Hypernatremia Associated with Severe Rhabdomyolysis

Acquarone, N; Garibotto, Giacomo; Pontremoli, Roberto; Gurreri, G

doi:10.1159/000185349

Cited by 18 publications

(9 citation statements)

References 6 publications

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“…Rhabdomyolysis has been associated with both hypernatremia 11 and hyponatremia 12 particularly in the hyperosmolar state 13 . Our study confirmed these associations.…”

Section: Discussionsupporting

confidence: 87%

Occult Elevation of CK as a Manifestation of Rhabdomyolysis in the Elderly

Marcus¹,

Rudensky²,

Sonnenblick³

1992

J American Geriatrics Society

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“…Rhabdomyolysis has been associated with both hypernatremia 11 and hyponatremia 12 particularly in the hyperosmolar state 13 . Our study confirmed these associations.…”

Section: Discussionsupporting

confidence: 87%

Occult Elevation of CK as a Manifestation of Rhabdomyolysis in the Elderly

Marcus¹,

Rudensky²,

Sonnenblick³

1992

J American Geriatrics Society

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“…In some cases there was an association with germinoma, pinealoma, optic glioma or cerebral ischaemia. Diabetes insipidus was present in only a few cases (2,6,8,9). In this case, in addition to dehydration, the patient complained of intense pain and muscular weakness.…”

Section: Discussionmentioning

confidence: 73%

Severe rhabdomyolysis due to adipsic hypernatremia after craniopharyngioma surgery

Zantut-Wittmann

Garmes

Panzan

et al. 2007

Arq Bras Endocrinol Metab

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The association of diabetes insipidus and adipsia after craniopharyngioma surgery has high morbidity. Hypernatremia can be caused by adipsia and be aggravated by diabetes insipidus. Rhabdomyolysis rarely occurs. Case report: This is the first report of a diabetic patient with craniopharyngioma who developed diabetes insipidus and adipsia after surgery, evolving with severe hypernatremia that caused considerable rhabdomyolysis. Conclusion: The importance of the evaluation of muscle integrity when under hypernatremic states is pointed out. Although adipsia may have a simple solution through volunteer water ingestion, serious consequences such as repeated severe hypernatremia episodes and intense rhabdomyolysis with high morbidity could occur, if adipsia is not diagnosed. A associação de diabetes insipidus e adipsia após cirurgia de craniofaringioma implica em alta morbidade. Hipernatremia pode desenvolver-se devido a adipsia e ser agravada por diabetes insipidus. Rabdomiólise raramente ocorre. Descrição do caso: Esta é a primeira descrição de paciente diabético com craniofaringioma que desenvolveu diabetes insipidus e adipsia após a cirurgia, evoluindo com hipernatremia grave e conseqüente rabdomiólise maciça. Conclusão: Ressalta-se a necessidade de avaliar a integridade muscular na vigência de estados hipernatrêmicos. Apesar de apresentar solução simples, como ingestão voluntária de água, pode haver sérias conseqüências se o diagnóstico de adipsia não é realizado, como episódios repetidos de hipernatremia grave com rabdomiólise intensa e elevada morbidade. with craniopharyngioma, leading to increased morbidity. Adipsia or hypodipsia rarely occurs as a hypothalamic lesion. The association of these two osmolarity dysfunctions causes a significantly higher morbidity (1). Hypernatremia can emerge from adipsia and be aggravated by diabetes insipidus. Clinical manifestations include dehydration, muscular weakness, behavioural disturbances, apresentação de caso

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“…11,47 The risk of using mannitol is the occurrence of volume overload if renal failure develops, in spite of the above-mentioned treatment. 12,[51][52][53] The last measure is the maintenance of therapy and the monitoring of clinical and laboratory data. 16 The only drawback of bicarbonate administration is the decrease of serum ionized calcium 1 and its deposition in soft tisues.…”

Section: Discussionmentioning

confidence: 99%