Hyperkinetic Disorders in Childhood

Sanger, Terence D.

doi:10.1007/978-1-60327-120-2_9

Cited by 2 publications

(1 citation statement)

References 167 publications

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“…The dyskinetic form is associated with acute partial hypoxic injury often at the time of term birth. 5 Dyskinetic CP can also be associated with several metabolic abnormalities including kernicterus that are known to affect basal ganglia, and possibly with vasculitis of lenticulostriate vessels in response to perinatal inflammatory processes. 6,7 The ataxic form of CP is often caused by developmental anomalies of the parietal lobes or posterior fossa, including malformations of the cerebellum.…”

Section: Introductionmentioning

confidence: 99%

Movement Disorders in Cerebral Palsy

Sanger

2015

J Pediatr Neurol

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Children with cerebral palsy often have a mixture of multiple disorders of movement that interact with each other and with the developmental process. While this complicates the process of symptomatic diagnosis, there is nevertheless a close link between clinical impairments and the underlying etiology and distribution of injury. I describe the major categories of impairment, including hypertonic symptoms, hyperkinetic symptoms, and negative signs. Within each category, there are specific features that are helpful for distinguishing between multiple impairments that affect motor function. Identification of the particular impairments affecting each child is essential to guide appropriate medical and rehabilitation interventions.

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Section: Introductionmentioning

confidence: 99%

Movement Disorders in Cerebral Palsy

Sanger

2015

J Pediatr Neurol

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Basic and Translational Neuroscience of Childhood-Onset Dystonia: A Control-Theory Perspective

Sanger

2018

Annu. Rev. Neurosci.

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Dystonia is a collection of symptoms with involuntary muscle activation causing hypertonia, hyperkinetic movements, and overflow. In children, dystonia can have numerous etiologies with varying neuroanatomic distribution. The semiology of dystonia can be explained by gain-of-function failure of a feedback controller that is responsible for stabilizing posture and movement. Because postural control is maintained by a widely distributed network, many different anatomic regions may be responsible for symptoms of dystonia, although all features of dystonia can be explained by uncontrolled activation or hypersensitivity of motor cortical regions that can cause increased reflex gain, inserted postures, or sensitivity to irrelevant sensory variables. Effective treatment of dystonia in children requires an understanding of the relationship between etiology, anatomy, and the specific mechanism of failure of postural stabilization.

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Hyperkinetic Disorders in Childhood

Cited by 2 publications

References 167 publications

Movement Disorders in Cerebral Palsy

Movement Disorders in Cerebral Palsy

Basic and Translational Neuroscience of Childhood-Onset Dystonia: A Control-Theory Perspective

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