Hyperpolarized Metabolic and Parametric CMR Imaging of Longitudinal Metabolic-Structural Changes in Experimental Chronic Infarction

MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review

“…Currently, hyperpolarized cardiac magnetic resonance imaging (CMR) can provide additional information that current myocardial viability assessments are unable to provide [13]. Indeed, CMR hyperpolarized 13 C-pyruvate could potentially give additional information compared to conventional CMR and/or cardiac positron emission tomography (PET) due to the added metabolic measurements available [10,14]. The current results suggest that hyperpolarized CMR holds great potential, so much so that clinical adoption is starting to be proposed [15].…”

Considerations for hyperpolarized 13C MR at reduced field: Comparing 1.5T versus 3T

“…Metabolic images were obtained using echo shift encoding over two consecutive heartbeats with six echo‐shifted images (12.3 / 11.6 ms echo time and 2.3 / 1.15 ms echo spacing at 1.5T / 3T) acquired with a spectrally selective binomial 1‐2‐1 excitation pulse (30$$$ {}^{\circ } $$$ flip angle, 20 ppm excitation bandwidth), interleaved by a pyruvate shot acquired with a sinc pulse (5$$$ {}^{\circ } $$$ flip angle, 0.75 ms duration) 10,30 . Reconstruction was performed in MATLAB using nonlinear conjugate gradient‐based reconstruction with ground truth B$$$ {}_0 $$$ correction based on a measured $$$ {}^1 $$$H field map, and total variation regularization with $$$ \lambda =0.3 $$$ 10 .…”

“…Metabolic images were obtained using echo shift encoding over two consecutive heartbeats with six echo-shifted images (12.3 / 11.6 ms echo time and 2.3 / 1.15 ms echo spacing at 1.5T / 3T) acquired with a spectrally selective binomial 1-2-1 excitation pulse (30 • flip angle, 20 ppm excitation bandwidth), interleaved by a pyruvate shot acquired with a sinc pulse (5 • flip angle, 0.75 ms duration). 10,30 Reconstruction was performed in MATLAB using nonlinear conjugate gradient-based reconstruction with ground truth B 0 correction based on a measured 1 H field map, and total variation regularization with 𝜆 = 0.3. 10 Image SNR was calculated as the magnitude of the metabolite (m) image 𝝆 m over pixels v of each dynamic frame t d divided by the SD over all pixels from the last dynamic frame t noise (noise only) of the reconstruction without regularization ρm .…”

New Horizons in Hyperpolarized 13C MRI

“…Hyperpolarized perfusion imaging has the potential to provide as accurate perfusion information as 15 O-water PET, and it has been demonstrated that rest/stress pyruvate imaging is possible [ 83 ]. The current evidence suggests that hyperpolarized CMR holds great potential and that the method is ready for clinical adoption [ 84 – 89 ].…”