Hyperthermia-Induced Antitumor Activity of Thermosensitive Polymer Modified Temperature-Sensitive Liposomes

Han, Hee Dong; Choi, Min Soo; Hwang, Taewon; Song, Chung Kil; Seong, Hasoo; Kim, Tae Woo; Choi, Hoon; Shin, Byung Cheol

doi:10.1002/jps.20646

Cited by 54 publications

(38 citation statements)

References 23 publications

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“…Compared with intra-arterial administration, doxorubicin administered intravenously might obtain a lower drug concentration locally, which might limit its enhancing effect on RFA. Recent introduction of doxorubicin in temperature-sensitive liposome might increase regional drug concentration and enhance its anti-tumor effect when combined with RFA [23].…”

Section: Discussionmentioning

confidence: 99%

Radiofrequency ablation of small hepatocellular carcinoma with intravenous pegylated liposomal doxorubicin

et al. 2010

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Purpose Synergy between radiofrequency ablation (RFA) and chemotherapy was demonstrated for liver malignancy. We assess the efficacy of intravenous pegylated liposomal doxorubicin (PLD) for RFA in patients with small hepatocellular carcinoma (HCC). Methods This study was designed as a non-randomized control trial. Patients received either PLD (20 mg) intravenously before RFA, or standard RFA alone. Computed tomography was performed immediately and 4 weeks after RFA to obtain ablative diameter, area and volume for each tumor. The changes in ablation size were analyzed by paired images for each tumor. All patients were followed up regularly. Results A total of 24 patients with 29 HCCs, including 12 patients with 16 tumors (mean 2.2 cm ± 0.9) in the PLD and RFA group, and 12 patients with 13 tumors (2.4 cm ± 0.5) in the RFA alone group, were enrolled. The ablative diameter, area and volume significantly decreased 4 weeks after RFA. The ablative volume decrease was significantly greater for the RFA alone group than for the combination group (26.1 vs. 12.1%, p = 0.018). The 3-year cumulative tumor progression and survival rates did not differ significantly between the two groups. Conclusion Intravenous PLD before RFA reduced contraction of ablative volume and might have no impact on tumor progression and survival in patients with small HCC after RFA.

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Section: Discussionmentioning

confidence: 99%

Radiofrequency ablation of small hepatocellular carcinoma with intravenous pegylated liposomal doxorubicin

et al. 2010

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“…The chemistry of PNIPAM hydrogels is very well established especially in terms of their thermo-responsivity. [14][15][16][17][18][19][20][21][22][23][24] This concept is applied in this platform where hydrogel particles embedded in the polymer matrix undergo size transition to increase cargo efflux through the heterogeneous membrane. This thermoresponsive size transition is highlighted in Figs.…”

Section: A Individual Membrane Characterizationmentioning

confidence: 99%

“…Electronic addresses: amirzaher@alumni.ubc.ca and jurgen.kosel@kaust.edu.sa 1932-1058/2015/9(5)/054113/16/$30.00 V C 2015 AIP Publishing LLC 9, 054113-1 specific biomedical applications. 12,13 For example, poly(N-isopropylacrylamide) (PNIPAM) has been utilized as a thermosensitive polymer in drug delivery systems by grafting with other polymers or inorganic particles, [14][15][16][17] in the forms of nanoparticles, 18,19 micelles, 20 liposomes, 21,22 or core-shell structures. 23,24 The hydrogel presents different volume phases and hydrophilicity at a transition temperature, known as the lower critical solution temperature, which determines the hydrogel's swelling state by influencing the formation of H-bonds among polymer networks.…”

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confidence: 99%

Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes

Zaher

Wolf

et al. 2015

Biomicrofluidics

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Implantable drug delivery systems can provide long-term reliability, controllability, and biocompatibility, and have been used in many applications, including cancer pain and non-malignant pain treatment. However, many of the available systems are limited to zero-order, inconsistent, or single burst event drug release. To address these limitations, we demonstrate prototypes of a remotely operated drug delivery device that offers controllability of drug release profiles, using osmotic pumping as a pressure source and magnetically triggered membranes as switchable on-demand valves. The membranes are made of either ethyl cellulose, or the proposed stronger cellulose acetate polymer, mixed with thermosensitive poly(N-isopropylacrylamide) hydrogel and superparamagnetic iron oxide particles. The prototype devices' drug diffusion rates are on the order of 0.5-2 lg/h for higher release rate designs, and 12-40 ng/h for lower release rates, with maximum release ratios of 4.2 and 3.2, respectively. The devices exhibit increased drug delivery rates with higher osmotic pumping rates or with magnetically increased membrane porosity. Furthermore, by vapor deposition of a cyanoacrylate layer, a drastic reduction of the drug delivery rate from micrograms down to tens of nanograms per hour is achieved. By utilizing magnetic membranes as the valve-control mechanism, triggered remotely by means of induction heating, the demonstrated drug delivery devices benefit from having the power source external to the system, eliminating the need for a battery. These designs multiply the potential approaches towards increasing the on-demand controllability and customizability of drug delivery profiles in the expanding field of implantable drug delivery systems, with the future possibility of remotely controlling the pressure source. V C 2015 AIP Publishing LLC. [http://dx

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“…Amount of BSA on the surface of cationically charged liposomes was evaluated by Bradford assay 96-well plate [25]. Hundred microliters of BSA-coated liposomes and 100 L of Bio-Rad Protein Assay reagent (Hercules, CA, USA) were added to each well and then incubated for 10 min at 25 • C. Amount of BSA was assessed by measuring absorbance at 590 nm by using microplate reader (SpectraMax 190, Molecular Device, USA).…”

Section: Amount Of Bsa On the Surface Of Cationically Charged Liposomesmentioning

confidence: 99%

Increased stability in plasma and enhanced cellular uptake of thermally denatured albumin-coated liposomes

Jung

Kim

Jung

et al. 2010

Colloids and Surfaces B: Biointerfaces

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Hyperthermia-Induced Antitumor Activity of Thermosensitive Polymer Modified Temperature-Sensitive Liposomes

Cited by 54 publications

References 23 publications

Radiofrequency ablation of small hepatocellular carcinoma with intravenous pegylated liposomal doxorubicin

Radiofrequency ablation of small hepatocellular carcinoma with intravenous pegylated liposomal doxorubicin

Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes

Increased stability in plasma and enhanced cellular uptake of thermally denatured albumin-coated liposomes

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