Hypersensitivitätssyndrom unter Therapie mit Allopurinol bei asymptomatischer Hyperurikämie mit tödlichem Ausgang

Hammer, B; Link, Ann Marie; Wagner, Annette D.; Bohm, Matt

doi:10.1055/s-2001-18563

Cited by 28 publications

(8 citation statements)

References 17 publications

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“…However, its usage is limited by hypersensitivity problems (Hammer et al. 2001 ), Stevens–Johnson syndrome (Fritsch and Sidoroff 2000 ), renal toxicity (Horiuchi et al. 2000 ) and even fatal liver necrosis (Pereira et al.…”

Section: Introductionmentioning

confidence: 99%

Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice

Zhu

Tai

Wan

et al. 2017

Pharmaceutical Biology

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Context: Tea (Camellia sinensis (L.) Kuntze [Theaceae]) is used to induce urination and inducing nervous excitation. Green and black teas have multifarious physiological functions. The different effects of green and black tea aqueous extracts (GTEs and BTEs) on hyperuricemia are not definitely reported. Objective: The different effects of GTEs and BTEs on lowering serum uric acid (UA) in hyperuricemic mice were determined. Materials and methods: Kunming mice were divided into nine groups (n = 6/each group). GTEs and BTEs at the doses of 0.5, 1 and 2 g/kg were orally administrated to mice for seven days, respectively. Hepatic xanthine oxidase (XOD) and adenosine deaminase (ADA) activities as mechanisms of actions were assessed. Results: Research indicated that the LD50 of tea extract is greater than 2 g/kg in mice. UA levels were suppressed significantly with dose-dependent treatment of 0.5, 1 and 2 g/kg BTEs (up to 25.5%, 28.7% and 29.8%, respectively); the serum UA levels were decreased by GTEs but not significant. The activities of XOD and ADA in high dose (2 g/kg) groups of both GTEs and BTEs were notably lower than those of the model group. Discussion and conclusions: The results suggested that both GTEs and BTEs have hypouricaemic and renal protective effects on hyperuricemic mice and the latter one was better. Our study sheds light on the research and development of anti-hyperuricemic functional foods and drugs from tea.

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Section: Introductionmentioning

confidence: 99%

Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice

Zhu

Tai

Wan

et al. 2017

Pharmaceutical Biology

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“…Allopurinol is a potent XO inhibitor with a purine backbone and has been used clinically for more than 40 years (Murata et al 2009 ). Unfortunately, this drug has infrequent and severe side effects as in the cause of hypersensitivity syndrome (Hammer et al 2001 ), Stevens–Johnson syndrome (Fritsch and Sidoroff 2000 ), and renal toxicity (Horiuchi et al 2000 ). Therefore, there is a need to develop other novel chemical structural types of XO inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

et al. 2016

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BackgroundBased on some previous research, the chalcone derivatives exhibited potent xanthine oxidase inhibitory activity, e.g. sappanchalcone (7), with IC50 value of 3.9 μM, was isolated from Caesalpinia sappan. Therefore, objectives of this research are design and synthesis of 7 and other chalcone derivatives by Claisen–Schmidt condensation and then evaluate their XO inhibitory activity.ResultsFifteen chalcone derivatives were synthesized by Claisen–Schmidt condensation, and were evaluated for XO inhibitory activity. Nine out of 15 synthetic chalcones showed inhibitory activity (3; 5–8; 10–13). Sappanchalcone derivatives (11) (IC50, 2.5 μM) and a novel chalcone (13) (IC50, 2.4 μM) displayed strong xanthine oxidase inhibitory activity that is comparable to allopurinol (IC50, 2.5 μM). The structure–activity relationship of these chalcone derivatives was also presented.ConclusionsIt is the first research on synthesis sappanchalcone (7) by Claisen–Schmidt condensation. The overall yield of this procedure was 6.6 %, higher than that of reported procedure (4 %). Design, synthesis, and evaluation of chalcone derivatives were carried out. This result suggests that the chalcone derivative can be used as potential non-purine XO inhibitors.Graphical abstractThe chalcone derivatives as potential non-purine xanthine oxidase inhibitors Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-016-3485-6) contains supplementary material, which is available to authorized users.

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“…Some hypouricemic agents, including uricosuric agents and xanthine oxidase inhibitors, are available [3]; however, adverse effects such as gastrointestinal irritation, bone marrow suppression, renal toxicity and hypersensitivity syndromes always limit their clinical uses [4,5]. Therefore, it is very important to search for better hypouricemic medicines.…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effect of Rutin on Oxonate-Induced Hyperuricemia and Renal Dysfunction in Mice

Chen¹,

Hu²,

Zhang³

et al. 2013

Pharmacology

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Aims: The aim of the present study was to investigate the effects of rutin on potassium oxonate-induced hyperuricemia and renal dysfunction in mice. Methods: Rutin was administered orally 1 h after oxonate at doses of 25, 50 and 100 mg·kg^-1. Serum uric acid levels and kidney function parameters were assayed. Mouse uromodulin levels in serum, urine and kidney were determined by the ELISA method. Simultaneously, the expression levels of renal organic ion transporters were detected. Results: Rutin significantly decreased serum urate, creatinine and blood urea nitrogen, serum and kidney uromodulin levels, and increased urine uromodulin, urate and creatinine excretion in hyperuricemic mice. Rutin at 50 and 100 mg·kg^-1 significantly downregulated mRNA and protein levels of mouse glucose transporter 9 and urate transporter 1, and upregulated mRNA and protein levels of organic anion transporter 1 and organic cation/carnitine transporters in the kidney of hyperuricemic mice. Conclusions: Rutin exerted its hypouricemic action and renal function improvement by the regulation of renal organic ion transporters.

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Hypersensitivitätssyndrom unter Therapie mit Allopurinol bei asymptomatischer Hyperurikämie mit tödlichem Ausgang

Cited by 28 publications

References 17 publications

Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice

Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice

Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

Beneficial Effect of Rutin on Oxonate-Induced Hyperuricemia and Renal Dysfunction in Mice

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