Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype

Pavlovsky, Lev; Mimouni, Daniel; Amitay‐Laish, Iris; Feinmesser, Meora; David, Michael; Hodak, Emmilia

doi:10.1016/j.jaad.2011.06.023

Cited by 42 publications

(52 citation statements)

References 39 publications

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“…Most patients in the study group followed a protracted, relatively benign course in accord with classical CD4 MF. The findings herein convincingly indicate CD8 + MF to be indistinguishable from the usual CD4 + form of disease, differing only in the single immunophenotypical anomaly; furthermore, they are in agreement with previous authors who contend that CD8 expression, in and of itself, cannot be taken to imply a poor prognosis . The same assertion has been made with regard to the CD4 − /CD8 − variant of otherwise typical MF and CD56 + disease .…”

Section: Discussionsupporting

confidence: 92%

Aggressive epidermotropic cutaneous CD8⁺ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. Report of an EORTC Cutaneous Lymphoma Task Force Workshop

et al. 2015

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Section: Discussionsupporting

confidence: 92%

Aggressive epidermotropic cutaneous CD8⁺ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. Report of an EORTC Cutaneous Lymphoma Task Force Workshop

et al. 2015

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“…44,45 Cases expressing CD8 or that are CD4/CD8 double-negative have been reported, and do not seem to behave differently from CD4 + cases. [46][47][48][49][50][51][52][53] Expression of cytotoxic markers by neoplastic cells in MF increases with progression from plaque stage to tumoral stage disease. 54 Here we report 2 cases of MF expressing TCR-g, 1 in the tumoral stage that was CD4 À / CD8 À and that expressed perforin, and another in the plaque stage, with large cell transformation that was CD30 + /CD8 + and that expressed cytotoxic markers intensively.…”

Section: Discussionmentioning

confidence: 99%

TCR-γ Expression in Primary Cutaneous T-cell Lymphomas

Rodríguez‐Pinilla

Ortiz‐Romero²,

Monsálvez³

et al. 2013

American Journal of Surgical Pathology

125

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Primary cutaneous γδ T-cell lymphomas (PCGD-TCLs) are considered a subgroup of aggressive cytotoxic T-cell lymphomas (CTCLs). We have taken advantage of a new, commercially available antibody that recognizes the T-cell receptor-γ (TCR-γ) subunit of the TCR in paraffin-embedded tissue. We have analyzed a series of 146 primary cutaneous T-cell lymphomas received for consultation or a second opinion in the CNIO Pathology Department. Cases were classified according to the World Health Organization 2008 classification as mycosis fungoides (MF; n=96), PCGD-TCLs (n=5), pagetoid reticulosis (n=6), CD30(+) primary cutaneous anaplastic large cell lymphomas (n=5), primary cutaneous CD8 aggressive epidermotropic CTCLs (n=3), primary cutaneous CTCL, not otherwise specified (n=4), and extranodal nasal-type NK/T-cell lymphomas primarily affecting the skin or subcutaneous tissue (n=11). Sixteen cases of the newly named lymphomatoid papulosis type D (LyP-D; n=16) were also included. In those cases positive for TCR-γ, a further panel of 13 antibodies was used for analysis, including TIA-1, granzyme B, and perforin. Clinical and follow-up data were recorded in all cases. Twelve cases (8.2%) were positive for TCR-γ, including 5 PCGD-TCLs, 2 MFs, and 5 LyP-Ds. All 5 PCGD-TCL patients and 1 MF patient died of the disease, whereas the other MF patient and all those with LyP-D were alive. All cases expressed cytotoxic markers, were frequently CD3(+)/CD8(+), and tended to lose CD5 and CD7 expressions. Eight of 12 and 5 of 11 cases were CD30(+) and CD56(+), respectively. Interestingly, 5/12 TCR-γ-positive cases also expressed TCR-BF1. All cases analyzed were negative for Epstein-Barr virus-encoded RNA. In conclusion, TCR-γ expression seems to be rare and is confined to cytotoxic primary cutaneous TCLs. Nevertheless, its expression is not exclusive to PCGD-TCLs, as TCR-γ protein can be found in other CTCLs. Moreover, its expression does not seem to be associated with bad prognosis by itself, as it can be found in cases with good and bad outcomes.

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“…in a younger age group in Fitzpatrick Type IV skin with CD8 + predominant cells. [17] However, two patients with hyperpigmented MF in our study were in their sixties with cells demonstrating CD4 + and CD8 − .…”

Section: Discussionmentioning

confidence: 75%

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

et al. 2016

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Background:Little data are available concerning clinical and pathological patterns of cutaneous lymphomas in India.Aim:To analyze the clinical and histopathological characteristics of cutaneous lymphomas in Indian patientsMaterials and Methods:This is a single-center, prospective, observational study carried out from January 1, 2010, to December 31, 2015. The patients underwent clinical examination, human T-cell lymphotropic virus-1 (HTLV-1) screening, skin biopsy with hematoxylin and eosin and immunohistochemistry staining.Results:Among 35 cases, 33 (94.3%) were T-cell, and 2 (5.7%) were B-cell lymphomas. The mean age was 52.66, and the male to female ratio was 2.5:1. The most common types of T-cell lymphomas included mycosis fungoides (MF) (57.1%) followed by adult T-cell lymphoma/leukemia (ATL) (17.1%). Primary cutaneous peripheral T-cell lymphoma not otherwise specified was diagnosed in 17.1% and anaplastic large cell lymphoma in 2.9%. The morphological types of MF included polymorphic, poikilodermatous, folliculotropic, hypopigmented, hyperpigmented, mixed, and purpuric. Skin manifestations of ATL included ulcerated plaques and erythroderma. Epidermotropism was very marked in ATL (83.3%) than in MF (70%). Larger Pautrier's microabscess was noted in ATL compared to smaller ones in MF. Markedly dense, diffuse infiltrate of atypical cells was noted in ATL in contrast to mild to moderate nodular or perivascular infiltrate in MF. ATL had an extremely poor prognosis.Limitations:Identification of DNA integration of HTLV-1 by Southern blot could not be analyzed, and the number of cases studied is limited.Conclusions:The study showed unique patterns of subtypes of cutaneous lymphomas in our country. Variations in the clinical pattern and histopathological analysis will help to differentiate T-cell lymphoma types which have prognostic implications.

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Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype

Cited by 42 publications

References 39 publications

Aggressive epidermotropic cutaneous CD8⁺ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. Report of an EORTC Cutaneous Lymphoma Task Force Workshop

Aggressive epidermotropic cutaneous CD8⁺ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. Report of an EORTC Cutaneous Lymphoma Task Force Workshop

TCR-γ Expression in Primary Cutaneous T-cell Lymphomas

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

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Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype

Cited by 42 publications

References 39 publications

Aggressive epidermotropic cutaneous CD8+ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. Report of an EORTC Cutaneous Lymphoma Task Force Workshop

Aggressive epidermotropic cutaneous CD8+ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. Report of an EORTC Cutaneous Lymphoma Task Force Workshop

TCR-γ Expression in Primary Cutaneous T-cell Lymphomas

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

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Aggressive epidermotropic cutaneous CD8⁺ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. Report of an EORTC Cutaneous Lymphoma Task Force Workshop

Aggressive epidermotropic cutaneous CD8⁺ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. Report of an EORTC Cutaneous Lymphoma Task Force Workshop