Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study

Frey, Noel; Hügle, Thomas; Jick, Susan S.; Meier, Christian; Spoendlin, Julia

doi:10.1016/j.joca.2017.01.014

Cited by 40 publications

(32 citation statements)

References 13 publications

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“…We also cannot rule out the idea that RA patients limit their manual activity and therefore diminish the mechanical stress on their osteoarthritic joints. The present study results favor the still-uncertain notion that obesity could be a risk factor for hand OA (17) by showing that patients with a higher BMI had a significantly higher risk of development and progression of DIP joint OA.…”

Section: Discussionsupporting

confidence: 81%

Influence of Disease Activity in Rheumatoid Arthritis on Radiographic Progression of Concomitant Interphalangeal Joint Osteoarthritis

Lechtenboehmer

Jaeger

Kyburz

et al. 2018

Arthritis & Rheumatology

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Section: Discussionsupporting

confidence: 81%

Influence of Disease Activity in Rheumatoid Arthritis on Radiographic Progression of Concomitant Interphalangeal Joint Osteoarthritis

Lechtenboehmer

Jaeger

Kyburz

et al. 2018

Arthritis & Rheumatology

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“…Eventually, after evaluation of the full texts, eight studies were excluded for the reason that they did not satisfy our inclusion criteria: three studies offered inadequate information [25][26][27], three studies did not offer ORs or RRs for OA or adequate information to calculate these variables [28][29][30], and two studies were removed that either did not have dyslipidemia as an exposure or did not have OA as an outcome [31,32]. Ultimately, nine available observational articles were recognized for our meta-analysis [33][34][35][36][37][38][39][40][41]. Table 1 presents the principal features of the studies included in the meta-analysis, all of which were observational studies.…”

Section: Study Selection and Studymentioning

confidence: 99%

“…The relationship between dyslipidemia and the risk of OA was investigated by three casecontrol studies [33,40,41]. Two case-control studies were population-based, and one case-control study was hospital based.…”

Section: Case-control Studiesmentioning

confidence: 99%

Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis

Xiong

Long

Chen

et al. 2020

BioMed Research International

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Background. According to several studies, the autoimmune response may lead to osteoarthritis and dyslipidemia and may affect the homeostasis of the human body’s internal environment and then cause its own immune regulation. Consequently, the risk of osteoarthritis might be increased by dyslipidemia, but this association is not universally acknowledged. Therefore, a systematic review and meta-analysis was conducted to study the relationship between dyslipidemia and the risk of osteoarthritis. Methods. In this study, PubMed, EMBASE, and the ISI Web of Science were used to identify related studies published before July 2018. The relationship between dyslipidemia and the risk of osteoarthritis was evaluated on the basis of relative risk (RR) values and the corresponding 95% confidence intervals (CIs). To further investigate this relationship, we also employed the random effects model proposed by DerSimonian and Laird. Results. A total of nine studies were included to study the effect of dyslipidemia on the risk of osteoarthritis, including four cohort, three case-control, and two cross-sectional studies. Among these studies, six stated data for knee osteoarthritis, two reported on hand osteoarthritis, and one reported on hip osteoarthritis. A total of 53,955 participants were included in the meta-analysis, comprising 22,501 patients with OA (19,733 hand OA, 2,679 knee OA, and 89 hip OA). Based on the meta-analysis of case-control and cross-sectional studies, osteoarthritis was clearly higher in those with dyslipidemia compared to those who did not suffer from dyslipidemia (case-control: OR=1.37; 95%CI=1.27–1.46; cross-sectional: OR=1.33; 95%CI=1.21-1.46). In addition, the meta-analysis of cohort studies did not present any relationship between dyslipidemia and OA (RR=1.00; 95%CI=0.85–1.14). Conclusions. Even though our meta-analysis of case-control and cross-sectional studies suggested a strong relationship between dyslipidemia and osteoarthritis; this relationship was not validated by our meta-analysis of only cohort studies. As a result, further investigation needs to be conducted on the relationship between dyslipidemia and osteoarthritis, considering the significant public health relevance of the topic.

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“…However, the role that metabolic factors play in the incidence and progression of hand OA is unclear, as little longitudinal research has been undertaken. Apart from one study that did not find an association between type 2 diabetes and incident hand OA (10), and two studies that examined hyperlipidaemia and incident hand OA with differing results (11,12), most studies have focused on obesity, and conflicting findings have been reported (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). The disparity in results could be due to variations in study populations and the definitions of progression used.…”

mentioning

confidence: 99%

Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study

Marshall

Peat

Nicholls

et al. 2018

Scandinavian Journal of Rheumatology

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Overall metabolic risk factors were not independently or collectively associated with greater amounts of radiographic hand OA incidence or progression over 7 years, but diabetes was associated with radiographic progression in nodal, and possibly generalized and erosive OA. Diabetes has previously been associated with prevalent but not incident hand OA. Further investigation in hand OA subsets using objective measures accounting for disease duration and control is warranted.

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Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study

Abstract: Our results suggest that hyperlipidaemia may be an independent risk factor for new onset HOA.

Cited by 40 publications

References 13 publications

Influence of Disease Activity in Rheumatoid Arthritis on Radiographic Progression of Concomitant Interphalangeal Joint Osteoarthritis

Influence of Disease Activity in Rheumatoid Arthritis on Radiographic Progression of Concomitant Interphalangeal Joint Osteoarthritis

Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis

Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study

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