Hyperlactataemia and hepatic steatosis: mitochondrial toxicity of nucleoside reverse transcriptase inhibitors

Pao, David; Watson, Christopher; Peters, Barry; Lucas, Sebastian; Miller, R F

doi:10.1136/sti.77.5.381

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…It could be observed from the result obtained in this study that normal dose of AZT, NVP and 3TC combination caused an abnormal morphology of the liver in which there was dilatation of the central vein of the liver. This may be due to the NVP present in the ARV which has been reported to be hepatotoxic [20] and also agrees with the finding of Pao et al, who reported development of fatty liver with mild portal inflammation following the administration of stavudine and abacavir in HIV infected patients. [20] There was an increment in the percentage of white blood cells caused by ARV administration, this may be due to the inflammatory reaction of some of the animal's organs and tissues to the ARV drug as compared to the control when administered daily for 3 weeks.…”

Section: Discussionsupporting

confidence: 91%

“…This may be due to the NVP present in the ARV which has been reported to be hepatotoxic [20] and also agrees with the finding of Pao et al, who reported development of fatty liver with mild portal inflammation following the administration of stavudine and abacavir in HIV infected patients. [20] There was an increment in the percentage of white blood cells caused by ARV administration, this may be due to the inflammatory reaction of some of the animal's organs and tissues to the ARV drug as compared to the control when administered daily for 3 weeks. [21] There was development of rashes on the snout of the animal one week into the study, these may be some of the tissue reaction to the highly toxic but potent ARV and also observed were some form of sluggishness among the animals.…”

Section: Discussionsupporting

confidence: 91%

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Effects of a Single Pill 3-drug Combination of Lamivudine, Nevirapine and Zidovudine on Blood Parameters and Liver Histology in Female Wistar Rats

Adewale¹,

Jubril²,

Oluwaseun³

et al. 2012

AJMMS

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Due to the stigma associated with HIV infection, HIV infected persons in Nigeria, have been found to remove the packs of their drugs and transferring the contents into non antiretroviral drug containers especially multivitamin containers, as a result unwary individuals have stumbled on such drugs and accidentally consumed it eventually leading to a host of complains such as dizziness, vague dreams, cramps etc. We therefore decided to study the effects of a single pill 3-drug combination of Lamivudine, Nevirapine and Zidovudine on the liver histology and blood parameters in the adult female rats. The rats were divided into two groups of 5 animals per group: one group received drug at a dose of 1.85mg/100g BW dissolved in normal saline while the control group received normal saline 0.5ml/100g BW for three weeks. From our observation we discovered that there was an aberration in liver histology of the experimental group in that the central vein was dilated as compared to the control group and also discovered that the drug had some effect on the blood parameters, which include among other things a significant decrease in PCV and a significant increase in WBC. The enlargement of the central vein of the liver observed in this study may be due to the presence of Nevirapine in the drug regimen and this may be of serious implication on liver function.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%