Hypermotilinemia in Chronic Renal Failure

Shima, K; Tanaka, Aiko; Sawazaki, N; Hamabe, Jumpei; Tanaka, Ryosuke; Kumahara, Yuichi; Yanaihara, Noboru

doi:10.1055/s-0028-1095780

Cited by 7 publications

(4 citation statements)

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“…The present results confirmed the previous findings (Shima et al 1979) of elevated plasma IRM in patients with CRF. To our knowledge, no papers have been published as yet which describe elevated plasma IRM concentrations in patients with mechanical ileus.…”

Section: Discussionsupporting

confidence: 93%

“…Furthermore, it is reasonable to assume that hypermotilinemia may have something to do with the pathophysiology of this disease as the cause or effect, though the number of measurements was too small to draw any decisive conclusion on this matter. The mean IRM values of normal and azotemic plasma determined were slightly low compared with those reported previously (Shima et al 1979). This may be due, at least partly, to elimination of an influence of the plasma factors interfering with the assay system by addition of motilin-free plasma to the incubation mixture for a standard.…”

Section: Discussioncontrasting

confidence: 65%

“…Our previous report (Shima, Tanaka, Sawazaki, Hamabe, Tanaka, Kumahara and Yanaihara 1979) disclosed that in patients with chronic renal failure (CRF) plasma immunoreactive motilin (IRM) concentrations were raised to a level far exceeding those observed following a variety of physiological stimulations so far tested in man: duodenal acidification (Mitznegg, Bloom, Domschke, Domschke, Wiinsch and Demling 1976), ingestion of fat {Mitznegg, Bloom, Christofides, Besterman, Domschke, Domschke, Wiinsch and Demling 1976), etc. In addition, the hypermotilinemia associated with uremia was corrected by renal transplantation, but not by hemodialysis.…”

Section: Introductionmentioning

confidence: 99%

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Heterogeneity of Plasma Motilin in Patients with Chronic Renal Failure

Shima¹,

Shin²,

Tanaka³

et al. 1980

Horm Metab Res

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Plasma immunoreactive motilin (IRM) concentrations were strikingly higher in patients with chronic renal failure (CRF) than in normal subjects. IRM in azotemic plasma was heterogeneous in gel-filtration profile. The first peak eluted in the void volume of the column and the second and the third one, comprising a major portion of IRM content, came out coincidentally with insulin and authentic motilin, respectively. By contrast, no discernible amount of IRM was found in the region corresponding with the second peak in gel-filtration of the plasma from normals and very little in a patient with ileus whole plasma IRM level was elevated. The hypermotilinemia and the accumulation of this high molecular weight motilin in patients with CRF suggest that the kidney plays some role in the elimination of motilin, and further, that the clearance of the high molecular motilin is more dependent on renal function than that of authentic motilin. The present paper emphasizes the necessity for clarifying the significance of the heterogeneity of IRM in CRF.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Heterogeneity of Plasma Motilin in Patients with Chronic Renal Failure

Shima¹,

Shin²,

Tanaka³

et al. 1980

Horm Metab Res

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show abstract

“…Motilin, as well as other gut hormones, has been considered to be inactivated by the kidney (Shima et al 1979). However, diabetics investigated in this study except those with nephropathy showed the normal renal function.…”

Section: Discussionmentioning

confidence: 99%