“…Chronic inhibition of NOS by L-NAME has also been reported to induce sustained hypertension in rats (Ribeiro et al, 1992;Bryant et al, 1995;Küng et al, 1995;Dowell et al, 1996;Takase et al, 1996;Henrion et al, 1997;Ledingham and Laverty, 1997;Moreau et al, 1998;Zhao et al, 1999;Sekiguchi et al, 2001). It has also been reported that endotheliumdependent relaxation (EDR) (Bryant et al, 1995;Küng et al, 1995;Takase et al, 1996;Zhao et al, 1999;Sekiguchi et al, 2001) and cyclic GMP production (Arnal et al, 1992) were decreased by this treatment, indicating some impairment of EDNO production.…”