Hyperoxia may be related to delayed cerebral ischemia and poor outcome after subarachnoid haemorrhage

Jeon, Sang Beom; Choi, H. Alex; Badjatia, Neeraj; Schmidt, J. Michael; Lantigua, Hector; Claassen, Jan; Connolly, E. Sander; Mayer, Stephan A.; Lee, Ki-Won

doi:10.1136/jnnp-2013-307314

Cited by 80 publications

(80 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[2][3][4]19,20 In a large retrospective cohort study, Rincon et al 4 found a statistically significant association between extreme hyperoxemia and in-hospital mortality in a mixed stroke population. The association was also evident in the subgroup including only SAH patients.…”

Section: Comparison With Previous Studiesmentioning

confidence: 98%

Early Moderate Hyperoxemia Does Not Predict Outcome After Aneurysmal Subarachnoid Hemorrhage

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Comparison With Previous Studiesmentioning

confidence: 98%

Early Moderate Hyperoxemia Does Not Predict Outcome After Aneurysmal Subarachnoid Hemorrhage

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Hyperoxia is also found to worsen neurological outcomes in a rat model of traumatic brain injury with hemorrhagic shock [47]. Other clinical studies have confirmed that hyperoxia is independently correlated with long-term poor neurological outcomes and in-hospital mortality among patients with brain injury [48, 49]. Therefore, excessive oxygen is a major factor mediating Hb-induced neurotoxicity.…”

Section: Discussionmentioning

confidence: 96%

An Intersectional Study of LncRNAs and mRNAs Reveals the Potential Therapeutic Targets of Buyang Huanwu Decoction in Experimental Intracerebral Hemorrhage

Cui

Liu

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Both experimental and clinical studies have revealed satisfactory effects of the traditional Chinese formula Buyang Huanwu decoction (BYHWD) in improving post-intracerebral hemorrhage (ICH) neurological deficiencies. However, the multifaceted mechanisms of BYHWD in ICH treatment are not comprehensively understood. The present study explored various therapeutic targets of BYHWD by using lncRNA and mRNA transcriptomics. Methods: LncRNA and mRNA microarrays were used to identify differentially expressed genes. ICH-induced upregulated genes (ICH vs sham) and BYHWD-induced downregulated genes (BYHWD vs ICH) were first identified. The intersection between these 2 sets was determined to identify ICH-induced highly expressed genes that were reversed by BYHWD. Then, the genes downregulated after ICH and the genes upregulated after BYHWD treatment were used to generate another set of intersections. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were subsequently performed to determine relative biological functions and signaling transduction pathways according to genes within the intersections. Quantitative real-time PCR was used to validate changes in gene expression observed using the microarray. Finally, a lncRNA-mRNA co-expression network was established to identify links among the genes within the intersections. Results: A total of 18 differentially expressed lncRNAs and 33 differentially expressed mRNAs were identified using 2 lncRNA arrays (ICH vs sham and BYHWD vs ICH). The altered genes were enriched in the hemoglobin complex, oxygen transport and oxygen transporter and were closely associated with pyruvate metabolism. The co-expression network consisted of 53 nodes and 595 connections (308 positive interactions and 287 negative interactions). Conclusion: The hemoglobin complex, oxygen transport, oxygen transporter activity and pyruvate metabolism are possible therapeutic targets of BYHWD in ICH treatment. The present study provides the basis and direction for future investigations to explore the mechanisms by which BYHWD protects against long-term neurological deficiencies after ICH.

show abstract

“…Comparing 80% oxygen to 30% oxygen we detected a reduced point estimate in long‐term survival without stroke and TCI, although this was likely caused by reduced mortality. In patients with preexisting thrombosis, hyperoxia may worsen neurological outcome and decrease long‐term survival through above mentioned mechanisms . Ronning et al reported higher mortality in patients with minor or moderate stroke receiving high level oxygen compared to no oxygen supplement, and suggested that only hypoxic stroke patients should receive supplemental oxygen.…”

Section: Discussionmentioning

confidence: 99%

Association between perioperative hyperoxia and cerebrovascular complications after laparotomy—A post‐hoc follow‐up study

Kongebro

Jørgensen

Siersma

et al. 2018

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

Hyperoxia may be related to delayed cerebral ischemia and poor outcome after subarachnoid haemorrhage

Cited by 80 publications

References 36 publications

Early Moderate Hyperoxemia Does Not Predict Outcome After Aneurysmal Subarachnoid Hemorrhage

Early Moderate Hyperoxemia Does Not Predict Outcome After Aneurysmal Subarachnoid Hemorrhage

An Intersectional Study of LncRNAs and mRNAs Reveals the Potential Therapeutic Targets of Buyang Huanwu Decoction in Experimental Intracerebral Hemorrhage

Association between perioperative hyperoxia and cerebrovascular complications after laparotomy—A post‐hoc follow‐up study

Contact Info

Product

Resources

About