (IR). Etiological relationship of androgen excess and IR in PCOS is not established. Influence of obesity on PCOS is controversial. This study was designed to see the androgen and insulin status in PCOS among obese and non-obese patients. It was a case-control study. Of total 80 study subjects, 60 primary infertile women suffering from PCOS were cases (30 obese and 30 non-obese). Age and BMI matched 20 healthy women having normal menstrual cycles were controls (10 obese and 10 non-obese). Age range of all were 20-40 years. Fasting plasma glucose, fasting S. Insulin and free Testosterone were measured. Insulin resistance (IR) was assessed by fasting glucose to insulin ratio (<4.5). Subjects with DM or known endocrine disorders that may be associated with abnormal S.Insulin or plasma glucose concentration were excluded. No significant difference of fasting plasma glucose between PCOS (obese or non-obese) and respective controls (P>0.5, in each) were observed. Significant difference of fasting S. Insulin and testosterone were observed between PCOS (both obese and non-obese) and respective controls (P<0.01 in each), but there was no significant difference between obese and non-obese PCOS (P>0.05). There was no significant difference of S.Testosterone between obese and non-obese PCOS(P>0.05). There was also no significant difference of IR between obese and non-obese PCOS, but the ratio was <4.5 (indicating IR in both). There were no significant correlation of S.Insulin with Testosterone in any group of PCOS (obese and non-obese) (P>0.05). Increased S.Insulin and Testosterone was seen in PCOS irrespective of BMI. Further studies with larger sample size is recommended to assess etiological relationship between insulin and testosterone in PCOS.

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“…Most researchers found a positive correlation between hyperinsulinema and hyperandrogenism. But some failed to find such a relationship 21,17,22 . Hyperandrogenism and polycystic ovaries are commonly found in extreme IR 23,3 .…”

Section: Serum Testosterone Was Significantly Increased In Pcos (Bothmentioning

confidence: 99%

Characteristics of Insulin and Androgen Status in Polycystic Ovary Syndrome

Banu

Wahab

Debnath

et al. 2013

Bangladesh J Med Biochem

View full text Add to dashboard Cite

hirsutism, acne or male pattern balding) and c) exclusion of hyperprolactinemia, nonclassical adrenal hyperplasia and thyroid disorders 1 . Burghen et al (1980) reported both basal and glucose stimulated hyperinulinemia in women with PCOS 2 . Many investigators found hyperinsulinemia and hyperandrogenemia are co-existent in PCOS 3 . ABSTRACTPolycystic Ovary Syndrome (PCOS) was originally described as a syndrome of amenorrhea, hirsutism and obesity associated with enlarged polycystic ovaries. There is increased androgen level and in some, insulin resistance (IR). Etiological relationship of androgen excess and IR in PCOS is not established. Influence of obesity on PCOS is controversial. This study was designed to see the androgen and insulin status in PCOS among obese and non-obese patients. It was a case-control study. Of total 80 study subjects, 60 primary infertile women suffering from PCOS were cases (30 obese and 30 non-obese). Age and BMI matched 20 healthy women having normal menstrual cycles were controls (10 obese and 10 non-obese). Age range of all were 20-40 years. Fasting plasma glucose, fasting S. Insulin and free Testosterone were measured. Insulin resistance (IR) was assessed by fasting glucose to insulin ratio (<4.5). Subjects with DM or known endocrine disorders that may be associated with abnormal S.Insulin or plasma glucose concentration were excluded. No significant difference of fasting plasma glucose between PCOS (obese or non-obese) and respective controls (P>0.5, in each) were observed. Significant difference of fasting S. Insulin and testosterone were observed between PCOS (both obese and non-obese) and respective controls (P<0.01 in each), but there was no significant difference between obese and non-obese PCOS (P>0.05). There was no significant difference of S.Testosterone between obese and non-obese PCOS(P>0.05). There was also no significant difference of IR between obese and non-obese PCOS, but the ratio was <4.5 (indicating IR in both). There were no significant correlation of S.Insulin with Testosterone in any group of PCOS (obese and non-obese) (P>0.05). Increased S.Insulin and Testosterone was seen in PCOS irrespective of BMI. Further studies with larger sample size is recommended to assess etiological relationship between insulin and testosterone in PCOS.

show abstract

Hyperinsulinemia in polycystic ovary syndrome: relationship to clinical and hormonal factors

Cited by 11 publications

References 24 publications

Phenotypic Characterization of Polycystic Ovary Syndrome in Adolescents Based on Menstrual Irregularity

Phenotypic Characterization of Polycystic Ovary Syndrome in Adolescents Based on Menstrual Irregularity

Characteristics of Insulin and Androgen Status in Polycystic Ovary Syndrome

Characteristics of Insulin and Androgen Status in Polycystic Ovary Syndrome

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