Hyperplasia and Hypertrophy of Pacinian Corpuscles

Abstract

The proliferation of Pacinian corpuscles is a rare benign lesion that occurs frequently in the fingers of hands, with the only clinical sign of pain when a drastic temperature change happens. A case of an extremely rare lesion in which we observed hypertrophy and hyperplasia of Pacinian corpuscles has been reported.

Pacinian Corpuscles in the Human Fetal Finger and Thumb: A Study Using 3D Reconstruction and Immunohistochemistry

“…The histology of Pacinian corpuscles has often been reported routinely in relation to various pathologic conditions in the skin of adult hands (e.g., Barbolini et al, 1971;Greider and Flatt, 1982;Komforti and Cummings, 2015;Garcia et al, 2015). A comprehensive evaluation of adult human corpuscles by routine histologic methods showed a highly wavy or coiled appearance (Cauna and Mannan, 1958).…”

Pacinian corpuscle hyperplasia in a 6‐year‐old girl

“…PCs in the hand are distributed in branches of digital nerve in the fingers, near the metacarpophalangeal joints, and in the thenar eminence. In a previous study, most patients were middle‐aged females, and the distribution of PCH in order of frequency was the second digit, distal palm/web spaces, first digit, and toe 3 . Since PCH can be a rare cause of finger pain, it should be considered in the differential diagnosis of a patient with a progressive tender nodule on the hand after trauma, even in children.…”

“…In a previous study, most patients were middle-aged females, and the distribution of PCH in order of frequency was the second digit, distal palm/web spaces, first digit, and toe. 3 Since PCH can be a rare cause of finger pain, it should be considered in the differential diagnosis of a patient with a progressive tender nodule on the hand after trauma, even in children. Accordingly, histopathologic differential diagnosis of PCH in children includes enlarged/altered PCs in association with glomus tumor, neurofibroma, and palmar fibromatosis (Dupuytren's contracture).…”

Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review

“…Surgical treatment (excision) is helpful in relieving symptoms (81%), while recurrence occurs in 21% of cases. For these patients, multiple revision surgeries are performed and, occasionally, amputation of the finger is necessary (Chavoin et al., 1980; Garcia et al., 2015; Hart et al., 1971; Kojima et al., 1977).…”

“…Our findings confirm that Rhode’s Type B represents the most common form of PCNH (Jones and Eadie, 1991; Patterson, 1956; Vaes and De Smet, 2003) and prove previous reports wrong, which referred to Reznik’s Type 2, which is a cluster (hyperplasia) of normal sized Pacinian corpuscles, as the most common type (Rinaldi et al., 2000). Little is known about the prognostic value of such classifications (Garcia et al., 2015). The terms ‘Pacinian neuroma’, ‘Pacinian hypertrophy’, and ‘Pacinian hyperplasia’ have been used interchangeably in the past and in some recent articles, regardless of the presence or absence of trauma, which is misleading (Cho et al., 2012; Jiménez et al., 2017; Kenmochi et al., 2006; Lang-Stevenson, 1984; Mahipathy et al., 2015; Narayanamurthy et al., 2005; Patterson, 1956; Rhode and Jennings, 1975; Schuler and Adamson, 1978; Zanardi et al., 2011).…”