Hypersplenism Associated With Late-Presenting Congenital Diaphragmatic Hernia

Lu, Xin; Shen, Zhen; Dong, Kuiran; Zheng, Shan

doi:10.1097/md.0000000000003707

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…This is uncommon but sometimes necessary. Others did not demonstrate evidence of splenic dysfunction on blood smears, but this may be insensitive for transient splenic dysfunction, which has been reported in CDH patients [7,8]. Although conservative antimicrobial management is typically practiced in CDH patients, long term data regarding encapsulated organism infections in CDH patients are limited [9].…”

Section: Discussion/conclusionmentioning

confidence: 99%

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High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients

Gu,

Devine,

Hedrick

et al. 2024

Preprint

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Pediatric extreme thrombocytosis (EXT, platelet count > 1000 x 103/µL) is rare. In a single center retrospective analysis of hospitalized children with EXT, infants with congenital diaphragmatic hernia (CDH) were overrepresented. In general pediatric patients, EXT is usually secondary to infection or inflammation, but most of the 14 CDH patients with EXT had no identifiable inciting factor. Instead, there was evidence that splenic dysfunction and bone marrow hyperactivity underlied EXT in CDH patients. None were associated with bleeding or thrombosis. Our findings identify mechanisms underlying EXT, and aid clinical interpretation and management of EXT in the pediatric population.

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Section: Discussion/conclusionmentioning

confidence: 99%

“…Other CDH patients with EXT did not have evidence of splenic dysfunction on blood smears at any time. However, these indicators may be insensitive to transient splenic dysfunction, which can occur in CDH patients [7,8].…”

Section: Bone Marrow Hyperactivity and Splenic Dysfunction In Cdh Pat...mentioning

confidence: 99%

High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients

Gu,

Devine,

Hedrick

et al. 2024

Preprint

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“…Common anomalies include: cardiovascular abnormalities, particularly atrial septal defects and tetralogy of Fallot, genetic syndrome (especially Down syndrome), malrotation and chest wall deformities [ 4 ]. In the pediatric age group, MH is rare, accounting for about 1-5% of all types of congenital diaphragmatic hernia [ 2 , 4 , 5 ]. Despite the potential for associated anomalies, children with MH often exhibit milder symptoms, leading to delayed diagnosis [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some symptoms include dyspnea, especially during physical activity, chest pain, recurrent infections in the respiratory tract, or gastrointestinal issues such as nausea or abdominal pain. It is noteworthy that none of the symptoms seen in older infants with MH may be specifically linked to this defect, in contrast to newborn posterolateral hernias, which usually result in respiratory distress directly after birth [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Foreign Body Ingestion Ending Up in Late-Presenting Morgagni Hernia Diagnosis: A Case Report

Kanna,

Lamprinou,

Skondras

et al. 2024

Cureus

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Morgagni hernia (MH), also known as a retrosternal or parasternal hernia, is a rare type of congenital diaphragmatic hernia (CDH) characterized by a defect in the anterior diaphragm. Patients with late-diagnosed MH typically present with vague gastrointestinal or respiratory symptoms. In some instances, MH is incidentally identified through chest X-rays performed for other reasons, such as foreign body ingestion, as illustrated in our presented case. We present a case of a delayed congenital diaphragmatic hernia of the Morgagni type in a two-year-old boy with a history of foreign body ingestion and severe abdominal pain. Diagnostic imaging, including chest radiograph and computed tomography (CT) scan, confirmed the diaphragmatic defect. Surgical repair, performed laparoscopically, resulted in an uncomplicated postoperative course and a favorable long-term outcome.

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“…Geç KDH sıklığı çeşitli çalışmalarda %5-25 arasında bildirilmiştir. 5 Seksen beş KDH olgusunun değerlendirildiği bir çalışmada olguların %20'si geç tanı almış ve grupta gastrointestinal semptomlar ön planda iken hastaların %18'inde herhangi bir şikayet saptanmamıştır. Bu çalışmada hastalar geç tanı almalarına rağmen prognozun iyi olduğu ve en sık eşlik eden anomalinin konjenital kalp hastalığı olduğu fakat bunun mortaliteyi artırmadığı bildirilmiştir.…”

Section: Discussionunclassified