Hyperoside: A review on its sources, biological activities, and molecular mechanisms

Abstract

Hyperoside is a natural flavonol glycoside in various plants, such as Crataegus pinnatifida Bge, Forsythia suspensa, and Cuscuta chinensis Lam. Medical research has found that hyperoside possesses a broad spectrum of biological activities, including anticancer, anti‐inflammatory, antibacterial, antiviral, antidepressant, and organ protective effects. These pharmacological properties lay the foundation for its use in treating multiple diseases, such as sepsis, arthritis, colitis, diabetic nephropathy, myocardial ischemia–reperfusion, pulmonary fibrosis, and cancers. Hyperoside is obtained from the plants and chemical synthesis. This study aims to provide a comprehensive overview of hyperoside on its sources and biological activities to provide insights into its therapeutic potential, and to provide a basis for high‐quality studies to determine the clinical efficacy of this compound.

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

“…Among them, further investigation is required to evaluate the role of Hyp as an active constituents of Artemisia capillaris —a well-known herbal plant frequently used for treating liver disease [ 104 ]. In addition, based on above medicinal plants containing Hyp, further studies on efficient and economic extraction methods maximizing the purity and yield are needed [ 14 , 95 ]. Hence, Hyp may be an active compound present in various herbal plants that can be widely applied in clinical settings owing to its hepatoprotective, antiviral, antisteatotic, anti-inflammatory, antifibrotic, and anticancer activities.…”

“…It is reported that the genera Hypericum , Arbutus , Abelmoschus , Zanthoxylum , Houttuynia , etc. are rich in Hyp, and it has been extracted from over 30 herbal plants [ 14 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

“…The isolation of Hyp from medicinal plant extracts mostly used ethanol solvent and the extraction methods of reflux and ultra-sonication with a range of purity from 1.91–91.41% [ 14 ]. As depicted in Figure 1 , the molecular structure of Hyp is composed of multiple polar groups that include one carbonyl group, three ether linkages, and eight hydroxyl groups [ 25 ].…”

“…According to recent studies, a few studies have investigated the safety of Hyp [ 14 , 95 ]. In 40 healthy BALB/c mice, Hyp treatment (5,000 mg/kg, intragastrical route once) did not result in mouse poisoning, death, acute toxicity, or genotoxicity [ 96 ].…”

“…Hyp has been known to be derived from many herbal plants, including Crataegus pinnatifida , Abelmoschus manihot , Hypericum perforatum , Geranium carolinianum , Zanthoxylum bungeanum , the flowers of Acacia melanoxylon , Rosaceae , Rhododendraceae , Werspearaceae , and Leguminosae [ 11 , 12 , 13 , 14 ]. As a potential medicinal constituent, Hyp has been reported to possess a wide range of pharmacological activities against lung cancer, cardiac injury, renal injury, lung fibrosis, and diabetes [ 15 , 16 , 17 ].…”