Hypertension on admission is associated with a lower risk of early seizures after stroke

Hundozi, Zylfije; Shala, Argjend; Boshnjaku, Dren; Bytyqi, Samir I; Rrustemi, Jehona; Rama, Muhamed; Jashari, Fisnik

doi:10.1016/j.seizure.2016.01.016

Cited by 13 publications

(22 citation statements)

References 29 publications

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“…It is well established that hypertension is a major risk factor for ICH; unexpectedly, however, the present study revealed that hypertension was associated with a lower risk of PSE in the multivariable analysis after adjusting for antihypertensive medication use. A prior study by Hundozi et al had similar findings [38]. In their study, patients with hypertension when admitted for stroke had a lower risk of poststroke seizure.…”

Section: Discussionsupporting

confidence: 64%

“…A prior study by Hundozi et al . had similar findings . In their study, patients with hypertension when admitted for stroke had a lower risk of poststroke seizure.…”

Section: Discussionmentioning

confidence: 99%

“…In their study, patients with hypertension when admitted for stroke had a lower risk of poststroke seizure. Although no definite pathophysiological mechanism could explain the results , we propose several possibilities herein. First, brain haemorrhages are often associated with uncontrolled high blood pressure , but patients might not be diagnosed with hypertension before stroke because of unawareness of their elevated blood pressure.…”

Section: Discussionmentioning

confidence: 99%

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Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population‐based cohort study

Lin

2018

Brit J Clinical Pharma

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Section: Discussionsupporting

confidence: 64%

“…A prior study by Hundozi et al . had similar findings . In their study, patients with hypertension when admitted for stroke had a lower risk of poststroke seizure.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population‐based cohort study

Lin

2018

Brit J Clinical Pharma

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“…Metabolic disturbances such as elevated blood glucose or low sodium levels can also precipitate seizures 22 , 30 , 42 , 48 . Low blood pressure and normal lipid levels seem to have protective effect 29 , 44 , 53 . The other risk factors were low ASPECTS score, alcoholism, previous stroke, male gender, and impaired consciousness 28 , 31 , 36 , 45 , 54 (Table 2).…”

Section: Ess After Strokementioning

confidence: 99%

Early seizures after ischemic stroke: focus on thrombolysis

et al. 2019

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Introduction.Stroke is a significant underlying cause of epilepsy. Seizures due to ischemic stroke (IS) are generally categorized into early seizures (ESs) and late seizures (LSs). Seizures in thrombolysis situations may raise the possibility of other etiology than IS.Aim.We overtook a systematic review focusing on the pathogenesis, prevalence, risk factors, detection, management, and clinical outcome of ESs in IS and in stroke/thrombolysis situations. We also collected articles focusing on the association of recombinant tissue-type plasminogen activator (rt-PA) treatment and epileptic seizures.Results.We have identified 37 studies with 36,775 participants. ES rate was 3.8% overall in patients with IS with geographical differences. Cortical involvement, severe stroke, hemorrhagic transformation, age (<65 years), large lesion, and atrial fibrillation were the most important risk factors. Sixty-one percent of ESs were partial and 39% were general. Status epilepticus (SE) occurred in 16.3%. 73.6% had an onset within 24 h and 40% may present at the onset of stroke syndrome. Based on EEG findings seizure-like activity could be detected only in approximately 18% of ES patients. MRI diffusion-weighted imaging and multimodal brain imaging may help in the differentiation of ischemia vs. seizure. There are no specific recommendations with regard to the treatment of ES.Conclusion.ESs are rare complications of acute stroke with substantial burden. A significant proportion can be presented at the onset of stroke requiring an extensive diagnostic workup.

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“…[13,15] There are controversial data on the frequency of seizures after CVST; a prevalence of 10% to 50% has been reported. [16] Most of the seizure types are focal seizures. Rarely, lifethreatening generalized tonic clonic-seizures can be seen.…”

Section: Discussionmentioning

confidence: 99%

Superior Sagittal Sinus Thrombosis Presenting with Hallucinations in the Puerperium: A Case Report

Hundozi¹,

Ibishi²,

Jashari³

et al. 2016

Int J Biomed

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Cerebral venous sinus thrombosis is an uncommon cause of stroke presenting with varied presentation patterns. We report a case of a 21-year-old woman with superior sagittal sinus (SSS) thrombosis (SSST) developing after childbirth, presenting with visual hallucinations, severe headache, and tonic-clonic seizures. Time-of-flight magnetic resonance angiography (TOF-MRA) demonstrated the presence of thrombus in SSS. She was treated with low molecular weight heparin (LMWH) followed by warfarin. She had excellent recovery a few weeks after admission and was regularly followed up. Although this condition can be presented with different neurological symptoms, it does not typically present with hallucinations. We suggest that CSVT should be suspected even when a patient presents with an atypical picture in a category of patients at higher risk. (Int J Biomed. 2016; 6(4):294-297.)

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Hypertension on admission is associated with a lower risk of early seizures after stroke

Abstract: ES after stroke was equally frequent in patients with ischemic and haemorrhagic stroke. Low/normal blood pressure on admission and younger patient age were risk factors for ES after stroke.

Cited by 13 publications

References 29 publications

Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population‐based cohort study

Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population‐based cohort study

Early seizures after ischemic stroke: focus on thrombolysis

Superior Sagittal Sinus Thrombosis Presenting with Hallucinations in the Puerperium: A Case Report

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