2023
DOI: 10.1101/2023.03.14.23287281
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Hypertensive disorders of pregnancy and risk of cardiovascular disease: A Mendelian Randomisation study in the UK Biobank

Abstract: Background:Observational studies show that hypertensive disorders of pregnancy (HDPs) are related to unfavourable maternal cardiovascular disease (CVD) risk profiles later in life. We investigated whether genetic liability to pre-eclampsia/eclampsia and gestational hypertension is associated with CVD risk factors and occurrence of CVD events.<br /><br />Methods:We obtained genetic associations with HDPs from a genome-wide association study and used individual-participant-data of women and men from … Show more

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“…3,4,[8][9][10] Beyond the short-term implications of PE, there is increasing recognition of its long-term maternal associations with later-life hypertension, cardiovascular (CV) disease, and renal disease. [11][12][13][14][15] In this setting, the incidence of PE or gestational hypertension (gHTN) serves as an indicator of future CV risk, but it remains unclear whether the PE/gHTN is causal or is merely an indicator of underlying genetic predisposition to CV disease.…”
Section: Introductionmentioning
confidence: 99%
“…3,4,[8][9][10] Beyond the short-term implications of PE, there is increasing recognition of its long-term maternal associations with later-life hypertension, cardiovascular (CV) disease, and renal disease. [11][12][13][14][15] In this setting, the incidence of PE or gestational hypertension (gHTN) serves as an indicator of future CV risk, but it remains unclear whether the PE/gHTN is causal or is merely an indicator of underlying genetic predisposition to CV disease.…”
Section: Introductionmentioning
confidence: 99%