Hyperplastic Changes and Receptor Status in the Breast Tissue of Bodybuilders Under Anabolic?androgenic Steroid Stimulation

The ovarian steroid hormone estradiol and its metabolite estrone were examined in 45 normal women and 127 premenopausal women with precancerous cervical lesions. Interviews, colposcopy and cervical scrapings were performed. The mean +/- SD values for estradiol and estrone were 0.07 +/- 0.08 ng/ml and 0.06 +/- 0.02 ng/ml, respectively in normal subjects. Corresponding data in patients with cervical intraepithelial neoplasia alone or in association with human papillomavirus (HPV) infection were 0.074 +/- 0.03 ng/ml and 0.076 +/- 0.03 ng/ml or 0.080 +/- 0.03 ng/ml and 0.148 +/- 0.02 ng/ml, respectively, which revealed a significantly greater extent of estrogenic action in the latter population (p < 0.05). We considered that the presence of HPV infection probably increased 16 alpha-hydroxylation of estradiol, providing a possible link between the viral and hormonal elements, possibly having a bearing on the etiology of the disease.

show abstract

Relationship between estradiol 16α-hydroxylation and human papillomavirus infection in cervical cell transformation

Salazar

Mercado

Sojo

et al. 2001

DGYE

View full text Add to dashboard Cite

show abstract

Relationship between estradiol 16α-hydroxylation and human papillomavirus infection in cervical cell transformation

Salazar

Mercado

Sojo

et al. 2001

Gynecological Endocrinology

View full text Add to dashboard Cite

show abstract

Soy Isoflavones—Phytoestrogens and What Else?

Barnes

2004

The Journal of Nutrition

View full text Add to dashboard Cite

The weak estrogen-like properties of isoflavonoids were discovered over 50 y ago. In recent years, the overall effects of the isoflavones in soy on human health have been the subject of lively debate largely based on their presumed estrogenic properties. Missing from our knowledge base is the systematic identification of the cellular and biochemical targets of isoflavones and the mechanisms that they influence. Because of the benign effects of isoflavones on cellular integrity, a concentration of the isoflavones can be reached in cell culture models where almost any process can be modulated. Modern systems biology approaches and high dimensional analysis techniques offer new ways to better understand the function of how cells and integrated biological mechanisms respond to compounds such as isoflavones. Data from experiments using DNA microarray analysis for examining the effects of genistein in the developing rat uterus indicate that genistein alters the expression of 6-8 times as many genes as does a physiological estrogen such as 17 beta-estradiol. Although these new approaches are exciting, their incipient high dimensionality places considerable strain on the quality of experimental design and meaningful statistical interpretation of the resulting data. In another approach using affinity chromatography methods, DING, a novel genistein-binding protein of yet unknown function, was isolated from human breast cancer MCF-7 cells. Its function remains to be established.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Hyperplastic Changes and Receptor Status in the Breast Tissue of Bodybuilders Under Anabolic?androgenic Steroid Stimulation

Cited by 3 publications

References 12 publications

Relationship between estradiol 16α-hydroxylation and human papillomavirus infection in cervical cell transformation

Relationship between estradiol 16α-hydroxylation and human papillomavirus infection in cervical cell transformation

Relationship between estradiol 16α-hydroxylation and human papillomavirus infection in cervical cell transformation

Soy Isoflavones—Phytoestrogens and What Else?

Contact Info

Product

Resources

About