Hypertension and fatty liver: guilty by association?

Brookes, Matthew; Cooper, Barrett R.

doi:10.1038/sj.jhh.1002148

Cited by 44 publications

(56 citation statements)

References 89 publications

(91 reference statements)

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“…ICV administration of TUDCA over 3 days lowered arterial pressure and heart rate in DIO mice, a response that was evident within 24-48 hours, with blood pressure and heart rate in ICV TUDCA-treated DIO mice returning to normal chow levels within 72 hours ( Figure 2, H and I). Thus, brain ER stress contributes to obesity-induced hypertension, an abnormality that commonly occurs in concert with NAFLD (27,28).…”

Section: Resultsmentioning

confidence: 99%

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Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain

et al. 2017

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Section: Resultsmentioning

confidence: 99%

“…In addition to contributing to NAFLD, obesity is also associated with an increased risk for the development of cardiovascular diseases, including hypertension (27,28). Emerging evidence also indicates that nonobese hypertensive patients are prone to the development of NAFLD (46).…”

Section: Discussionmentioning

confidence: 99%

Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain

et al. 2017

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“…11,[17][18][19] Risk factors for macrovesicular steatosis include alcoholism, diabetes mellitus, hypertension, obesity, various drugs (such as amiodarone and methotrexate), cellular toxins, malnutrition, and anoxia. [20][21][22][23][24] The posttransplant effects of steatosis are not completely understood but are thought to be associated with greater susceptibility to ischemia. 25 Buildup of fat deposits in the hepatocytes results in an increased cell volume, which may cause sinusoidal obstruction and is more frequently found in the elderly.…”

Section: Macrovesicular Steatosismentioning

confidence: 99%

Approach to Intraoperative Consultation for Donor Liver Biopsies

Melin

Miick

Young

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.— As demand for organs to treat end-stage liver disease increases, donor livers once deemed only marginally suitable for donation are being considered for transplantation. Pathologists are increasingly being asked to evaluate these livers for acceptability. This article provides guidelines for frozen section evaluation of livers for transplantation. Objective.— This article concentrates on the histopathologic features of transplant suitability with appropriate clinicopathologic correlation for the practicing pathologist. Recommendations for proper handling and sampling of tissue are discussed. Relative and absolute contraindications as well as artifacts and benign conditions are emphasized. Data Sources.— Sources include a compilation of the authors' experiences in academic and community liver transplantation centers. In addition, relevant medical literature was reviewed, as well as Web sites specializing in organ transplantation, such as Transplant Pathology Internet Services and the Organ Procurement and Transplantation Network. Conclusions.— Malignancy and extensive necrosis in the liver are absolute contraindications to transplantation. Evaluation of macrosteatosis, fibrosis, hepatitis, and necrosis depends on the severity of disease and correlation with the clinical situation. Donor age of greater than 60 years does not preclude transplantation. Artifacts and benign conditions need to be understood to prevent wastage of precious organs and to ensure that an appropriate organ is provided for the recipient.

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“…Teori "multiple hit" merupakan teori yang paling banyak diterima untuk menjelaskan patogenesis perlemakan hati nonalkoholik dan progresivitasnya dari simple steatosis menjadi non-alcoholic steatohepatitis (NASH). 2,11,12 Peningkatan aktivitas sistem renin, angiotensin, dan juga aldosteron pada hipertensi yang menginduksi resistensi insulin dianggap memiliki peranan penting dalam perkembangan perlemakan hati nonalkoholik. 2,13 USG merupakan pemeriksaan tidak invasif, tanpa radiasi dengan ketersediaan yang luas dan biaya terjangkau serta memiliki sensitivitas dan spesifisitas yang cukup tinggi dalam mendiagnosis perlemakan hati nonalkoholik.…”

Section: Pendahuluanunclassified

Hubungan Stadium Hipertensi dengan Derajat Perlemakan Menggunakan Indeks Hepatorenal Sonografi

Marina

Nugraha

Santiana

et al. 2017

GMHC

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AbstrakHipertensi merupakan prekursor perkembangan perlemakan hati nonalkoholik. Modalitas pencitraan USG paling banyak digunakan untuk menegakkan diagnosis perlemakan hati nonalkoholik. Saat ini dikembangkan teknik USG menggunakan parameter indeks hepatorenal sonografi yang dihitung dengan program software ImageJ dan digunakan untuk memprediksi derajat perlemakan hati. Penelitian ini bertujuan mengetahui hubungan antara stadium hipertensi dan derajat perlemakan hati nonalkoholik menggunakan indeks hepatorenal sonografi. Penelitian menggunakan studi observasional analitik dengan rancangan cross sectional, pengambilan sampel dilakukan secara consecutive admission. Penelitian dilaksanakan di Bagian Radiologi RSUP Dr. Hasan Sadikin Bandung periode Juni-Agustus 2016. Subjek penelitian 50 orang, laki-laki 22 orang, perempuan 28 orang, usia termuda 25 tahun, dan tertua 77 tahun. Hasil penelitian melalui uji statistik chi-square menunjukkan derajat perlemakan hati nonalkoholik ringan lebih banyak pada prehipertensi (9 dari 16), derajat sedang pada hipertensi stadium I (10 dari 19), dan derajat berat pada hipertensi stadium II (8 dari 15) dengan p<0,001. Perlemakan hati nonalkoholik derajat sedang dan berat lebih sering ditemukan pada perempuan dengan hipertensi (p=0,005) Simpulan, terdapat hubungan antara stadium hipertensi dan derajat perlemakan hati nonalkoholik menggunakan indeks hepatorenal sonografi. Kata kunci: ImageJ, indeks hepatorenal sonografi, perlemakan hati nonalkoholik, stadium hipertensi, USG The Association of Hypertension Stage and Non-Alcoholic Fatty Liver Degree Using Hepatorenal Sonography Index AbstractHypertension is considered as a precursor to the development of non-alcoholic fatty liver disease (NAFLD). Ultrasonography techniques have been developed using sonography hepatorenal index parameter calculated by ImageJ, that can predict the degree of NAFLD. This study aim to determine the relationship between hypertension stage and the degree of NAFLD using sonography hepatorenal index. The research is an observational using cross sectional methods, with consecutive admission sampling method. The study was performed at Dr. Hasan Sadikin Hospital Bandung from June to August 2016. A total of 50 subjects, 22 men and 28 women, with the youngest 25 and the oldest 77 years old participated. Results indicated that the mild degree of NAFLD were higher on prehypertension (9 of 16), the moderate degree on stage I hypertension (10 of 19), while the severe degree found on stage II hypertension (8 of 15), with p<0.001. Moderate and severe degree of NAFLD in hypertensive patient was more common in women (p=0.005). In conclusion, there is a relationship between hypertension stage and the degree of NAFLD.

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Hypertension and fatty liver: guilty by association?

Cited by 44 publications

References 89 publications

Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain

Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain

Approach to Intraoperative Consultation for Donor Liver Biopsies

Hubungan Stadium Hipertensi dengan Derajat Perlemakan Menggunakan Indeks Hepatorenal Sonografi

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