Hypertension and Electrolyte Disorders in Patients with COVID-19

Lim, Jeong-Hoon; Jung, Hee-Yeon; Choi, Ji-Young; Park, Sun-Hee; Kim, Chan‐Duck; Kim, Yong-Lim; Cho, Jang‐Hee

doi:10.5049/ebp.2020.18.2.23

Cited by 19 publications

(20 citation statements)

References 71 publications

(80 reference statements)

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“…Unfortunetely we could'nt calculate this part of water loss when we plan our treatment. The high incidence of tachypnea in hypernatremic patients may be another reason for the cause of dysnatremia (16) . More studies are needed to explain this mechanism and findings.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Dysnatremia in COVID-19 Disease

Ömeroğlu¹,

Öztop²

2021

Terh

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Objective: The infection of Corona 2019 (COVID-19) had first diagnosed in December 2019 and evolved into a worldwide pandemic in March 2020. In Turkey first diagnose was announced in March 2020. Low costed and easily accessible laboratory parameters needed for predicting the prognosis of this disease as its outcome pattern vary greatly from patient to patient. There is promising data on predicting the outcomes with disnatremic results. Methods: In this study we retrospectively investigated all adults with the diagnosis of COVID-19 who attended to Turkan Ozilhan Hospital over a 3 months period. We evaluated the relation of dysnatremia (hyponatremia as <135 mmol/L or hypernatremia as >145 mmol/L) for need of intensive care unit (ICU) treatment, need of intubation for mechanic ventilatory support and inpatient mortality. Results: one thousand seventy tree patients with COVID-19 [53..9% males (793 patients) and 46.1% females (680 patients), were investigated for this study. Their median age was 53.9 years ranging betweent 19-94. The dysnatremic groups had significantly higher rates of need for ICU and intubation The need for ICU was 89 (21.5%) patients in normonatremic group but 38 (76%) patients in hypernatremic and 71 (64%) in hyponatremic patients (p<0.01 for each of them). The mortality rate was 5% in normonatremic patients but 50% in hypernatremic and 28% in hyponatremic patients (p<0.01 for each of them). Conclusion: In this study we aimed to draw attention to the importance of abnormal sodium levels as a predictive marker in COVID-19. In small town hospitals the physicians should be aware of the risks of disnatremic patients with COVID-19 and take precautions while treating them.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Dysnatremia in COVID-19 Disease

Ömeroğlu¹,

Öztop²

2021

Terh

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“…It has been recognized that the severity of COVID-19 is higher in patients with diabetes mellitus (DM) and hypertension (16) Moreover, COVID-19 might increase the risk of hyperglycemia, which can modulate immune and inflammatory responses, thus worsening the risk of severe disease (17). Complicating the picture even more, many medications used for COVID-19 treatment can affect glucose metabolism, particularly with preexisting DM; thus, both glucose monitoring and individualized management are usually needed for patients with DM and/or hypertension (16). Patients with cardiovascular or kidney disease have been also shown to have a poorer prognosis than those without these diseases and COVID-19 (18,19).…”

Section: Cushing's Disease (Cd)mentioning

confidence: 99%

Pituitary Disorders and COVID-19, Reimagining Care: The Pandemic A Year and Counting

Fleseriu

2021

Front. Endocrinol.

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“…When it was discovered that ACE2 served as the primary cellular entry point for SARS-CoV2, researchers rushed to determine the implications for patients with hypertension and particularly those who routinely take ACE inhibitors (ACEi) and angiotensin receptor blockers (ARBs). There remain mixed results with some studies suggesting a protective effect for those taking ACEi/ARBs as they may competitively inhibit the receptors, while others showing a deleterious effect from higher rates of AKI and admissions to critical care units and electrolyte derangements [ 66 , 67 ]. A meta-analysis among adult patients with hypertension and COVID-19 revealed lower mortality among those who were on ACEi/ARBs compared to those not on the medications [ 68 ].…”

Section: Sars-cov2 Infection In Special Pediatric Nephrology Populationsmentioning

confidence: 99%

Kidney implications of SARS-CoV2 infection in children

et al. 2021

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Research indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection can impact every organ, and the effects can range from asymptomatic to severe disease. Since it was first discovered in December 2019, our understanding has grown about its impact on kidney disease. In general, children have less severe disease than adults, and this tendency appears to extend to special pediatric kidney populations (e.g., chronic kidney disease and immunosuppressed patients with solid organ transplants or nephrotic syndrome). However, in a fraction of infected children, SARS-CoV2 causes an array of kidney manifestations, ranging from acute kidney injury to thrombotic microangiopathy, with potential implications for increased risk of morbidity and mortality. Additional considerations surround the propensity for clotting extracorporeal circuits in children with SARS-CoV2 infection that are receiving kidney replacement therapy. This review provides an update on our current understanding of SARS-CoV2 for pediatric nephrologists and highlights knowledge gaps to be addressed by future research during this ongoing pandemic, particularly the social disparities magnified during this period.

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Hypertension and Electrolyte Disorders in Patients with COVID-19

Cited by 19 publications

References 71 publications

Prognostic Value of Dysnatremia in COVID-19 Disease

Prognostic Value of Dysnatremia in COVID-19 Disease

Pituitary Disorders and COVID-19, Reimagining Care: The Pandemic A Year and Counting

Kidney implications of SARS-CoV2 infection in children

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