Hypersecretion of luteinising hormone: a significant cause of infertility and miscarriage

Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

“…It was postulated that oocytes retrieved from patients with PCOS are often immature and of poorer quality with lower fertilization capacity [34,35], although it has been disputed in our previous comparison [36]. In current study we have also demonstrated that the mature oocytes dominated in retrieved cohort of oocytes with no significant differences between both studied protocols.…”

The significance of high follicular-phase luteinizing hormone levels in the treatment of women with polycystic ovarian syndrome by in vitro fertilization

“…An inverse correlation between the LH:FSH ratio and mature oocytes in PCOS patients stimulated for IVF with HMG, or with GnRH-a plus HMG, was reported (4). Moreover, a reliable marker of oocyte quality is their fertilization rate, and several investigators (3,14,15) have reported that increased LH levels significantly reduced the fertilization and cleavage rates. The administration of GnRH-a seems to have a beneficial effect on oocyte quality by reversing, at least partly, the adverse effect of raised serum LH levels in PCOS patients (4).…”

“…This inappropriate secretion of LH seems to affect both fertility and pregnancy outcomes of PCOS women attempting either natural conception or conception after medical ovulation induction (1,3).…”

“…Jan response to stimulation and the ART results (1,3,4). Qn the other hand, the use of gonadotropinreleasing hormone analogues (GnRH-a) in the long desensitization protocol suppresses endogenous LH production and prevents premature LH surges, exerting a beneficial effect on ART results (1,(4)(5)(6).…”

Infertility Treatment in Patients with Polycystic Ovary Syndrome (PCOS)

“…Metabolic disorders such as elevated levels of LH [9], prolactin [10], insulin and androgens are common and can have long-term health consequences of PCOS women. LH hypersecretion is associated with menstrual disorders and subsequent infertility.…”