Hypertensive heart disease and myocardial fibrosis: How traditional Chinese medicine can help addressing unmet therapeutical needs

Liu, Mengnan; Long, Xingru; Xu, Jie; Chen, Mingtai; Yang, Huayi; Guo, Xin; Kang, Junli; Ouyang, Yue; Luo, Gang; Yang, Sijin; Zhou, Hua

doi:10.1016/j.phrs.2022.106515

Cited by 15 publications

(3 citation statements)

References 159 publications

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“…Moreover, TCM has a long history with the advantages of convenient carrying and taking in a high clinical utilization rate. According to the basis of the principle of TCM differentiation, the combined treatment with TCM will be beneficial for the treatment of HF and related diseases [ 213 ].…”

Section: The Representative Traditional Chinese Medicines With Anti-h...mentioning

confidence: 99%

The recent advance and prospect of natural source compounds for the treatment of heart failure

Chen,

Liu,

et al. 2024

Heliyon

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Section: The Representative Traditional Chinese Medicines With Anti-h...mentioning

confidence: 99%

The recent advance and prospect of natural source compounds for the treatment of heart failure

Chen,

Liu,

et al. 2024

Heliyon

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“…Compared with TCM, modern medicine has experienced rigorous scientific testing and regulation, but it has potential side effects and high treatment costs. In addition, TCM is effective in treating MF, but because of its unclear composition and targeting site, it is difficult to elucidate the detailed mechanisms ( Liu et al, 2022 ). Fundamental scientific studies, rigorous clinical trials, standard production regulation and quality control can promote the development and credibility of TCM worldwide.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Drugs for treating myocardial fibrosis

Ren,

Zhang,

Ling

et al. 2023

Front. Pharmacol.

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Myocardial fibrosis, which is a common pathological manifestation of many cardiovascular diseases, is characterized by excessive proliferation, collagen deposition and abnormal distribution of extracellular matrix fibroblasts. In clinical practice, modern medicines, such as diuretic and β receptor blockers, and traditional Chinese medicines, such as salvia miltiorrhiza and safflower extract, have certain therapeutic effects on myocardial fibrosis. We reviewed some representative modern medicines and traditional Chinese medicines (TCMs) and their related molecular mechanisms for the treatment of myocardial fibrosis. These drugs alleviate myocardial fibrosis by affecting related signaling pathways and inhibiting myocardial fibrosis-related protein synthesis. This review will provide more references and help for the research and treatment of myocardial fibrosis.

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“…It participates in the hydrolysis of lipid peroxide by scavenging free radicals to protect cells from lipid peroxide accumulation [16]. Prior studies [17][18][19][20] have also reported that traditional Chinese medicine has obvious advantages in the treatment of cardiovascular disease, which can improve the prognosis of patients, reduce the incidence of complications, and improve the safety of the medication. The representative compound preparation for the clinical treatment of CS in China is Shenfu injection (SFI).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Ginsenoside Rg5 on Hypoxia/Reoxygenation- Induced H9c2 Cardiomyocytes by Correcting Free Fatty Acids β- oxidation

Jiang

Fang

Zhang

et al. 2023

Preprint

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Clinically, the in-hospital mortality rate of cardiogenic shock (CS) is approximately 50%. In CS, metabolic pathways in the body undergo “embryonal transformation,” in which metabolic processes transform free fatty acids (FFAs) to glucose. Shenfu injection (SFI) treatment has exhibited a positive effect on cardiogenic shock, and ginsenoside Rg5 (G-Rg5) is the anticardiogenic shock component of SFI. In this study, we aimed to investigate the myocardial protective effect and mechanism of G-Rg5 in myocardial energy metabolism, especially from the perspective of FFA β-oxidation, one of the most crucial lipid metabolism pathways. Cardiomyocytes were exposed to hypoxia-reoxygenation (H/R) and treated with G-Rg5. MTT analysis was used to determine the viability of H9c2 cardiomyocytes under different interventions with G-Rg5. The levels of lactate dehydrogenase (LDH) and FFA were detected using ELISA, and adenosine triphosphate (ATP) was determined using high-performance liquid chromatography (HPLC). Furthermore, the expression of NR4A1 was determined by RT-qPCR, and the levels of AMPKα, p-AMPKα, and GPX4 were detected by western blotting to explore the underlying mechanism. We observed that G-Rg5-protected H9c2 cardiomyocytes exhibited better FFA β-oxidation regulation, thereby producing an increased abundance of ATP. G-Rg5 may correct FFA β-oxidation by regulating the levels of NR4A1, AMPKα, p-AMPKα, and GPX4. Therefore, G-Rg5 is a promising drug for CS treatment.

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Hypertensive heart disease and myocardial fibrosis: How traditional Chinese medicine can help addressing unmet therapeutical needs

Cited by 15 publications

References 159 publications

The recent advance and prospect of natural source compounds for the treatment of heart failure

The recent advance and prospect of natural source compounds for the treatment of heart failure

Drugs for treating myocardial fibrosis

Protective Effect of Ginsenoside Rg5 on Hypoxia/Reoxygenation- Induced H9c2 Cardiomyocytes by Correcting Free Fatty Acids β- oxidation

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