Hyperparathyroidism induced by hypothyroidism

Walker, Rob; Oslapas, Raymond; Ernst, K; Hessel, Patricia; Nayyar, R. P.; Lawrence, A. M.; Paloyan, Edward

doi:10.1288/00005537-199303000-00005

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…In our previous study, limited to 12 weeks of observation, we demonstrated parathyroid hyperplasia in 95% of the animals treated with PTU and a 30% increase in the circulating PTH levels 32 . These findings lent support to the hypothesis that chronic hypothyroidism may lead to the development of hyperparathyroidism.…”

Section: Discussionsupporting

confidence: 74%

“…The hyperplastic changes i n the parathyroids of the PTUtreated rats did not appear to be due only to the direct effect of PTU on parathyroid tissue, because these changes were not seen in the euthyroid animals treated with both PTU and thyroxine. 32 These preliminary results led to this long-term study to determine whether a full hyperparathyroid state could be produced in chronically hypothyroid rats.…”

Section: Introductionmentioning

confidence: 99%

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Hyperparathyroidism Associated With a Chronic Hypothyroid State

et al. 1997

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Reports of the coexistence of hyperparathyroidism and thyroid disease have raised the issue of a possible etiologic relationship. The present study tests the hypothesis that chronic elevation of thyroid-stimulating hormone (TSH) is related to the development of hyperparathyroidism. Four groups of 60 female rats were treated as follows: group 1, control; group 2, propylthiouracil (PTU) 0.0025%; group 3, PTU 0.0025% plus thyroxine, 5 microg two times per week; and group 4, only thyroxine. The animals' serum calcium, phosphorus, TSH, thyroxine, and parathyroid hormone (PTH) levels were evaluated at 0, 6, 12, and 18 months. Significant elevation of TSH was sustained throughout the 18 months in groups 2 and 3. The PTH levels were also significantly elevated in both group 2 and group 3 animals (P = 0.02). The histopathologic features of the parathyroids were evaluated at 18 months. In the group 2 (PTU only) animals, which had profound hypothyroid, 44% developed parathyroid adenomas. In the group 3 (PTU plus thyroxine) animals, who had mildly elevated TSH levels, 53% developed parathyroid adenomas. These findings are consistent with the hypothesis that prolonged TSH stimulation may lead to hyperparathyroidism in the rat model.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Hyperparathyroidism Associated With a Chronic Hypothyroid State

et al. 1997

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“…8 This has been demonstrated in the rat model, with experimental elevation of thyroid-stimulating hormone (TSH) leading to significant concurrent elevations in PTH and subsequent development of parathyroid adenomas. 9,10 Alternatively, hypothyroid dogs may have smaller thyroid gland size, possibly leading to more mobility of the parathyroid nodule and subsequent difficulty with correct needle placement during parathyroid ablation. However, the effect of thyroid size was not seen when considering all dogs that underwent parathyroid ablation.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Factors Affecting Outcome of Ultrasound‐guided Radiofrequency Heat Ablation for Treatment of Primary Hyperparathyroidism in Dogs

Bucy

Pollard

Nelson

2016

Vet Radiology Ultrasound

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Radiofrequency (RF) parathyroid ablation is a noninvasive treatment for hyperparathyroidism in dogs. There are no published data assessing factors associated with RF parathyroid ablation success or failure in order to guide patient selection and improve outcome. The purpose of this retrospective analytical study was to determine whether imaging findings, biochemical data, or concurrent diseases were associated with RF heat ablation treatment failure. For inclusion in the study, dogs must have had a clinical diagnosis of primary hyperparathyroidism, undergone cervical ultrasound and RF ablation of abnormal parathyroid tissue, and must have had at least 3 months of follow-up information available following the date of ultrasound-guided parathyroid ablation. Dogs were grouped based on those with recurrent or persistent hypercalcemia and those without recurrent or persistent hypercalcemia following therapy. Parathyroid nodule size, thyroid lobe size, nodule location, and presence of concurrent disease were recorded. Recurrence of hypercalcemia occurred in 9/32 dogs that had ablation of abnormal parathyroid tissue (28%) and one patient had persistent hypercalcemia (3%) following parathyroid ablation. Nodule width (P = 0.036), height (P = 0.028), and largest cross-sectional area (P = 0.023) were larger in dogs that had recurrent or persistent hypercalcemia following ablation. Hypothyroidism was more common in dogs with recurrent disease (P = 0.044). Radiofrequency ablation was successful in 22/32 (69%) dogs. Larger parathyroid nodule size and/or concurrent hypothyroidism were associated with treatment failure in dogs that underwent ultrasound-guided RF parathyroid nodule ablation.

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“…Two studies in rats using propylthiouracil to stimulate TSH showed that chronic TSH stimulation led to parathyroid hyperplasia and an increase in circulating PTH. It is postulated that prolonged TSH stimulation and may lead to hyperparathyroidism in animal models 36 37…”

Section: Discussionmentioning

confidence: 99%

Primary hyperparathyroidism due to an intrathyroidal parathyroid adenoma associated with chronic lymphocytic thyroiditis

Cating-Cabral

Cabungcal²,

Villafuerte³

et al. 2012

BMJ Case Reports

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This is a case of a 44-year-old woman with an anterior neck mass and hypothyroidism who presented with an incidental finding of an elevated serum calcium level and was found to have primary hyperparathyroidism and osteoporosis. During surgical exploration no parathyroid adenoma was found, although a nodule was palpated within the right thyroid lobe. Examination of the excised right thyroid lobe revealed an intrathyroidal parathyroid adenoma and chronic lymphocytic thyroiditis. After surgery, she did not develop severe hypocalcaemia and this was attributed to preoperative treatment with pamidronate. In the months following surgery, parathyroid hormone remained undetectable.

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Hyperparathyroidism induced by hypothyroidism

Cited by 7 publications

References 19 publications

Hyperparathyroidism Associated With a Chronic Hypothyroid State

Hyperparathyroidism Associated With a Chronic Hypothyroid State

Analysis of Factors Affecting Outcome of Ultrasound‐guided Radiofrequency Heat Ablation for Treatment of Primary Hyperparathyroidism in Dogs

Primary hyperparathyroidism due to an intrathyroidal parathyroid adenoma associated with chronic lymphocytic thyroiditis

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