Coating Nanomagnetic Particles for Biomedical Applications

Andrade, Ângela Leão; Ferreira, Roberta Viana; Fabris, José Domingos; Domingues, Rosana Zacarias

doi:10.5772/19519

Cited by 18 publications

(19 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They can be grouped into two broader categories depending on the methodology: in vitro and in vivo procedures. For in vitro applications, the main use is in diagnoses and separation/labelling of biomoleculessuch as protein, cell, Deoxyribonucleic Acid (DNA)/ Ribonucleic Acid (RNA), microorganism for in vivo applications can be further split into (i) therapies (drug delivery and hyperthermia) and (ii) diagnoses (Magnetic Resonance Imaging (MRI)) [5]. In the diagnostic medical field, MNPs are used as contrast agents to enhance the contrast in MRI.…”

Section: Introductionmentioning

confidence: 99%

“…Magnetic hyperthermia is a method to induce hyperthermia using MNPs. In this approach MNPs are firstly introduced into the desired tissues and then guided by an external magnetic field, an externally applied oscillating magnetic field induces the hyperthermia [5]. The application of MNPs offers the possibility of a self-limitation of the temperature enhancement by using a magnetic material with suitable Curie temperature, Such MNPs can bind to drugs, enzymes, proteins, nucleotides, or antibodies and can be directed to an organ, tissue, or tumor using an external magnetic field [6,7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic Hyperthermia using Cobalt Ferrite Nanoparticles: The Influence of Particle Size

Sha¹,

Ra²,

Aa³

et al. 2017

Int J Adv Tech

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnetic Hyperthermia using Cobalt Ferrite Nanoparticles: The Influence of Particle Size

Sha¹,

Ra²,

Aa³

et al. 2017

Int J Adv Tech

View full text Add to dashboard Cite

“…The applications for these materials are very diverse such as metal ion separations, 1 enzyme immobilization, 2 magnetic resonance imaging (MRI), 3 drug delivery and catalysis. 4 In chemistry, nanomagnetic catalysts have emerged as one of the most useful heterogeneous catalysts due to their numerous applications in organic synthesis. 5 These catalysts have been studied in various significant protocols in organic chemistry because they are robust, inexpensive and readily available.…”

Section: Introductionmentioning

confidence: 99%

A solvent-free synthesis of polyhydroquinolines via Hantzsch multicomponent condensation catalyzed by nanomagnetic-supported sulfonic acid

Otokesh¹,

Koukabi²,

Kolvari³

et al. 2015

S.Afr.j.chem

View full text Add to dashboard Cite

A simple and efficient procedure for the synthesis of polyhydroquinolines was developed, involving a one-pot four-component Hantzsch condensation of aromatic aldehydes, 1,3-cyclohexanediones, alkyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanomagnetic-supported sulfonic acid under solvent-free conditions. The method offers several advantages including high yields, short reaction times, a simple work-up procedure and catalyst reusability for several runs. Furthermore, easy isolation of the catalyst from the reaction mixture was enabled by use of an external magnet.

show abstract

“…pH, ionic strength and density of particles). The tendency of particles to agglomerate and adhere to the inner surfaces of microfluidic devices and non-specific adsorption of biomolecules are significantly limiting factors in such routine applications [4][5][6][7]. It is well known that spontaneous aggregation of particles is accompanied by loss of their superparamagnetic behaviour [7].…”

Section: Introductionmentioning

confidence: 99%

“…using polymers, surfactants or other biomolecules with a hydrophilic nature) is one of the ways to overcome these obstacles. Such commonly used polymer stabilizers as poly(ethylenglycol), poly(vinyl)alcohol and poly(lactic acid) and such carbohydrates as dextran, chitosan and starch have been successfully applied [3,4,6,7]. Another potential low-fouling modifier is hyaluronic acid (HA).…”

Section: Introductionmentioning

confidence: 99%

Magnetic microparticles post-synthetically coated by hyaluronic acid as an enhanced carrier for microfluidic bioanalysis

Holubová

Knotek

Palarčík

et al. 2014

Materials Science and Engineering: C

View full text Add to dashboard Cite

Iron oxide based particles functionalized by bioactive molecules have been utilized extensively in biotechnology and biomedicine. Despite their already proven advantages, instability under changing reaction conditions, non-specific sorption of biomolecules on the particles' surfaces, and iron oxide leakage from the naked particles can greatly limit their application. As confirmed many times, surface treatment with an appropriate stabilizer helps to minimize these disadvantages. In this work, we describe enhanced post-synthetic surface modification of superparamagnetic microparticles varying in materials and size using hyaluronic acid (HA) in various chain lengths. Scanning electron microscopy, atomic force microscopy, phase analysis light scattering and laser diffraction are the methods used for characterization of HA-coated particles. The zeta potential and thickness of HA-layer of HA-coated Dynabeads M270 Amine were -50 mV and 85 nm, respectively, and of HA-coated p(GMA-MOEAA)-NH2 were -38 mV and 140 nm, respectively. The electrochemical analysis confirmed the zero leakage of magnetic material and no reactivity of particles with hydrogen peroxide. The rate of non-specific sorption of bovine serum albumin was reduced up to 50% of naked ones. The coating efficiency and suitability of biopolymer-based microparticles for magnetically active microfluidic devices was confirmed. Highlights: Post-synthetic surface modification of magnetic microparticles by hyaluronic acid  Hyaluronic acid -polymer of unique physicochemical and biological characteristics ABSTRACTIron oxide based particles functionalized by bioactive molecules have been utilized extensively in biotechnology and biomedicine. Despite their already proven advantages, instability under changing reaction conditions, non-specific sorption of biomolecules on the particles' surfaces, and iron oxide leakage from the naked particles can greatly limit their application. As confirmed many times, surface treatment with an appropriate stabilizer helps to minimize these disadvantages.In this work, we describe enhanced post-synthetic surface modification of superparamagnetic microparticles varying in materials and size using hyaluronic acid (HA) in various chain lengths. Scanning electron microscopy, atomic force microscopy, phase analysis light scattering and laser diffraction are the methods used for characterization of HA-coated particles. The zeta potential and thickness of HA-layer of HA-coated Dynabeads M270Amine were -50 mV and 85 nm, respectively, and of HA-coated p(GMA-MOEAA)-NH 2 were -38 mV and 140 nm, respectively. The electrochemical analysis confirmed the zero leakage of magnetic material and no reactivity of particles with hydrogen peroxide. The rate of nonspecific sorption of bovine serum albumin was reduced up to 50% of naked ones. The coating efficiency and suitability of biopolymer-based microparticles for magnetically active microfluidic devices was confirmed.

show abstract

Coating Nanomagnetic Particles for Biomedical Applications

Cited by 18 publications

References 104 publications

Magnetic Hyperthermia using Cobalt Ferrite Nanoparticles: The Influence of Particle Size

Magnetic Hyperthermia using Cobalt Ferrite Nanoparticles: The Influence of Particle Size

A solvent-free synthesis of polyhydroquinolines via Hantzsch multicomponent condensation catalyzed by nanomagnetic-supported sulfonic acid

Magnetic microparticles post-synthetically coated by hyaluronic acid as an enhanced carrier for microfluidic bioanalysis

Contact Info

Product

Resources

About