2018
DOI: 10.1146/annurev-neuro-080317-061504
|View full text |Cite
|
Sign up to set email alerts
|

Basic and Translational Neuroscience of Childhood-Onset Dystonia: A Control-Theory Perspective

Abstract: Dystonia is a collection of symptoms with involuntary muscle activation causing hypertonia, hyperkinetic movements, and overflow. In children, dystonia can have numerous etiologies with varying neuroanatomic distribution. The semiology of dystonia can be explained by gain-of-function failure of a feedback controller that is responsible for stabilizing posture and movement. Because postural control is maintained by a widely distributed network, many different anatomic regions may be responsible for symptoms of … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

0
4
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 9 publications
(4 citation statements)
references
References 104 publications
0
4
0
Order By: Relevance
“…[13,14,21]. Manual lateralization was also approached from the perspective of neuroscience, which studies the connection between the functionality of the brain and the biological aspects of human performance and behavior [80][81][82]. Recent studies have demonstrated that there are close links between motor and sensory functions, which generate predictions for the formation of new motor experiences with different stimuli and in different training conditions [83,84].…”
Section: Discussionmentioning
confidence: 99%
“…[13,14,21]. Manual lateralization was also approached from the perspective of neuroscience, which studies the connection between the functionality of the brain and the biological aspects of human performance and behavior [80][81][82]. Recent studies have demonstrated that there are close links between motor and sensory functions, which generate predictions for the formation of new motor experiences with different stimuli and in different training conditions [83,84].…”
Section: Discussionmentioning
confidence: 99%
“…Although dystonia was originally classified as a hyperkinetic disorder, it shares features common to both hyperkinetic disorders (dyskinesia, Huntington's chorea) and hypokinetic disorders (rigidity, bradykinesia) (7). In children, a combination of parkinsonism and dystonia is typically present in conditions of low dopamine (e.g., dopa-responsive dystonia) or diffuse hypoxic injury (e.g., dyskinetic cerebral palsy) (26). EMG recordings from both Parkinsonism and dystonia demonstrate slow rates of contraction and change in contraction levels (27,28) and both Parkinsonism and dystonia have hyperkinetic components that can include tremor and dyskinesia.…”
Section: Discussionmentioning
confidence: 99%
“… 1 The mechanism underlying childhood dystonia is not fully understood but may include an imbalance between midbrain dopaminergic and striatal cholinergic signaling, 2 abnormal patterns of subcortical activity, excessive basal ganglia or peripheral loop gain, or decreased focusing of intended patterns of muscle activity. 3 , 4 , 5 Dystonia has been identified as the second most common movement disorder in pediatric patients with CP, 6 impacting motor function, and causing pain and discomfort. Cerebral palsy (CP) encompasses a heterogeneous group of developmental disorders with a movement disorder pattern that is diagnosed as dyskinetic CP.…”
Section: Introductionmentioning
confidence: 99%