Hypertension and Dyslipidemia in Patients with Pre-Diabetes

Tsimihodimos, Vasilis; Florentin, Matilda

doi:10.1016/b978-0-12-800093-9.00013-2

Cited by 2 publications

(1 citation statement)

References 191 publications

(159 reference statements)

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“…[27][28][29] On the other hand, emerging evidence has suggested that prediabetes is potentially linked to an adverse lipid profile. 30 For instance, it has been demonstrated that HbA1c-defined prediabetes is associated with abnormal lipid profiles (characterized by high TG levels and low HDL-C levels) among adults. 31 However, the results of this analysis can be highly confounded due to the fact that the authors did not account for participants' body fat mass.…”

Section: Discussionmentioning

confidence: 99%

Obesity and Prediabetes are Jointly Associated with Lipid Abnormalities Among Adolescents: A Cross-Sectional Study

Almari¹,

Mohammad²,

Abubaker³

et al. 2021

DMSO

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Obesity and prediabetes are common among adolescents; however, it is unclear whether they jointly influence lipid levels. Hence, this study sought to assess whether obesity and prediabetes independently or jointly influence lipid levels among adolescents. Methods: A cross-sectional study enrolled school students aged 14-19 years (n = 1584). Body mass index (BMI)-for-age z-scores were estimated, and glycated hemoglobin A1c (HbA1c) and lipid profile were measured in capillary blood. Prediabetes was defined as 5.7≤ HbA1c% ≤6.4. Geometric means of lipids were calculated, and linear regression was used to estimate the ratio of geometric means (RoGM) and their 95% confidence intervals (CI). All analyses were stratified by sex. Results: Of the total study participants, 52.1% (826/1584) were females and the majority were aged between 14.0 (5th percentile) and 18.0 (95th percentile) years. Based on BMI-forage categories, 356 (22.5%) and 494 (31.2%) participants were classified as overweight and obese, respectively. Moreover, 34.3% (543/1584) of the study participants met the prediabetes definition. Compared to those with normal BMI and no prediabetes (reference category), participants classified as obese and having prediabetes had elevated levels of total cholesterol (TC; RoGM=1.09, 95% CI: 1.06-1.13), low-density lipoprotein cholesterol (LDL-C; 1.21, 1.13-1.29), non-high-density lipoprotein cholesterol (non-HDL-C; 1.20, 1.14-1.26), and triglycerides (TG; 1.18, 1.09-1.27) and reduced HDL-C (0.91, 0.88-0.95) levels. Independent of prediabetes, obesity was associated with all the investigated lipids. Prediabetes alone was associated with reduced levels of LDL-C and increased levels of HDL-C only among females. Conclusion: Obesity independently and in combination with prediabetes demonstrated unfavorable effects on lipids among male and female adolescents, whereas prediabetes independently influenced LDL-C and HDL-C favorably only among females.

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