Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles

Motoyama, Jun; Yamashita, Nobuhiko; Morino, Tomio; Tanaka, Masashi; Kobayashi, Takeshi; Honda, Hiroyuki

doi:10.1186/1477-044x-6-2

Cited by 32 publications

(22 citation statements)

References 25 publications

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“…17,[38][39][40] Direct intratumoral injections of MNPs followed by induction heating has shown some benefit in controlling tumor growth. 38,[41][42][43][44][45][46][47][48][49] Direct intratumoral injection was used in the first MNP hyperthermia clinical trial treating a prostate cancer using a 100 kHz machine designed for human patients, 50 and later in human glioma trials 51,52 which demonstrated safety and some benefit. Heating was obtained, but due to inhomogeneous MNP distribution, complete tumor eradication was not possible.…”

Section: Introductionmentioning

confidence: 99%

Intravenous magnetic nanoparticle cancer hyperthermia

Huang¹,

Hainfeld²

2013

IJN

105

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Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio . 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.

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Section: Introductionmentioning

confidence: 99%

Intravenous magnetic nanoparticle cancer hyperthermia

Huang¹,

Hainfeld²

2013

IJN

105

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“…To date, for example, it is still unclear how successful are the DMBA tumor induction protocols used in research in generating tumors. In a study on hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles, Motoyama et al (46) report, for example, that of 20 rats used only 4 exhibited "multiple growths of tumors at 1-3 sites in the body". This is not surprising given that as early as 1969 (47), it was pointed out that the assumption that the growth of neoplasms is independent of the initiating stimulus, once such neoplasms become fully established, is not universally valid for the induction of a wide variety of hepatomas by different doses and schedules of hepatocarcinogens (48) as well as for the induction of mammary tumors induced in rats exposed to different schedules of DMBA.…”

Section: Discussionmentioning

confidence: 99%

Effects of Rich-in-Fat Diets and Highly Selective COX-2 Inhibitors on 7,12-Dimethylbenz-(A)-Anthracene-Induced Tumor Growth

Miliaras

Anogeianaki

Meditskou

et al. 2009

Int J Immunopathol Pharmacol

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The effects of diet, of non-steroidal anti-inflammatory drugs, or oftheir combination on carcinogenesis continue to be a case for controversy. Diets that are high in fat have been linked to increased risk of various tumors. At the same time there is substantial, but not conclusive, evidence that the risk of breast and colon cancer correlates with total fat intake rather than a specific type of fat. On the other hand, non-steroidal anti-inflammatory drugs (NSAIDs) have been studied extensively because they appear to delay or inhibit the development of malignant and pre-malignant lesions. 7,12-Dimethylbenz-(a)-anthracene (DMBA) has been used for a long time to induce carcinogenesis in a number of rat animal models. The present study attempts to identify the effects on DMBA-induced tumor growth (a) of diets rich in fat and (b) of the highly selective COX-2 inhibitor Celecoxib, which has been claimed to offer substantial protection against carcinogenesis.

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“…The rats were exposed to 3 series of hyperthermia treatments for 30 min each. The treated tumours were well controlled over a 30-day observation period showing an induction of immunological antitumour activity mediated by the MCLs (Motoyama et al, 2008). The use of anti-HER2 immunoliposomes containing nanomagnetic particles (HMLs) for anti-HER2 antibody therapy and tumour-specific hyperthermia has been exploited for many researche groups.…”

Section: Magnetic Nanoparticle Induced Hyperthermiamentioning

confidence: 99%